A
Ayca Kiykim
Researcher at Istanbul University
Publications - 102
Citations - 1631
Ayca Kiykim is an academic researcher from Istanbul University. The author has contributed to research in topics: Medicine & Immunodeficiency. The author has an hindex of 14, co-authored 75 publications receiving 916 citations. Previous affiliations of Ayca Kiykim include Medical University of Vienna & Marmara University.
Papers
More filters
Journal ArticleDOI
Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study
Federica Barzaghi,Laura C. Amaya Hernandez,Benedicte Neven,Silvia Ricci,Zeynep Yesim Kucuk,Jack J. Bleesing,Zohreh Nademi,Mary Slatter,Erlinda R. Ulloa,Anna Shcherbina,Anna Roppelt,Austen Worth,Juliana Silva,Alessandro Aiuti,Luis Murguia-Favela,Carsten Speckmann,Magda Carneiro-Sampaio,Juliana Folloni Fernandes,Safa Baris,Ahmet Ozen,Elif Karakoc-Aydiner,Ayca Kiykim,Ansgar Schulz,Sandra Steinmann,Lucia Dora Notarangelo,Eleonora Gambineri,Paolo Lionetti,William T. Shearer,Lisa R. Forbes,Caridad Martinez,Despina Moshous,Stéphane Blanche,Alain Fisher,Frank M. Ruemmele,Come Tissandier,Marie Ouachée-Chardin,Frédéric Rieux-Laucat,Marina Cavazzana,Waseem Qasim,Barbarella Lucarelli,Michael H. Albert,Ichiro Kobayashi,Laura C. Alonso,Cristina Díaz de Heredia,Hirokazu Kanegane,Anita Lawitschka,Jong Jin Seo,Marta González-Vicent,Miguel Angel Diaz,Rakesh K. Goyal,Martin Sauer,Akif Yesilipek,Minsoo Kim,Yesim Yilmaz-Demirdag,Monica Bhatia,Julie Khlevner,Erick J. Richmond Padilla,Silvana Martino,Davide Montin,Olaf Neth,Agueda Molinos-Quintana,Justo Valverde-Fernandez,Arnon Broides,Vered Pinsk,Antje Ballauf,Filomeen Haerynck,Victoria Bordon,Catharina Dhooge,Maria Laura Garcia-Lloret,Robbert G. M. Bredius,Krzysztof Kałwak,Elie Haddad,Markus G. Seidel,Gregor Dückers,Sung-Yun Pai,Sung-Yun Pai,Christopher C. Dvorak,Stephan Ehl,Franco Locatelli,Frederick D. Goldman,Andrew R. Gennery,M.J. Cowan,Maria Grazia Roncarolo,Rosa Bacchetta +83 more
TL;DR: Patients receiving chronic IS were hampered by disease recurrence or complications, impacting long‐term disease‐free survival, and when performed in patients with a low OI score, HSCT resulted in disease resolution with better quality of life, independent of age, donor source, or conditioning regimen.
Journal ArticleDOI
Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry
Maria Elena Maccari,Hassan Abolhassani,Hassan Abolhassani,Asghar Aghamohammadi,Alessandro Aiuti,Olga Aleinikova,C. Bangs,Safa Baris,Federica Barzaghi,Helen Baxendale,Matthew Buckland,Siobhan O. Burns,Caterina Cancrini,Caterina Cancrini,Andrew J. Cant,Pascal Cathébras,Marina Cavazzana,Marina Cavazzana,Marina Cavazzana,Anita Chandra,Francesca Conti,Francesca Conti,Tanya I. Coulter,Lisa Devlin,J. David M. Edgar,Saul N. Faust,Alain Fischer,Alain Fischer,Alain Fischer,Marina Garcia Prat,Lennart Hammarström,Maximilian Heeg,Stephen Jolles,Elif Karakoc-Aydiner,Gerhard Kindle,Ayca Kiykim,Dinakantha S. Kumararatne,Bodo Grimbacher,Hilary Longhurst,Nizar Mahlaoui,Nizar Mahlaoui,Tomas Milota,Fernando Moreira,Despina Moshous,Despina Moshous,Despina Moshous,Anna Mukhina,Olaf Neth,Benedicte Neven,Benedicte Neven,Benedicte Neven,Alexandra Nieters,Peter Olbrich,Ahmet Ozen,Jana Pachlopnik Schmid,Capucine Picard,Capucine Picard,Seraina Prader,William Rae,Janine Reichenbach,Stephan Rusch,Sinisa Savic,Alessia Scarselli,Alessia Scarselli,Raphael Scheible,Anna Sediva,Svetlana O. Sharapova,Anna Shcherbina,Mary Slatter,Pere Soler-Palacín,Aurélie Stanislas,Felipe Suarez,Francesca Tucci,Annette Uhlmann,Joris M. van Montfrans,Klaus Warnatz,Anthony P. Williams,Phil Wood,Sven Kracker,Sven Kracker,Alison M. Condliffe,Stephan Ehl +81 more
TL;DR: The European Society for Immunodeficiencies (ESID)-APDS registry as discussed by the authors provides a comprehensive baseline documentation for a growing cohort that will be followed prospectively to establish prognostic factors and identify patients for treatment studies.
Journal ArticleDOI
CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis
Ahmet Ozen,William A. Comrie,Rico Chandra Ardy,Cecilia Domínguez Conde,Buket Dalgic,Ömer Faruk Beşer,Aaron Morawski,Elif Karakoc-Aydiner,Engin Tutar,Safa Baris,Figen Özçay,Nina K. Serwas,Yu Zhang,Helen F. Matthews,Stefania Pittaluga,Les R. Folio,Aysel Ünlüsoy Aksu,Joshua McElwee,Ana Krolo,Ayca Kiykim,Zeren Baris,Meltem Gulsan,Ismail Ogulur,Scott B. Snapper,Roderick H. J. Houwen,Helen L. Leavis,Deniz Ertem,Renate Kain,Sinan Sari,Tülay Erkan,Helen C. Su,Kaan Boztug,Michael J. Lenardo +32 more
TL;DR: CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein‐losing enteropathy (the CHAPLE syndrome) is caused by abnormal complement activation due to biallelic loss‐of‐function mutations in CD55.
Journal ArticleDOI
Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency.
Ayca Kiykim,Ismail Ogulur,Esra Dursun,Louis-Marie Charbonnier,Ercan Nain,Şükrü Çekiç,Dilek Dogruel,Neslihan Edeer Karaca,Mujde Tuba Cogurlu,Ozlem Arman Bilir,Murat Cansever,Hasan Kapakli,Dilek Baser,Nurhan Kasap,Şeyhan Kutluğ,Derya Ufuk Altintas,Ahmad Al-Shaibi,Nourhen Agrebi,Manolya Kara,Ayla Güven,Ayper Somer,Cigdem Aydogmus,Nuray Aktay Ayaz,Ayse Metin,Metin Aydogan,Aysen Uncuoglu,Turkan Patiroglu,Alisan Yildiran,Şükrü Nail Güner,Sevgi Keles,Ismail Reisli,Guzide Aksu,Necil Kutukculer,Sara Sebnem Kilic,Mustafa Yilmaz,Elif Karakoc-Aydiner,Bernice Lo,Ahmet Ozen,Talal A. Chatila,Safa Baris +39 more
TL;DR: Long-term Abatacept therapy is effective in the majority of patients with LRBA deficiency, and high cTFH cell frequencies persisted in two patients who had a more severe disease phenotype that was relatively resistant to abatACEpt therapy.
Journal ArticleDOI
Vitamin D as an adjunct to subcutaneous allergen immunotherapy in asthmatic children sensitized to house dust mite.
TL;DR: This work aimed to investigate the efficacy, safety, and T regulatory cell response of vitamin D as an adjunct to allergen‐specific immunotherapy (IT) in mice.