C
Carol Kan
Researcher at King's College London
Publications - 49
Citations - 1573
Carol Kan is an academic researcher from King's College London. The author has contributed to research in topics: Eating disorders & Anorexia nervosa (differential diagnoses). The author has an hindex of 16, co-authored 46 publications receiving 1027 citations. Previous affiliations of Carol Kan include National Health Service & South London and Maudsley NHS Foundation Trust.
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Journal ArticleDOI
A Systematic Review and Meta-analysis of the Association Between Depression and Insulin Resistance
Carol Kan,Naomi Silva,Sherita Hill Golden,Ulla Rajala,Markuu J. Timonen,Daniel Stahl,Khalida Ismail +6 more
TL;DR: A small but significant cross-sectional association was observed between depression and IR, despite heterogeneity between studies, and the pathophysiology mechanisms and direction of this association need further study.
Journal ArticleDOI
A major role for common genetic variation in anxiety disorders
Kirstin L. Purves,Jonathan R. I. Coleman,Sandra Meier,Sandra Meier,Sandra Meier,Christopher Rayner,Katrina A. S. Davis,Rosa Cheesman,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Anders D. Børglum,Anders D. Børglum,Shing Wan Cho,Jürgen Deckert,Helena Gaspar,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,John M. Hettema,Matthew Hotopf,David M. Hougaard,David M. Hougaard,Christopher Hübel,Christopher Hübel,Carol Kan,Andrew M. McIntosh,Ole Mors,Ole Mors,Preben Bo Mortensen,Preben Bo Mortensen,Merete Nordentoft,Merete Nordentoft,Thomas Werge,Thomas Werge,Thomas Werge,Kristin K. Nicodemus,Manuel Mattheisen,Gerome Breen,Thalia C. Eley +37 more
TL;DR: It is concluded that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.
Journal ArticleDOI
Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations.
Yuri Milaneschi,Femke Lamers,Wouter J. Peyrot,Bernhard T. Baune,Gerome Breen,Gerome Breen,Abbas Dehghan,Andreas J. Forstner,Hans J. Grabe,Georg Homuth,Carol Kan,Carol Kan,Cathryn M. Lewis,Niamh Mullins,Matthias Nauck,Giorgio Pistis,Martin Preisig,Margarita Rivera,Margarita Rivera,Marcella Rietschel,Fabian Streit,Jana Strohmaier,Alexander Teumer,Sandra Van der Auwera,Naomi R. Wray,Dorret I. Boomsma,Brenda W.J.H. Penninx +26 more
TL;DR: Genetic associations between atypical depressive symptoms and obesity-related traits may arise from shared pathophysiologic mechanisms in patients with MDD and development of treatments effectively targeting immunometabolic dysregulations may benefit patients with depression and obesity, both syndromes with important disability.
Journal ArticleDOI
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Coleman Jri,Wouter J. Peyrot,Kirstin L. Purves,Davis Kas.,Christopher Rayner,Shing Wan Choi,Christopher Hübel,Helena Gaspar,Carol Kan,Van der Auwera S,Mark Adams,Donald M. Lyall,Karmel W. Choi,Erin C. Dunn,Evangelos Vassos,Andrea Danese,Barbara Maughan,Hans J. Grabe,Cathryn M. Lewis,Paul F. O'Reilly,Andrew M. McIntosh,Daniel J. Smith,Naomi R. Wray,Matthew Hotopf,Thalia C. Eley,Gerome Breen +25 more
TL;DR: The results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.
Journal ArticleDOI
Pharmacogenetics of antidepressant response: a polygenic approach
Judit García-González,Katherine E. Tansey,Joanna Hauser,Neven Henigsberg,Wolfgang Maier,Ole Mors,Anna Placentino,Marcella Rietschel,Daniel Souery,Tina Žagar,Piotr M. Czerski,Borut Jerman,Henriette N. Buttenschøn,Thomas G. Schulze,Astrid Zobel,Anne Farmer,Katherine J. Aitchison,Ian W. Craig,Peter McGuffin,Michel Giupponi,Nader Perroud,Guido Bondolfi,David M. Evans,Michael Conlon O'Donovan,Tim J Peters,Jens R. Wendland,Glyn Lewis,Shitij Kapur,Roy H. Perlis,Volker Arolt,Katharina Domschke,Gerome Breen,Charles Curtis,Lee Sang-Hyuk,Carol Kan,Stephen Newhouse,Hamel Patel,Bernhard T. Baune,Rudolf Uher,Cathryn M. Lewis,Chiara Fabbri +40 more
TL;DR: The genetic liability to MDD or schizophrenia did not predict response to antidepressants, suggesting differences between the genetic component of depression and treatment response, and larger or more homogeneous studies will be necessary to obtain a polygenic predictor of antidepressant response.