C
Clive N. Svendsen
Researcher at Cedars-Sinai Medical Center
Publications - 298
Citations - 24189
Clive N. Svendsen is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 78, co-authored 283 publications receiving 21604 citations. Previous affiliations of Clive N. Svendsen include University of Wisconsin-Madison & University of California, Los Angeles.
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Journal ArticleDOI
Induced pluripotent stem cells from a spinal muscular atrophy patient
Allison D. Ebert,Junying Yu,Ferrill F. Rose,Virginia B. Mattis,Christian L. Lorson,James A. Thomson,Clive N. Svendsen +6 more
TL;DR: This is the first study to show that human induced pluripotent stem cells can be used to model the specific pathology seen in a genetically inherited disease and represents a promising resource to study disease mechanisms, screen new drug compounds and develop new therapies.
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Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease
Steven S. Gill,Nikunj K. Patel,Gary Hotton,Karen O’Sullivan,Renée McCarter,Martin Bunnage,David J. Brooks,Clive N. Svendsen,Peter Heywood +8 more
TL;DR: Positron emission tomography scans of [18F]dopamine uptake showed a significant 28% increase in putamen dopamine storage after 18 months, suggesting a direct effect of GDNF on dopamine function, and warrants careful examination ofGDNF as a treatment for Parkinson disease.
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Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice
Toby G Bush,Narman Puvanachandra,Catherine H. Horner,Anabella Polito,Thor Ostenfeld,Clive N. Svendsen,Lennart Mucke,Martin H. Johnson,Michael V. Sofroniew +8 more
TL;DR: These findings show that genetic targeting can be used to ablate scar-forming astrocytes and demonstrate roles for astroCytes in regulating leukocyte trafficking, repairing the BBB, protecting neurons, and restricting nerve fiber growth after injury in the adult central nervous system.
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Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
Dhruv Sareen,Jacqueline G. O’Rourke,Pratap Meera,A. K. M. G. Muhammad,Sharday Grant,Megan Simpkinson,Shaughn Bell,Sharon Carmona,Loren Ornelas,Anais Sahabian,Tania F. Gendron,Leonard Petrucelli,Michael Baughn,John Ravits,Matthew B. Harms,Frank Rigo,C. Frank Bennett,Thomas S. Otis,Clive N. Svendsen,Robert H. Baloh +19 more
TL;DR: Findings support the idea that the buildup of “toxic” RNA containing the GGGGCC repeat contributes to the death of motor neurons in ALS, and suggest that antisense oligonucleotides targeting this transcript may be a strategy for treating ALS patients with the C9ORF72 repeat expansion.
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A new method for the rapid and long term growth of human neural precursor cells
Clive N. Svendsen,M. G. ter Borg,Richard J. E. Armstrong,Anne Elizabeth Rosser,Siddharthan Chandran,Thor Ostenfeld,Maeve A. Caldwell +6 more
TL;DR: This simple and novel culture method allows the rapid expansion of large numbers of non-transformed human neural precursor cells which may be of use in drug discovery, ex vivo gene therapy and clinical neural transplantation.