D
David Alvarez
Researcher at Harvard University
Publications - 45
Citations - 5342
David Alvarez is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & Sensitization. The author has an hindex of 27, co-authored 44 publications receiving 4537 citations. Previous affiliations of David Alvarez include Icahn School of Medicine at Mount Sinai & McMaster University.
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Journal ArticleDOI
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
Frank Tacke,David Alvarez,Theodore J. Kaplan,Claudia Jakubzick,Rainer Spanbroek,Jaime Llodra,Alexandre Garin,Jianhua Liu,Matthias Mack,Nico van Rooijen,Sergio A. Lira,Andreas J. R. Habenicht,Gwendalyn J. Randolph +12 more
TL;DR: Analyzing mouse monocyte subsets in apoE-deficient mice and tracing their differentiation and chemokine receptor usage as they accumulated within atherosclerotic plaques suggests antagonizing CX3CR1 may be effective therapeutically in ameliorating CCR2(+) monocyte recruitment to plaques without impairing their C CR2-dependent responses to inflammation overall.
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Mechanisms and Consequences of Dendritic Cell Migration
TL;DR: The molecular traffic signals that govern the migration of DCs throughout their life cycle are reviewed and it is shown that within peripheral tissues, DCs collect antigenic material and then traffic to secondary lymphoid organs, where they communicate with lymphocytes to orchestrate adaptive immune responses.
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Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation
Lorena Riol-Blanco,Jose Ordovas-Montanes,Mario Perro,Elena Naval,Aude Thiriot,David Alvarez,Silke Paust,John N. Wood,Ulrich H. von Andrian +8 more
TL;DR: Findings indicate that TRPV1+Nav1.8+ nociceptors, by interacting with DDCs, regulate the IL-23/IL-17 pathway and control cutaneous immune responses.
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The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis
Carmen Gerlach,E. Ashley Moseman,Scott Loughhead,David Alvarez,Anthonie J. Zwijnenburg,Lisette Waanders,Rohit Garg,Juan Carlos de la Torre,Ulrich H. von Andrian,Ulrich H. von Andrian +9 more
TL;DR: A subset of CX3CR1int Tmem cells present unique phenotypic, homeostatic, and migratory properties, and it is proposed that tpm cells are chiefly responsible for the global surveillance of non-lymphoid tissues.
Journal ArticleDOI
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Moshe Biton,Moshe Biton,Adam L. Haber,Noga Rogel,Grace Burgin,Semir Beyaz,Semir Beyaz,Semir Beyaz,Alexandra Schnell,Orr Ashenberg,Chien-wen Su,Christopher Smillie,Karthik Shekhar,Zuojia Chen,Chuan Wu,Jose Ordovas-Montanes,David Alvarez,Rebecca H. Herbst,Rebecca H. Herbst,Mei Zhang,Itay Tirosh,Itay Tirosh,Danielle Dionne,Lan T. Nguyen,Michael E. Xifaras,Alex K. Shalek,Ulrich H. von Andrian,Daniel B. Graham,Orit Rozenblatt-Rosen,Hai Ning Shi,Vijay K. Kuchroo,Vijay K. Kuchroo,Ömer H. Yilmaz,Ömer H. Yilmaz,Ömer H. Yilmaz,Aviv Regev,Aviv Regev,Ramnik J. Xavier +37 more
TL;DR: It is shown that MHCII+ Lgr5+ ISCs are non-conventional antigen-presenting cells in co-cultures with CD4+ T helper (Th) cells, which orchestrate tissue-wide responses to external signals.