D
Diego Jaitin
Researcher at Weizmann Institute of Science
Publications - 48
Citations - 10017
Diego Jaitin is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Chromatin & Immune system. The author has an hindex of 26, co-authored 45 publications receiving 7394 citations.
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Journal ArticleDOI
Host microbiota constantly control maturation and function of microglia in the CNS
Daniel Erny,Anna Lena Hrabě de Angelis,Diego Jaitin,Peter Wieghofer,Ori Staszewski,Eyal David,Hadas Keren-Shaul,Tanel Mahlakõiv,Kristin Jakobshagen,Thorsten Buch,Vera Schwierzeck,Olaf Utermöhlen,Eunyoung Chun,Wendy S. Garrett,Kathy D. McCoy,Andreas Diefenbach,Peter Staeheli,Bärbel Stecher,Ido Amit,Marco Prinz +19 more
TL;DR: It is determined that short-chain fatty acids (SCFA), microbiota-derived bacterial fermentation products, regulated microglia homeostasis and mice deficient for the SCFA receptor FFAR2 mirroredmicroglia defects found under GF conditions, suggesting that host bacteria vitally regulate microglian maturation and function.
Journal ArticleDOI
Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types
Diego Jaitin,Ephraim Kenigsberg,Hadas Keren-Shaul,Naama Elefant,Franziska Paul,Irina Zaretsky,Alexander Mildner,Nadav Cohen,Steffen Jung,Amos Tanay,Ido Amit +10 more
TL;DR: An automated massively parallel single-cell RNA sequencing approach for analyzing in vivo transcriptional states in thousands of single cells is introduced and provides the ability to perform a bottom-up characterization of in vivo cell-type landscapes independent of cell markers or prior knowledge.
Journal ArticleDOI
m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
Shay Geula,Sharon Moshitch-Moshkovitz,Dan Dominissini,Abed AlFatah Mansour,Nitzan Kol,Mali Salmon-Divon,Vera Hershkovitz,Eyal Peer,Nofar Mor,Yair S. Manor,Moshe Shay Ben-Haim,Eran Eyal,Sharon Yunger,Yishay Pinto,Diego Jaitin,Sergey Viukov,Yoach Rais,Vladislav Krupalnik,Elad Chomsky,Mirie Zerbib,Itay Maza,Yoav Rechavi,Rada Massarwa,Suhair Hanna,Suhair Hanna,Ido Amit,Erez Y. Levanon,Ninette Amariglio,Ninette Amariglio,Noam Stern-Ginossar,Noa Novershtern,Gideon Rechavi,Jacob H. Hanna +32 more
TL;DR: It is shown that N6-methyladenosine (m6A), a messenger RNA (mRNA) modification present on transcripts of pluripotency factors, drives this transition from the pluripotent to the differentiated state.
Journal ArticleDOI
Chromatin state dynamics during blood formation
David Lara-Astiaso,Assaf Weiner,Erika Lorenzo-Vivas,Irina Zaretsky,Diego Jaitin,Eyal David,Hadas Keren-Shaul,Alexander Mildner,Deborah R. Winter,Steffen Jung,Nir Friedman,Ido Amit +11 more
TL;DR: A high-sensitivity indexing-first chromatin immunoprecipitation approach to profile the dynamics of four chromatin modifications across 16 stages of hematopoietic differentiation and reveals that lineage commitment involves de novo establishment of 17,035 lineage-specific enhancers.
Journal ArticleDOI
Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner
Diego Jaitin,Lorenz Adlung,Christoph A. Thaiss,Assaf Weiner,Baoguo Li,Hélène Descamps,Patrick Lundgren,Camille Blériot,Zhaoyuan Liu,Aleksandra Deczkowska,Hadas Keren-Shaul,Eyal David,Niv Zmora,Shai Meron Eldar,Nir Lubezky,Oren Shibolet,David A. Hill,David A. Hill,Mitchell A. Lazar,Marco Colonna,Florent Ginhoux,Florent Ginhoux,Hagit Shapiro,Eran Elinav,Ido Amit +24 more
TL;DR: These findings identify Trem2 signaling as a major pathway by which macrophages respond to loss of tissue-level lipid homeostasis, highlighting Trem2 as a key sensor of metabolic pathologies across multiple tissues and a potential therapeutic target in metabolic diseases.