D
Daniel P. Howrigan
Researcher at Harvard University
Publications - 65
Citations - 19452
Daniel P. Howrigan is an academic researcher from Harvard University. The author has contributed to research in topics: Exome & Genome-wide association study. The author has an hindex of 28, co-authored 57 publications receiving 14603 citations. Previous affiliations of Daniel P. Howrigan include Broad Institute & University of Colorado Boulder.
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Journal ArticleDOI
Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17 458 subjects.
Lisa-Marie Niestroj,Eduardo Pérez-Palma,Daniel P. Howrigan,Yadi Zhou,Feixiong Cheng,Feixiong Cheng,Feixiong Cheng,Elmo Saarentaus,Peter Nürnberg,Remi Stevelink,Mark J. Daly,Mark J. Daly,Aarno Palotie,Aarno Palotie,Dennis Lal,Epi Collaborative +15 more
TL;DR: It is shown that in all common epilepsy types, 1.5-3% of patients carry epilepsy-associated CNVs, and genome-wide genomic testing is advocated to identify all disease-associated types of CNVs.
Journal ArticleDOI
Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia
Elliott Rees,George Kirov,James T.R. Walters,Alexander Richards,Daniel P. Howrigan,David H. Kavanagh,Andrew Pocklington,Menachem Fromer,Menachem Fromer,Douglas M. Ruderfer,Lyudmila Georgieva,Noa Carrera,Padhraig Gormley,Priit Palta,Hywel Williams,S Dwyer,Jessica S. Johnson,Panos Roussos,Douglas Barker,Eric Banks,Milanova,Samuel A. Rose,Kimberly Chambert,Milind Mahajan,Edward M. Scolnick,Jennifer L. Moran,Ming T. Tsuang,Ming T. Tsuang,Stephen J. Glatt,Wei J. Chen,H-G Hwu,Benjamin M. Neale,Benjamin M. Neale,Aarno Palotie,Pamela Sklar,Shaun Purcell,Shaun Purcell,Steven A. McCarroll,Steven A. McCarroll,Peter Holmans,Michael John Owen,Michael Conlon O'Donovan +41 more
TL;DR: It is concluded that recessive genotypes do not appear to make a substantial contribution to schizophrenia at a genome-wide level and requires evaluation in a larger sample of trios.
Posted ContentDOI
Systematic single-variant and gene-based association testing of 3,700 phenotypes in 281,850 UK Biobank exomes
Konrad J. Karczewski,Konrad J. Karczewski,Matthew Solomonson,Matthew Solomonson,Katherine R. Chao,Katherine R. Chao,Julia K. Goodrich,Julia K. Goodrich,Grace Tiao,Grace Tiao,Lu W,Lu W,Riley-Gillis Bm,Ellen A. Tsai,Hye In Kim,Zheng X,Rahimov F,Esmaeeli S,Jason Grundstad A,Mark Reppell,Jeff Waring,Jacob H,David Sexton,Paola G. Bronson,Xing Chen,Hu X,Jacqueline I. Goldstein,Jacqueline I. Goldstein,King D,King D,Vittal C,Vittal C,Timothy Poterba,Timothy Poterba,Duncan S. Palmer,Duncan S. Palmer,Claire Churchhouse,Claire Churchhouse,Daniel P. Howrigan,Daniel P. Howrigan,Wei Zhou,Wei Zhou,Nicholas A. Watts,Nicholas A. Watts,Katrina Nguyen,Katrina Nguyen,Nguyen H,Nguyen H,Mason C,Farnham C,Charlotte Tolonen,Laura D. Gauthier,Namrata Gupta,Daniel G. MacArthur,Heidi L. Rehm,Heidi L. Rehm,Cotton Seed,Cotton Seed,Anthony A. Philippakis,Mark J. Daly,Justin W. Davis,Heiko Runz,Melissa R. Miller,Benjamin M. Neale,Benjamin M. Neale +64 more
TL;DR: In this paper, the full manuscript has been temporarily withdrawn by the authors upon request from UK Biobank and results supporting this manuscript remain valid and can be found at https://genebass.org.
Journal ArticleDOI
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
Emma C. Johnson,Douglas W. Bjelland,Daniel P. Howrigan,Abdel Abdellaoui,Gerome Breen,Anders D. Børglum,Sven Cichon,Franziska Degenhardt,Andreas J. Forstner,Josef Frank,Giulio Genovese,Stefanie Heilmann-Heimbach,Stefan Herms,Per Hoffman,Wolfgang Maier,Manuel Mattheisen,Derek W. Morris,Bryan J. Mowry,Betram Müller-Mhysok,Benjamin M. Neale,Benjamin M. Neale,Igor Nenadic,Markus M. Nöthen,Colm O'Dushlaine,Marcella Rietschel,Douglas M. Ruderfer,Dan Rujescu,Thomas G. Schulze,Matthew A. Simonson,Eli A. Stahl,Eli A. Stahl,Jana Strohmaier,Stephanie H. Witt,Patrick F. Sullivan,Matthew C. Keller +34 more
TL;DR: Repl replication results from 22 independent schizophrenia case-control datasets from the Psychiatric Genomics Consortium are described, unable to replicate the significant association between ROH burden and schizophrenia in the independent PGC phase II data, although the effect was in the predicted direction.
Posted ContentDOI
Paternal-age-related de novo mutations and risk for five disorders
Jacob Taylor,Jean-Christophe Debost,Sarah U. Morton,Emilie M. Wigdor,Henrike O. Heyne,Dennis Lal,Daniel P. Howrigan,Alex Bloemendal,Janne Tidselbak Larsen,Jack A. Kosmicki,Daniel J. Weiner,Jason Homsy,Jonathan G. Seidman,Christine E. Seidman,Esben Agerbo,John J. McGrath,Preben Bo Mortensen,Liselotte Petersen,Mark J. Daly,Elise B. Robinson +19 more
TL;DR: The degree to which the epidemiologic association between each disorder and advanced paternal age was consistent with the estimated role of de novo mutations was investigated was investigated to clarify the clinical and public health significance of delayed paternity.