D
David A. Jackson
Researcher at King's College London
Publications - 1166
Citations - 76015
David A. Jackson is an academic researcher from King's College London. The author has contributed to research in topics: Optical fiber & Interferometry. The author has an hindex of 136, co-authored 1095 publications receiving 68352 citations. Previous affiliations of David A. Jackson include University of California, Berkeley & University of Alberta.
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Journal ArticleDOI
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
Mihaela Skobe,Thomas Hawighorst,David A. Jackson,Remko Prevo,Lauren Janes,Paula Velasco,Lucia Riccardi,Kari Alitalo,Kevin P. Claffey,Michael Detmar +9 more
TL;DR: The occurrence and biological significance of intratumoral lymphangiogenesis within human breast cancers after orthotopic transplantation onto nude mice are established and VEGF-C is identified as a molecular link between tumor lymphang iogenesis and metastasis.
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A conditional knockout resource for the genome-wide study of mouse gene function.
William C. Skarnes,Barry Rosen,Anthony P. West,Manousos Koutsourakis,Wendy Bushell,Vivek Iyer,Alejandro O. Mujica,Alejandro O. Mujica,Mark G. Thomas,Jennifer Harrow,Tony Cox,David A. Jackson,Jessica Severin,Jessica Severin,Patrick J. Biggs,Patrick J. Biggs,Jun Fu,Michael Nefedov,Pieter J. de Jong,A. Francis Stewart,Allan Bradley +20 more
TL;DR: High-throughput genome engineering highlighted by this study is broadly applicable to rat and human stem cells and provides a foundation for future genome-wide efforts aimed at deciphering the function of all genes encoded by the mammalian genome.
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LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan
Suneale Banerji,Jian Ni,Shu-Xia Wang,Steven Clasper,Jeffrey Su,Raija Tammi,Margaret Jones,David A. Jackson +7 more
TL;DR: LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
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Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.
Marika J. Karkkainen,Paula Haiko,Kirsi Sainio,Juha Partanen,Jussi Taipale,Tatiana V. Petrova,Michael Jeltsch,David A. Jackson,Marja Talikka,Heikki Rauvala,Christer Betsholtz,Kari Alitalo +11 more
TL;DR: The results indicate that VEGF-C is the paracrine factor essential for lymphangiogenesis, and show that both Vegfc alleles are required for normal lymphatic development.
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VEGF-D promotes the metastatic spread of tumor cells via the lymphatics.
Steven A. Stacker,Carol Caesar,Megan E. Baldwin,Gillian E. Thornton,Richard A. Williams,Remko Prevo,David A. Jackson,Shin-Ichi Nishikawa,Hajime Kubo,Hajime Kubo,Marc G. Achen +10 more
TL;DR: It is demonstrated that lymphatics can be established in solid tumors and implicates VEGF family members in determining the route of metastatic spread and could be blocked with an antibody specific for V EGF-D.