F
Frank J. Manion
Researcher at University of Michigan
Publications - 35
Citations - 1613
Frank J. Manion is an academic researcher from University of Michigan. The author has contributed to research in topics: Ontology (information science) & Genome-wide association study. The author has an hindex of 16, co-authored 33 publications receiving 1407 citations. Previous affiliations of Frank J. Manion include Chonnam National University & University of Texas Health Science Center at Houston.
Papers
More filters
Journal ArticleDOI
A comprehensive human linkage map with centimorgan density
Jeffrey C. Murray,Kenneth H. Buetow,James L. Weber,Susan Ludwigsen,T. Scherpbier-Heddema,Frank J. Manion,J Quillen,Val C. Sheffield,Sara L.F. Sunden,Geoffrey M. Duyk +9 more
TL;DR: A comprehensive human linkage map is presented here, consisting of 5840 loci, of which 970 are uniquely ordered, covering 4000 centimorgans on the sex-averaged map and achieving one of the first goals of the Human Genome Project--a comprehensive, high-density genetic map.
Journal ArticleDOI
Genome-wide association study of colorectal cancer identifies six new susceptibility loci
Fredrick R. Schumacher,Stephanie L. Schmit,Shuo Jiao,Christopher K. Edlund,Hansong Wang,Ben Zhang,Li Hsu,Shu Chen Huang,Christopher P. Fischer,John F. Harju,Gregory Idos,Flavio Lejbkowicz,Frank J. Manion,Kevin McDonnell,Caroline McNeil,Marilena Melas,Hedy S. Rennert,Wei Shi,Duncan C. Thomas,David Van Den Berg,Carolyn M. Hutter,Aaron K. Aragaki,Katja Butterbach,Bette J. Caan,Christopher S. Carlson,Stephen J. Chanock,Keith R. Curtis,Charles S. Fuchs,Manish Gala,Edward L. Giocannucci,Stephanie M. Gogarten,Richard B. Hayes,Brian E. Henderson,David J. Hunter,Rebecca D. Jackson,Laurence N. Kolonel,Charles Kooperberg,Sebastian Kury,Andrea Z. LaCroix,Cathy C. Laurie,Cecelia A. Laurie,Mathiew Lemire,David K. Levine,Jing Ma,Karen W. Makar,Conghui Qu,Darin Taverna,Cornelia M. Ulrich,Cornelia M. Ulrich,Cornelia M. Ulrich,Kana Wu,Suminori Kono,Dee W. West,Sonja I. Berndt,Stéphane Bézieau,Hermann Brenner,Peter T. Campbell,Andrew T. Chan,Jenny Chang-Claude,Gerhard A. Coetzee,David V. Conti,David Duggan,Jane C. Figueiredo,Barbara K. Fortini,Steven Gallinger,W. James Gauderman,Graham G. Giles,Roger C. Green,Robert W. Haile,Tabitha A. Harrison,Michael Hoffmeister,John L. Hopper,Thomas J. Hudson,Eric J. Jacobs,Motoki Iwasaki,Sun Ha Jee,Mark A. Jenkins,Wei Hua Jia,Amit Joshi,Li Li,N. M. Lindor,Keitaro Matsuo,Victor Moreno,Bhramar Mukherjee,Polly A. Newcomb,John D. Potter,Leon Raskin,Leon Raskin,Gad Rennert,Stephanie A. Rosse,Gianluca Severi,Robert E. Schoen,Daniela Seminara,Xiao-Ou Shu,Martha L. Slattery,Shoichiro Tsugane,Emily White,Yong-Bing Xiang,Brent W. Zanke,Wei Zheng,Loic Le Marchand,Graham Casey,Stephen B. Gruber,Ulrike Peters +103 more
TL;DR: Six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08 are described, providing additional insight into the underlying biological mechanisms of colorectal cancer and demonstrating the scientific value of large consortia-based genetic epidemiology studies.
Journal ArticleDOI
Novel Common Genetic Susceptibility Loci for Colorectal Cancer
Stephanie L. Schmit,Christopher K. Edlund,Fredrick R. Schumacher,Jian Gong,Tabitha A. Harrison,Jeroen R. Huyghe,Chenxu Qu,Marilena Melas,David Van Den Berg,Hansong Wang,Stephanie Tring,Sarah J. Plummer,Demetrius Albanes,M. Henar Alonso,Christopher I. Amos,Kristen Anton,Aaron K. Aragaki,Volker Arndt,Elizabeth L. Barry,Sonja I. Berndt,Stéphane Bézieau,Stephanie A. Bien,Amanda Bloomer,Juergen Boehm,Marie-Christine Boutron-Ruault,Marie-Christine Boutron-Ruault,Hermann Brenner,Stefanie Brezina,Daniel D. Buchanan,Daniel D. Buchanan,Katja Butterbach,Bette J. Caan,Peter T. Campbell,Chris S. Carlson,Jose E. Castelao,Andrew T. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Stephen J. Chanock,Iona Cheng,Ya Wen Cheng,Lee Soo Chin,James M. Church,Timothy R. Church,Gerhard A. Coetzee,Michelle Cotterchio,Marcia Cruz Correa,Keith R. Curtis,David Duggan,Douglas F. Easton,Dallas R. English,Edith J. M. Feskens,Rocky Fischer,Liesel M. FitzGerald,Liesel M. FitzGerald,Barbara K. Fortini,Lars G. Fritsche,Lars G. Fritsche,Charles S. Fuchs,Charles S. Fuchs,Manuela Gago-Dominguez,Manish Gala,Steven Gallinger,W. James Gauderman,Graham G. Giles,Graham G. Giles,Edward Giovannucci,Edward Giovannucci,Stephanie M. Gogarten,Clicerio Gonzalez-Villalpando,Elena M. Gonzalez-Villalpando,William M. Grady,Joel K. Greenson,Andrea Gsur,Marc J. Gunter,Christopher A. Haiman,Jochen Hampe,Sophia Harlid,John F. Harju,Richard B. Hayes,Philipp Hofer,Michael Hoffmeister,John L. Hopper,Shu Chen Huang,José María Huerta,Thomas J. Hudson,David J. Hunter,Gregory Idos,Motoki Iwasaki,Rebecca D. Jackson,Eric J. Jacobs,Sun Ha Jee,Mark A. Jenkins,Weihua Jia,Shuo Jiao,Amit Joshi,Laurence N. Kolonel,Suminori Kono,Charles Kooperberg,Vittorio Krogh,Tilman Kuehn,Sébastien Küry,Andrea Z. LaCroix,Cecelia A. Laurie,Flavio Lejbkowicz,Flavio Lejbkowicz,Mathieu Lemire,Heinz-Josef Lenz,David N. Levine,Christopher I. Li,Li Li,Wolfgang Lieb,Yi Lin,Noralane M. Lindor,Yun Ru Liu,Fotios Loupakis,Yingchang Lu,Frank Luh,Jing Ma,Christoph Mancao,Frank J. Manion,Sanford D. Markowitz,Vicente Martín,Koichi Matsuda,Koichi Matsuda,Keitaro Matsuo,Kevin McDonnell,Caroline McNeil,Roger L. Milne,Roger L. Milne,Antonio J. Molina,Bhramar Mukherjee,Neil Murphy,Polly A. Newcomb,Kenneth Offit,Hanane Omichessan,Hanane Omichessan,Domenico Palli,Jesus P. Paredes Cotoré,Julyann Pérez-Mayoral,Paul D.P. Pharoah,John D. Potter,Conghui Qu,Leon Raskin,Gad Rennert,Gad Rennert,Hedy S. Rennert,Bridget M. Riggs,Clemens Schafmayer,Robert E. Schoen,Thomas A. Sellers,Daniela Seminara,Gianluca Severi,Wei Shi,David Shibata,Xiao-Ou Shu,Erin M. Siegel,Martha L. Slattery,Melissa C. Southey,Zsofia K. Stadler,Zsofia K. Stadler,Mariana C. Stern,Sebastian Stintzing,Darin Taverna,Stephen N. Thibodeau,Duncan C. Thomas,Antonia Trichopoulou,Shoichiro Tsugane,Cornelia M. Ulrich,Fränzel J.B. van Duijnhoven,Bethany van Guelpan,Joseph Vijai,Jarmo Virtamo,Stephanie J. Weinstein,Emily White,Aung Ko Win,Alicja Wolk,Michael O. Woods,Anna H. Wu,Kana Wu,Yong-Bing Xiang,Yun Yen,Brent W. Zanke,Brent W. Zanke,Yi Xin Zeng,Ben Zhang,Niha Zubair,Sun-Seog Kweon,Jane C. Figueiredo,Jane C. Figueiredo,Wei Zheng,Loic Le Marchand,Annika Lindblom,Victor Moreno,Ulrike Peters,Graham Casey,Li Hsu,David V. Conti,Stephen B. Gruber +198 more
TL;DR: This article identified 42 loci (P < 5x10−8) associated with risk of colorectal cancer (CRC) and expanded consortium efforts facilitating the discovery of these loci.
Journal ArticleDOI
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk
Chenjie Zeng,Koichi Matsuda,Wei Hua Jia,Jiang Chang,Sun-Seog Kweon,Yong-Bing Xiang,Aesun Shin,Sun Ha Jee,Dong Hyun Kim,Ben Zhang,Qiuyin Cai,Xingyi Guo,Jirong Long,Nan Wang,Nan Wang,Regina Courtney,Zhi Zhong Pan,Chen Wu,Atsushi Takahashi,Min-Ho Shin,Keitaro Matsuo,Fumihiko Matsuda,Yu-Tang Gao,Jae Hwan Oh,Soriul Kim,Keum Ji Jung,Yoon Ok Ahn,Zefang Ren,Hong Lan Li,Jie Wu,Jiajun Shi,Wanqing Wen,Gong Yang,Bingshan Li,Bu Tian Ji,Stephen B. Gruber,Fredrick R. Schumacher,Stephanie L. Stenzel,Graham Casey,John L. Hopper,Mark A. Jenkins,Hyeong Rok Kim,Jin Young Jeong,Ji Won Park,Kazuo Tajima,Sang-Hee Cho,Michiaki Kubo,Xiao-Ou Shu,Dongxin Lin,Yi Xin Zeng,Wei Zheng,Hermann Brenner,Robert E. Schoen,Sébastien Küry,John A. Baron,Sonja I. Berndt,Stéphane Bezieau,Bette J. Caan,Christopher S. Carlson,Andrew T. Chan,Jenny Chang-Claude,Stephen J. Chanock,David V. Conti,Keith R. Curtis,David Duggan,Charles S. Fuchs,Steven Gallinger,Edward Giovannucci,Robert W. Haile,Tabitha A. Harrison,Richard B. Hayes,Michael Hoffmeister,Li Hsu,Thomas J. Hudson,David J. Hunter,Carolyn M. Hutter,Rebecca D. Jackson,Shuo Jiao,Loic Le Marchand,Mathieu Lemire,Noralane M. Lindor,Jing Ma,Polly A. Newcomb,Ulrike Peters,John D. Potter,Conghui Qu,Daniela Seminara,Martha L. Slattery,Stephen N. Thibodeau,Emily White,Brent W. Zanke,Kendra Blalock,Peter T. Campbell,Christopher K. Edlund,Jane C. Figueiredo,W. James Gauderman,Jian Gong,Roger C. Green,John F. Harju,Eric J. Jacobs,Li Li,Yi Lin,Frank J. Manion,Victor Moreno,Bhramar Mukherjee,Leon Raskin,Gianluca Severi,Duncan C. Thomas +107 more
TL;DR: In this article, the authors conducted a genome-wide association study to identify risk loci for colorectal cancer (CRC) and found that the most significant variants in each locus ranged from 3.92 −8 to 1.24 −12.
Journal ArticleDOI
Application of Bayesian decomposition for analysing microarray data.
Thomas D. Moloshok,R. R. Klevecz,Jeffrey D. Grant,Frank J. Manion,William Speier,Michael F. Ochs +5 more
TL;DR: The ability of the algorithm to provide insight into the yeast cell cycle is demonstrated, including identification of five temporal patterns tied to cell cycle phases as well as the identification of a pattern tied to an approximately 40 min cell cycle oscillator.