C
C.T. Chou
Researcher at Taipei Veterans General Hospital
Publications - 10
Citations - 4104
C.T. Chou is an academic researcher from Taipei Veterans General Hospital. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 5, co-authored 5 publications receiving 3381 citations. Previous affiliations of C.T. Chou include National Yang-Ming University.
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Journal ArticleDOI
The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection
Martin Rudwaleit,D. van der Heijde,Robert Landewé,Joachim Listing,Nurullah Akkoc,J Brandt,Jürgen Braun,C.T. Chou,Eduardo Collantes-Estevez,Maxime Dougados,Feng Huang,Jieruo Gu,Muhammad Asim Khan,Yesim Kirazli,Walter P. Maksymowych,Herman Mielants,Inge Juul Sørensen,Salih Ozgocmen,Euthalia Roussou,R. Valle-Oñate,Ulrich Weber,James Cheng-Chung Wei,Joachim Sieper +22 more
TL;DR: The new ASAS classification criteria for axial SpA can reliably classify patients for clinical studies and may help rheumatologists in clinical practice in diagnosing axial spondyloarthritis in those with chronic back pain.
Journal ArticleDOI
The Assessment of SpondyloArthritis international Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general
Martin Rudwaleit,D. van der Heijde,Robert Landewé,Nurullah Akkoc,J Brandt,C.T. Chou,Maxime Dougados,Feng Huang,Jieruo Gu,Yesim Kirazli,F. Van den Bosch,Ivana Olivieri,Euthalia Roussou,Salvatore Scarpato,Inge Juul Sørensen,R. Valle-Oñate,Ulrich Weber,James Cheng-Chung Wei,J. Sieper +18 more
TL;DR: The new ASAS classification criteria for peripheral SpA performed well in patients presenting with peripheral arthritis, enthesitis and/or dactylitis, particularly regarding sensitivity.
Journal ArticleDOI
ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients
Philip Robinson,Mary-Ellen Costello,Paul Leo,Linda A. Bradbury,Kelly A. Hollis,Adrian Cortes,Seung-Hun Lee,Kyung Bin Joo,Seung Cheol Shim,Michael H. Weisman,Michael Ward,Xiaodong Zhou,Henri Jean Garchon,Gilles Chiocchia,Johannes C. Nossent,Johannes C. Nossent,Benedicte A. Lie,Øystein Førre,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Kari Laiho,Lei Jiang,Yu Liu,Xin Wu,Dirk Elewaut,Ruben Burgos-Vargas,Lianne S. Gensler,Simon Stebbings,Nigil Haroon,Juan Mulero,José Luis Fernández-Sueiro,Miguel A. Gonzalez-Gay,Carlos López-Larrea,Paul Bowness,Karl Gafney,J. S. H. Gaston,Dafna D. Gladman,Dafna D. Gladman,Proton Rahman,Walter P. Maksymowych,Huji Xu,Irene E. van der Horst-Bruinsma,C.T. Chou,C.T. Chou,Raphael Valle-Oñate,Maria Consuelo Romero-Sanchez,Inger Myrnes Hansen,Fernando Pimentel-Santos,Robert D. Inman,Javier Martin,Maxime Breban,David M. Evans,David M. Evans,John D. Reveille,Tae-Hwan Kim,B. Paul Wordsworth,Matthew A. Brown +57 more
Abstract: The association of endoplasmic reticulum aminopeptidase 2 (ERAP2) with ankylosing spondylitis (AS) was recently described in the large International Genetics of AS Consortium Immunochip study. Variants in ERAP2 have also been associated with inflammatory bowel disease, psoriasis, acute anterior uveitis and birdshot chorioretinopathy. Subsequent investigation demonstrated an association of ERAP2 with AS which was present when one conditioned on one of the two independent haplotypes of ERAP1 associated with AS or when HLA-B27-negative patients were analysed separately. These two analyses provide analogous evidence for the association of ERAP2 with AS in HLA-B27-negative cases because of the genetic interaction between HLA-B27 and the AS-associated ERAP1 variants in AS cases. ERAP1 and ERAP2 are located on chromosome 5q15 in the opposite orientation. The locus is challenging to analyse because of the strong linkage disequilibrium (LD) across the locus and the epistasis between ERAP1 and HLA-B alleles associated with AS. We therefore sought to investigate the association of ERAP2 with AS in HLA-B27-positive patients. This is of clinical importance because functional studies have demonstrated that the strongly AS-protective variant rs2248374 causes a functional ERAP2 protein knockout, because its G allele causes a loss of ERAP2 protein expression. There is also a variant of ERAP2 which changes its enzyme catalytic activity and specificity (rs2549782, K392A). Because this is in almost complete LD with rs2248374 (1000 Genomes D′=1.00, r2=0.90), it is almost never translated in vivo. Further, the very strong LD between these markers means that analysis of rs2549782 for association would yield results almost identical to the results for rs2248374 presented below. Therefore, it is of relevance to determine whether the association of ERAP2 with HLA-B27-negative disease is also found in HLA-B27-positive cases, since ERAP inhibition may offer a novel therapeutic for AS...
Journal Article
Genetic diagnostic profiling in axial spondyloarthritis: a real world study
Gethin P. Thomas,Dana Willner,Philip Robinson,Adrian Cortes,Ran Duan,Martin Rudwaleit,Nurullah Akkoc,Jürgen Braun,C.T. Chou,Walter P. Maksymowych,Salih Ozgocmen,Euthalia Roussou,Joachim Sieper,Rafael Valle-Oñate,Désirée van der Heijde,James Cheng-Chung Wei,Paul Leo,Matthew A. Brown +17 more
TL;DR: In a clinical setting of referred back pain patients suspected to have axial SpA, genetic data was unable to use genetic data to construct a predictive model better than that based on existing clinical data.
Genetic diagnostic profiling in axial spondyloarthritis: a real world study
Gethin P. Thomas,Dana Willner,Philip Robinson,Adrian Cortes,Ran Duan,M. Rudwaleit,Nurullah Akkoc,J. Braun,C.T. Chou,Walter P. Maksymowych,Salih Ozgocmen,Euthalia Roussou,Joachim Sieper,R. Valle-Oñate,D. van der Heijde,James Cheng-Chung Wei,Paul Leo,Brown +17 more
TL;DR: In this paper, the ability of genetic profiling to diagnose axial SpA ( axSpA ) as a whole group, or ankylosing spondylitis ( AS ) alone, in a cohort of chronic back pain patients was tested.