E. Aubrey Thompson

TL;DR: The complete SEQC data sets, comprising >100 billion reads, provide unique resources for evaluating RNA-seq analyses for clinical and regulatory settings, and measurement performance depends on the platform and data analysis pipeline, and variation is large for transcript-level profiling.

TL;DR: It is reported that the sensitivity to TGF-β-induced apoptosis is regulated by crosstalk between the Akt/PKB serine/threonine kinase and Smad3 through a mechanism that is independent of Akt kinase activity.

TL;DR: The developed MAP-RSeq workflow is a comprehensive computational workflow that can be used for obtaining genomic features from transcriptomic sequencing data, for any genome, and has thus far enabled clinicians and researchers to understand the transcriptomic landscape of diseases for better diagnosis and treatment of patients.

TL;DR: In this paper, two oncogenes coamplified on chromosome 3q26, PRKCI and SOX2, cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC).

TL;DR: The data demonstrate that PKCι is a critical lung cancer gene that activates a Rac1→Pak→Mek1, 2→Erk1,2 signaling pathway required for transformed growth, and indicate thatPKCι may be an attractive molecular target for mechanism-based therapies for treatment of lung cancer.