A major role for common genetic variation in anxiety disorders
Kirstin L. Purves,Jonathan R. I. Coleman,Sandra Meier,Sandra Meier,Sandra Meier,Christopher Rayner,Katrina A. S. Davis,Rosa Cheesman,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Anders D. Børglum,Anders D. Børglum,Shing Wan Cho,Jürgen Deckert,Helena Gaspar,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,John M. Hettema,Matthew Hotopf,David M. Hougaard,David M. Hougaard,Christopher Hübel,Christopher Hübel,Carol Kan,Andrew M. McIntosh,Ole Mors,Ole Mors,Preben Bo Mortensen,Preben Bo Mortensen,Merete Nordentoft,Merete Nordentoft,Thomas Werge,Thomas Werge,Thomas Werge,Kristin K. Nicodemus,Manuel Mattheisen,Gerome Breen,Thalia C. Eley +37 more
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TLDR
It is concluded that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.Abstract:
Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30–60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.read more
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Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
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McGrath,Martin McKee,Claire McNellan,Suresh Mehata,Man Mohan Mehndiratta,Tefera Chane Mekonnen,Peter Memiah,Ziad A. Memish,Walter Mendoza,Mubarek Abera Mengistie,Desalegn Tadese Mengistu,George A. Mensah,Tuomo J. Meretoja,Atte Meretoja,Haftay Berhane Mezgebe,Renata Micha,Anoushka Millear,Ted R. Miller,Ted R. Miller,Edward J Mills,Mojde Mirarefin,Erkin M. Mirrakhimov,Awoke Misganaw,Shiva Raj Mishra,Philip B. Mitchell,Karzan Abdulmuhsin Mohammad,Alireza Mohammadi,Kedir Endris Mohammed,Shafiu Mohammed,Sanjay K. Mohanty,Ali H. Mokdad,Sarah K Mollenkopf,Lorenzo Monasta,Marcella Montico,Maziar Moradi-Lakeh,Paula Moraga,Rintaro Mori,Chloe Morozoff,Shane D. Morrison,Mark Moses,Cliff Mountjoy-Venning,Kalayu Birhane Mruts,Ulrich O Mueller,Kate Muller,M. E. Murdoch,Gudlavalleti V S Murthy,Kamarul Imran Musa,Jean B. Nachega,Gabriele Nagel,Mohsen Naghavi,Aliya Naheed,Kovin Naidoo,Luigi Naldi,Vinay Nangia,Gopalakrishnan Natarajan,Dumessa Edessa Negasa,Ruxandra Irina Negoi,Ionut Negoi,Charles R. Newton,Charles R. Newton,Josephine W. Ngunjiri,Trang Huyen Nguyen,Quyen Nguyen,Cuong Tat Nguyen,Grant Nguyen,Minh Nguyen,Emma Nichols,Dina Nur Anggraini Ningrum,Dina Nur Anggraini Ningrum,Sandra Nolte,Vuong Minh Nong,Bo Norrving,Jean Jacques Noubiap,Martin O'Donnell,Felix Akpojene Ogbo,In-Hwan Oh,Anselm Okoro,Olanrewaju Oladimeji,Olanrewaju Oladimeji,Tinuke O Olagunju,Andrew T Olagunju,Andrew T Olagunju,Helen E Olsen,Bolajoko O. Olusanya,Jacob Olusegun Olusanya,Kanyin Ong,John Nelson Opio,Eyal Oren,Eyal Oren,Alberto Ortiz,Aaron Osgood-Zimmerman,Majdi Osman,Mayowa O. Owolabi,Mahesh Pa,Rosana E. Pacella,Adrian Pana,Basant Kumar Panda,Christina Papachristou,Christina Papachristou,Eun-Kee Park,Charles D. H. Parry,Mahboubeh Parsaeian,Scott B. Patten,George C Patton,Katherine R. Paulson,Neil Pearce,David M. Pereira,David M. Pereira,Norberto Perico,Konrad Pesudovs,Carrie Beth Peterson,Max Petzold,Michael R. Phillips,David M. Pigott,Julian David Pillay,Christine Pinho,Dietrich Plass,Martin A Pletcher,Svetlana Popova,Richie Poulton,Farshad Pourmalek,Dorairaj Prabhakaran,Noela M Prasad,Narayan Prasad,Carrie Purcell,Mostafa Qorbani,Reginald Quansah,Beatriz Paulina Ayala Quintanilla,Rynaz H S Rabiee,Amir Radfar,Anwar Rafay,Kazem Rahimi,Afarin Rahimi-Movaghar,Vafa Rahimi-Movaghar,Mohammad Hifz Ur Rahman,Mahfuzar Rahman,Rajesh Kumar Rai,Sasa Rajsic,Usha Ram,Chhabi Lal Ranabhat,Zane Rankin,Puja C Rao,P. V. Rao,Salman Rawaf,Sarah E Ray,Robert C. Reiner,Nikolas Reinig,Marissa B Reitsma,Giuseppe Remuzzi,Andre M. N. Renzaho,Serge Resnikoff,Satar Rezaei,Antonio Luiz Pinho Ribeiro,Luca Ronfani,Gholamreza Roshandel,Gholamreza Roshandel,Gregory A. Roth,Ambuj Roy,Enrico Rubagotti,George Mugambage Ruhago,Soheil Saadat,Nafis Sadat,Mahdi Safdarian,Sare Safi,Saeid Safiri,Rajesh Sagar,Ramesh Sahathevan,Joseph Salama,Huda Omer Ba Saleem,Joshua A. Salomon,Sundeep Salvi,Abdallah M. Samy,Juan Sanabria,Juan Sanabria,Damian Santomauro,Itamar S. Santos,João Vasco Santos,Milena M Santric Milicevic,Benn Sartorius,Maheswar Satpathy,Monika Sawhney,Sonia Saxena,Maria Inês Schmidt,Ione Jayce Ceola Schneider,Ben Schöttker,David C. Schwebel,Falk Schwendicke,Soraya Seedat,Sadaf G. Sepanlou,Sadaf G. Sepanlou,Edson Serván-Mori,Tesfaye Setegn,Katya Anne Shackelford,Amira Shaheen,Masood Ali Shaikh,Mansour Shamsipour,Sheikh Mohammed Shariful Islam,Sheikh Mohammed Shariful Islam,Jayendra Sharma,Rajesh Sharma,Jun She,Peilin Shi,Chloe Shields,Girma Temam Shifa,Mika Shigematsu,Yukito Shinohara,Rahman Shiri,Reza Shirkoohi,Shreya Shirude,Kawkab Shishani,Mark G. Shrime,Abla M. Sibai,Inga Dora Sigfusdottir,Inga Dora Sigfusdottir,Diego Augusto Santos Silva,João Pedro Silva,Dayane Gabriele Alves Silveira,Jasvinder A. Singh,Narinder Pal Singh,Dhirendra N Sinha,Eirini Skiadaresi,Vegard Skirbekk,Erica Leigh Slepak,Amber Sligar,David L. Smith,Mari Smith,Badr Hasan Sobaih,Eugene Sobngwi,Reed J D Sorensen,Tatiane Cristina Moraes Sousa,Luciano A. Sposato,Chandrashekhar T Sreeramareddy,Vinay Srinivasan,Jeffrey D. Stanaway,Vasiliki Stathopoulou,Nicholas Steel,Murray B. Stein,Dan J. Stein,Dan J. Stein,Timothy J. Steiner,Timothy J. Steiner,Caitlyn Steiner,S. Steinke,S. Steinke,Mark A. Stokes,Lars Jacob Stovner,Bryan Strub,Michelle L Subart,Mu'awiyyah Babale Sufiyan,Bruno F. Sunguya,Bruno F. Sunguya,Patrick J Sur,Patrick J Sur,Soumya Swaminathan,Bryan L. Sykes,Dillon O Sylte,Rafael Tabarés-Seisdedos,Getachew Redae Taffere,Jukka Takala,Nikhil Tandon,Mohammad Tavakkoli,Nuno Taveira,Hugh R. Taylor,Arash Tehrani-Banihashemi,Tesfalidet Tekelab,Abdullah Sulieman Terkawi,Dawit Jember Tesfaye,Belay Tesssema,Ornwipa Thamsuwan,Katie E Thomas,Amanda G. 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TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016.
Journal Article
A Brief Measure for Assessing Generalized Anxiety Disorder: The GAD-7
TL;DR: The GAD-7 is a valid and efficient tool for screening for GAD and assessing its severity in clinical practice and research.
Journal ArticleDOI
Global, regional, and national incidence, prevalence, andyears lived with disability for 354 diseases and injuries for195 countries and territories, 1990–2017: a systematicanalysis for the Global Burden of Disease Study 2017
Gbd Disease,Injury Incidence,Lorenzo Monasta,Luca Ronfani,Ettore Beghi,Giorgia Giussani,Boris Bikbov,Norberto Perico,Cristina Bosetti,Monica Cortinovis,Silvano Gallus,Giuseppe Remuzzi +11 more
TL;DR: All-cause age-standardised YLD rates decreased by 3·9% from 1990 to 2017; however, the all-age YLD rate increased by 7·2% while the total sum of global YLDs increased from 562 million (421–723) to 853 million (642–1100).
Journal ArticleDOI
Second-generation PLINK: rising to the challenge of larger and richer datasets
Christopher C. Chang,Carson C. Chow,Laurent C. A. M. Tellier,Shashaank Vattikuti,Shaun Purcell,James J. Lee +5 more
TL;DR: The second-generation versions of PLINK will offer dramatic improvements in performance and compatibility, and for the first time, users without access to high-end computing resources can perform several essential analyses of the feature-rich and very large genetic datasets coming into use.
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