E
Elemi J. Breetvelt
Researcher at Utrecht University
Publications - 25
Citations - 1330
Elemi J. Breetvelt is an academic researcher from Utrecht University. The author has contributed to research in topics: Population & Schizophrenia. The author has an hindex of 13, co-authored 23 publications receiving 1084 citations. Previous affiliations of Elemi J. Breetvelt include Centre for Addiction and Mental Health & University Health Network.
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Journal ArticleDOI
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Gunter Schumann,Lachlan J. M. Coin,Anbarasu Lourdusamy,Pimphen Charoen,Pimphen Charoen,Karen H. Berger,David Stacey,Sylvane Desrivières,Fazil Aliev,Anokhi Ali Khan,Najaf Amin,Yurii S. Aulchenko,Georgy Bakalkin,Stephan J. L. Bakker,Beverley Balkau,Beverley Balkau,Joline W.J. Beulens,Ainhoa Bilbao,Rudolf A. de Boer,Delphine Beury,Michiel L. Bots,Elemi J. Breetvelt,Stéphane Cauchi,Christine Cavalcanti-Proença,John C. Chambers,Toni-Kim Clarke,Norbert Dahmen,Eco J. C. de Geus,Danielle M. Dick,Francesca Ducci,Alanna C. Easton,Howard J. Edenberg,Tõnu Esko,Alberto Fernández-Medarde,Tatiana Foroud,Nelson B. Freimer,Jean-Antoine Girault,Diederick E. Grobbee,Simonetta Guarrera,Daniel F. Gudbjartsson,Anna-Liisa Hartikainen,Andrew C. Heath,Victor Hesselbrock,Albert Hofman,Jouke-Jan Hottenga,Matti Isohanni,Jaakko Kaprio,Kay-Tee Khaw,Brigitte Kuehnel,Jaana Laitinen,Stéphane Lobbens,Jian'an Luan,Massimo Mangino,Matthieu Maroteaux,Giuseppe Matullo,Mark I. McCarthy,Christian Mueller,Christian Mueller,Gerjan Navis,Mattijs E. Numans,Alejandro Núñez,Dale R. Nyholt,Charlotte Onland-Moret,Charlotte Onland-Moret,Ben A. Oostra,Paul F. O'Reilly,Miklós Palkovits,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Silvia Polidoro,Anneli Pouta,Inga Prokopenko,Fulvio Ricceri,Eugenio Santos,Johannes H. Smit,Nicole Soranzo,Nicole Soranzo,Kijoung Song,Ulla Sovio,Michael Stumvoll,Ida Surakk,Thorgeir E. Thorgeirsson,Unnur Thorsteinsdottir,Claire Troakes,Thorarinn Tyrfingsson,Anke Tönjes,Cuno S.P.M. Uiterwaal,André G. Uitterlinden,Pim van der Harst,Yvonne T. van der Schouw,Oliver Staehlin,Nicole Vogelzangs,Peter Vollenweider,Gérard Waeber,Nicholas J. Wareham,Dawn M. Waterworth,John Whitfield,Erich Wichmann,Gonneke Willemsen,Jacqueline C.M. Witteman,Xin Yuan,Guangju Zhai,Jing Hua Zhao,Weihua Zhang,Nicholas G. Martin,Andres Metspalu,Angela Doering,James Scott,Tim D. Spector,Ruth J. F. Loos,Dorret I. Boomsma,Vincent Mooser,Leena Peltonen,Leena Peltonen,Kari Stefansson,Cornelia M. van Duijn,Paolo Vineis,Wolfgang H. Sommer,Jaspal S. Kooner,Rainer Spanagel,Ulrike Heberlein,Marjo-Riitta Järvelin,Paul Elliott +122 more
TL;DR: A genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption among 12 population-based samples of European ancestry finds a genotype-specific expression of AUTS2 in 96 human prefrontal cortex samples and finds a regulator of alcohol consumption.
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Gunter Schumann,Lachlan J. M. Coin,Anbarasu Lourdusamy,Pimphen Charoen,Karen H. Berger,David Stacey,Sylvane Desrivières,Fazil Aliev,Anokhi Ali Khan,Najaf Amin,Yurii S. Aulchenko,Georgy Bakalkin,Stephan J. L. Bakker,Beverley Balkau,Joline W.J. Beulens,Ainhoa Bilbao,Rudolf A. de Boer,Delphine Beury,Michiel L. Bots,Elemi J. Breetvelt,Stéphane Cauchi,Christine Cavalcanti-Proença,John C. Chambers,Toni-Kim Clarke,Norbert Dahmen,Eco J. C. de Geus,Danielle M. Dick,Francesca Ducci,Alanna C. Easton,Howard J. Edenberg,Tonu Esk,Alberto Fernández-Medarde,Tatiana Foroud,Nelson B. Freimer,Jean-Antoine Girault,Diederick E. Grobbee,Simonetta Guarrera,Daniel F. Gudbjartsson,Anna-Liisa Hartikainen,Andrew Heath,Victor Hesselbrock,Albert Hofman,Jouke-Jan Hottenga,Matti Isohanni,Jaakko Kaprio,Kay-Tee Khaw,Brigitte Kuehnel,Jaana Laitinen,Stéphane Lobbens,Jian'an Luan,Massimo Mangino,Matthieu Maroteaux,Giuseppe Matullo,Mark I. McCarthy,Christian Mueller,Gerjan Navis,Mattijs E. Numans,Alejandro Núñez,Dale R. Nyholt,Charlotte Onland-Moret,Ben A. Oostra,Paul F. O'Reilly,Miklós Palkovits,Brenda W.J.H. Penninx,Silvia Polidoro,Anneli Pouta,Inga Prokopenko,Fulvio Ricceri,Eugenio Santos,Johannes H. Smit,Nicole Soranzo,Kijoung Song,Ulla Sovio,Michael Stumvoll,Ida Surakk,Thorgeir E. Thorgeirsson,Unnur Thorsteinsdottir,Claire Troakes,Thorarinn Tyrfingsson,Anke Toenjes,Cuno S.P.M. Uiterwaal,André G. Uitterlinden,Pim van der Harst,Yvonne T. van der Schouw,Oliver Staehlin,Nicole Vogelzangs,Peter Vollenweider,Gérard Waeber,Nicholas J. Wareham,Dawn M. Waterworth,John Whitfield,Erich Wichmann,Gonneke Willemsen,Jacqueline C.M. Witteman,Xin Yuan,Guangju Zhai,Jing Hua Zhao,Weihua Zhang,Nicholas G. Martin,Andres Metspalu,Angela Doering,James F. Scott,Tim D. Spector,Ruth J. F. Loos,Dorret I. Boomsma,Vincent Mooser,Leena Peltonen,Kari Stefansson,Cornelia M. van Duijn,Paolo Vineis,Wolfgang H. Sommer,Jaspal S. Kooner,Rainer Spanagel,Ulrike Heberlein,Marjo-Riitta Järvelin,Paul Elliott +115 more
Journal ArticleDOI
Cognitive Decline Preceding the Onset of Psychosis in Patients With 22q11.2 Deletion Syndrome
Jacob A. S. Vorstman,Elemi J. Breetvelt,Sasja N. Duijff,Stephan Eliez,Maude Schneider,Maria Jalbrzikowski,Maria Jalbrzikowski,Marco Armando,Stefano Vicari,Vandana Shashi,Stephen R. Hooper,Eva W.C. Chow,Eva W.C. Chow,Wai Lun Alan Fung,Nancy J. Butcher,Nancy J. Butcher,Donald A. Young,Donald A. Young,Donna M. McDonald-McGinn,Annick Vogels,Therese van Amelsvoort,Doron Gothelf,Doron Gothelf,Ronnie Weinberger,Ronnie Weinberger,Abraham Weizman,Petra W.J. Klaassen,Sanne Koops,Wendy R. Kates,Kevin M. Antshel,Kevin M. Antshel,Tony J. Simon,Opal Y. Ousley,Ann Swillen,Raquel E. Gur,Carrie E. Bearden,Carrie E. Bearden,René S. Kahn,Anne S. Bassett +38 more
TL;DR: In 22q11DS, early cognitive decline is a robust indicator of the risk of developing a psychotic illness, and these findings mirror those observed in idiopathic schizophrenia.
Journal ArticleDOI
Early interventions in risk groups for schizophrenia: what are we waiting for?
Iris E. C. Sommer,Carrie E. Bearden,Edwin van Dellen,Elemi J. Breetvelt,Sasja N. Duijff,Kim Maijer,Therese van Amelsvoort,Lieuwe de Haan,Raquel E. Gur,Celso Arango,Covadonga M. Díaz-Caneja,Christiaan H. Vinkers,Jacob A. S. Vorstman +12 more
TL;DR: In this article, the authors investigated preventive interventions in high-risk children to mitigate or prevent the development of schizophrenia and related psychiatric disorders, and showed that the preventive interventions could improve stress resilience, optimize brain maturation, and prevent or alleviate adverse environmental circumstances.
Journal ArticleDOI
Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome.
Robert W. Davies,Robert W. Davies,Ania Fiksinski,Ania Fiksinski,Elemi J. Breetvelt,Nigel Williams,Stephen R. Hooper,Thomas Monfeuga,Anne S. Bassett,Anne S. Bassett,Anne S. Bassett,Michael John Owen,Raquel E. Gur,Bernice E. Morrow,Donna M. McDonald-McGinn,Donna M. McDonald-McGinn,Ann Swillen,Eva W.C. Chow,Eva W.C. Chow,Marianne Bernadette van den Bree,Beverly S. Emanuel,Joris Vermeesch,Therese van Amelsvoort,Celso Arango,Marco Armando,Linda E. Campbell,Joseph F. Cubells,Stephan Eliez,Sixto García-Miñaur,Doron Gothelf,Doron Gothelf,Wendy R. Kates,Kieran C. Murphy,Clodagh M. Murphy,Declan G. Murphy,Nicole Philip,Gabriela M. Repetto,Vandana Shashi,Tony J. Simon,Damian Heine Suñer,Stefano Vicari,Stephen W. Scherer,Carrie E. Bearden,Jacob A. S. Vorstman,Jacob A. S. Vorstman +44 more
TL;DR: Data show a shared genetic basis for schizophrenia and schizophrenia-related phenotypes and also highlight the future potential of polygenic scores for risk stratification among individuals with highly, but incompletely, penetrant genetic variants.