C
Christopher Smillie
Researcher at Broad Institute
Publications - 50
Citations - 24796
Christopher Smillie is an academic researcher from Broad Institute. The author has contributed to research in topics: Immune system & Cell type. The author has an hindex of 25, co-authored 47 publications receiving 20233 citations. Previous affiliations of Christopher Smillie include Pasteur Institute & Massachusetts Institute of Technology.
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Journal ArticleDOI
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Christoph Muus,Malte D Luecken,Gökcen Eraslan,Lisa Sikkema,Avinash Waghray,Graham Heimberg,Yoshihiko Kobayashi,Eeshit Dhaval Vaishnav,Eeshit Dhaval Vaishnav,Ayshwarya Subramanian,Christopher Smillie,Karthik A. Jagadeesh,Elizabeth Thu Duong,Evgenij Fiskin,Elena Torlai Triglia,Meshal Ansari,Peiwen Cai,Brian M. Lin,Justin Buchanan,Sijia Chen,Jian Shu,Adam L. Haber,Adam L. Haber,Hattie Chung,Daniel T. Montoro,Taylor Adams,Hananeh Aliee,Samuel J. Allon,Samuel J. Allon,Samuel J. Allon,Zaneta Andrusivova,Ilias Angelidis,Orr Ashenberg,Kevin Bassler,Christophe Bécavin,Inbal Benhar,Joseph Bergenstråhle,Ludvig Bergenstråhle,Liam Bolt,Emelie Braun,Linh T. Bui,Steven Callori,Mark Chaffin,Evgeny Chichelnitskiy,Joshua Chiou,Thomas M. Conlon,Michael S. Cuoco,Anna S E Cuomo,Marie Deprez,Grant Duclos,Denise Fine,David S. Fischer,Shila Ghazanfar,Astrid Gillich +53 more
TL;DR: In this paper, cell-type-specific expression of ACE2, TMPRSS2 and CTSL across 107 single-cell RNA-sequencing studies from different tissues was assessed.
Journal ArticleDOI
Short-Term Signatures of Evolutionary Change in the Salmonella enterica Serovar Typhimurium 14028 Genome
TL;DR: Comparison of the complete genomic sequence of the S. Typhimurium genomes revealed differences in the patterns of sequence evolution and the complete inventory of genetic alterations incurred in virulent and avirulent strains, as well as the sequence changes accumulated during laboratory passage of pathogenic organisms.
Journal ArticleDOI
Natural Bacterial Communities Serve as Quantitative Geochemical Biosensors
Mark Smith,Andrea M. Rocha,Christopher Smillie,Scott W. Olesen,Charles J. Paradis,Liyou Wu,James H. Campbell,James H. Campbell,Julian L. Fortney,Tonia L. Mehlhorn,Kenneth A. Lowe,Jennifer Earles,Jana R. Phillips,Steve M. Techtmann,Dominique C. Joyner,Dwayne A. Elias,Kathryn L. Bailey,Richard A. Hurt,Sarah P. Preheim,Matthew C. Sanders,Joy Y. Yang,Marcella A. Mueller,Scott C. Brooks,David B. Watson,Ping Zhang,Zhili He,Eric A. Dubinsky,Paul D. Adams,Paul D. Adams,Adam P. Arkin,Adam P. Arkin,Matthew W. Fields,Jizhong Zhou,Eric J. Alm,Terry C. Hazen +34 more
TL;DR: It is shown that statistical analysis of DNA from natural microbial communities can be used to accurately identify environmental contaminants, including uranium and nitrate at a nuclear waste site, and the bacterial strains that are most useful for detecting oil and uranium are known to interact with these substrates.
Posted ContentDOI
A single-cell and single-nucleus RNA-seq toolbox for fresh and frozen human tumors
Michal Slyper,Caroline B. M. Porter,Orr Ashenberg,Julia Waldman,Eugene Drokhlyansky,Isaac Wakiro,Isaac Wakiro,Christopher Smillie,Gabriela Smith-Rosario,Jingyi Wu,Jingyi Wu,Danielle Dionne,Sébastien Vigneau,Sébastien Vigneau,Judit Jané-Valbuena,Sara Napolitano,Sara Napolitano,Mei-Ju Su,Mei-Ju Su,Anand G. Patel,Asa Karlstrom,Simon Gritsch,Masashi Nomura,Avinash Waghray,Satyen H. Gohil,Satyen H. Gohil,Alexander M. Tsankov,Livnat Jerby-Arnon,Ofir Cohen,Ofir Cohen,Johanna Klughammer,Yanay Rosen,Joshua Gould,Bo Li,Bo Li,Lan Nguyen,Catherine J. Wu,Benjamin Izar,Rizwan Haq,Rizwan Haq,F. Stephen Hodi,Charles H. Yoon,Charles H. Yoon,Aaron N. Hata,Suzanne J. Baker,Mario L. Suvà,Mario L. Suvà,Raphael Bueno,Elizabeth H. Stover,Elizabeth H. Stover,Ursula A. Matulonis,Ursula A. Matulonis,Michael R. Clay,Michael A. Dyer,Michael A. Dyer,Natalie B. Collins,Natalie B. Collins,Natalie B. Collins,Nikhil Wagle,Nikhil Wagle,Asaf Rotem,Asaf Rotem,Bruce E. Johnson,Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,Aviv Regev +66 more
TL;DR: This work provides direct guidance across a broad range of tumors, including criteria for testing and selecting methods from the toolbox for other tumors, thus paving the way for charting tumor atlases.
Journal Article
Unraveling the processes shaping mammalian gut microbiomes over evolutionary time
Mathieu Groussin,Florent Mazel,Jon G. Sanders,Christopher Smillie,Christopher Smillie,Sébastien Lavergne,Wilfried Thuiller,Eric J. Alm,Eric J. Alm +8 more
TL;DR: It is shown that host phylogeny and major dietary shifts have affected the distribution of different gut bacterial lineages and did so on vastly different bacterial phylogenetic resolutions, supporting co-speciation as having a significant role in the evolution of mammalian gut microbiome compositions.