Richard Packer

TL;DR: In this paper, a genome-wide association study in 400,102 individuals of European ancestry was conducted to define 279 lung function signals, 139 of which are new and the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups.

TL;DR: It is found that substantial shared genetic architecture between mild and moderate-to-severe asthma is found and candidate causal genes in these loci are identified and provide increased insight into this difficult to treat population.

TL;DR: A genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries reveals compelling insights regarding disease susceptibility and severity.

TL;DR: A genome-wide association study in 400,102 individuals of European ancestry defines 279 lung function signals that strongly predict COPD in deeply-phenotyped patient populations and the combined effect of these variants showed generalisability across smokers and never-smokers, and across ancestral groups.

TL;DR: The resource requires completion of a proposal form, including a lay summary of the proposed research, and applications to access the resource will be assessed for consistency with the data access policy and with the guidance of the Scientific Committee, which has participant representation.