E
Edward J. Dick
Researcher at Texas Biomedical Research Institute
Publications - 144
Citations - 3218
Edward J. Dick is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Baboon & Esophagus. The author has an hindex of 25, co-authored 134 publications receiving 2396 citations. Previous affiliations of Edward J. Dick include Wilford Hall Medical Center.
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Journal ArticleDOI
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters
Alina Baum,Dharani Ajithdoss,Richard Copin,Anbo Zhou,Kathryn Lanza,Nicole Negron,Min Ni,Yi Wei,Kusha Mohammadi,Bret J Musser,Gurinder S. Atwal,Adelekan Oyejide,Yenny Goez-Gazi,John Dutton,Elizabeth Clemmons,Hilary M. Staples,Carmen Bartley,Benjamin Klaffke,Kendra J. Alfson,Michal Gazi,Olga Gonzalez,Edward J. Dick,Ricardo Carrion,Laurent Pessaint,Maciel Porto,Anthony L. Cook,Renita Brown,Vaneesha Ali,Jack Greenhouse,Tammy Taylor,Hanne Leth Andersen,Mark G. Lewis,Neil Stahl,Andrew J. Murphy,George D. Yancopoulos,Christos A. Kyratsous +35 more
TL;DR: It is demonstrated that REGN-COV-2 can greatly reduce virus load in the lower and upper airways and decrease virus-induced pathological sequelae when administered prophylactically or therapeutically in rhesus macaques and golden hamsters.
Journal ArticleDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Fatai S. Oladunni,Jun-Gyu Park,Paula A. Pino,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Xavier Alvarez,Deepak Kaushal,Luis D. Giavedoni,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.
Journal ArticleDOI
Brucella papionis sp. nov., isolated from baboons (Papio spp.).
Adrian M. Whatmore,Nicholas J. Davison,Axel Cloeckaert,Axel Cloeckaert,Sascha Al Dahouk,Michel S. Zygmunt,Michel S. Zygmunt,Simon D. Brew,Lorraine L. Perrett,Mark S. Koylass,Gilles Vergnaud,Gilles Vergnaud,Christine Quance,Holger C. Scholz,Edward J. Dick,Gene B. Hubbard,Natalia Schlabritz-Loutsevitch +16 more
TL;DR: Two Gram-negative, non-motile,non-spore-forming coccoid bacteria isolated from clinical specimens obtained from baboons that had delivered stillborn offspring were subjected to a polyphasic taxonomic study and represented a novel lineage within the genus Brucella.
Journal ArticleDOI
Pancreatic islet amyloidosis, β-cell apoptosis, and α-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons
Rodolfo Guardado-Mendoza,Alberto M. Davalli,Alberto O. Chavez,Gene B. Hubbard,Edward J. Dick,Abraham Majluf-Cruz,Carlos Enrique Tene-Pérez,Lukasz Goldschmidt,John Hart,Carla Perego,Anthony G. Comuzzie,Maria Elizabeth Tejero,Giovanna Finzi,Claudia Placidi,Stefano La Rosa,Carlo Capella,Glenn A. Halff,Amalia Gastaldelli,Ralph A. DeFronzo,Franco Folli +19 more
TL;DR: The results strongly support the concept that IA and β-cell apoptosis in concert with α-cell proliferation and hypertrophy are key determinants of islets of Langerhans “dysfunctional remodeling” and hyperglycemia in the baboon, a nonhuman primate model of type-2 diabetes mellitus.
Posted ContentDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice
Fatai S. Oladunni,Jun-Gyu Park,Paula Pino Tamayo,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Deepak Kaushal,Luis D. Giavedoni,Xavier Alvarez,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: K18 hACE2-transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS/COVID-19 disease.