K
Karen H. Berger
Researcher at University of California, San Francisco
Publications - 11
Citations - 1009
Karen H. Berger is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 11, co-authored 11 publications receiving 955 citations.
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Journal ArticleDOI
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Gunter Schumann,Lachlan J. M. Coin,Anbarasu Lourdusamy,Pimphen Charoen,Pimphen Charoen,Karen H. Berger,David Stacey,Sylvane Desrivières,Fazil Aliev,Anokhi Ali Khan,Najaf Amin,Yurii S. Aulchenko,Georgy Bakalkin,Stephan J. L. Bakker,Beverley Balkau,Beverley Balkau,Joline W.J. Beulens,Ainhoa Bilbao,Rudolf A. de Boer,Delphine Beury,Michiel L. Bots,Elemi J. Breetvelt,Stéphane Cauchi,Christine Cavalcanti-Proença,John C. Chambers,Toni-Kim Clarke,Norbert Dahmen,Eco J. C. de Geus,Danielle M. Dick,Francesca Ducci,Alanna C. Easton,Howard J. Edenberg,Tõnu Esko,Alberto Fernández-Medarde,Tatiana Foroud,Nelson B. Freimer,Jean-Antoine Girault,Diederick E. Grobbee,Simonetta Guarrera,Daniel F. Gudbjartsson,Anna-Liisa Hartikainen,Andrew C. Heath,Victor Hesselbrock,Albert Hofman,Jouke-Jan Hottenga,Matti Isohanni,Jaakko Kaprio,Kay-Tee Khaw,Brigitte Kuehnel,Jaana Laitinen,Stéphane Lobbens,Jian'an Luan,Massimo Mangino,Matthieu Maroteaux,Giuseppe Matullo,Mark I. McCarthy,Christian Mueller,Christian Mueller,Gerjan Navis,Mattijs E. Numans,Alejandro Núñez,Dale R. Nyholt,Charlotte Onland-Moret,Charlotte Onland-Moret,Ben A. Oostra,Paul F. O'Reilly,Miklós Palkovits,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Silvia Polidoro,Anneli Pouta,Inga Prokopenko,Fulvio Ricceri,Eugenio Santos,Johannes H. Smit,Nicole Soranzo,Nicole Soranzo,Kijoung Song,Ulla Sovio,Michael Stumvoll,Ida Surakk,Thorgeir E. Thorgeirsson,Unnur Thorsteinsdottir,Claire Troakes,Thorarinn Tyrfingsson,Anke Tönjes,Cuno S.P.M. Uiterwaal,André G. Uitterlinden,Pim van der Harst,Yvonne T. van der Schouw,Oliver Staehlin,Nicole Vogelzangs,Peter Vollenweider,Gérard Waeber,Nicholas J. Wareham,Dawn M. Waterworth,John Whitfield,Erich Wichmann,Gonneke Willemsen,Jacqueline C.M. Witteman,Xin Yuan,Guangju Zhai,Jing Hua Zhao,Weihua Zhang,Nicholas G. Martin,Andres Metspalu,Angela Doering,James Scott,Tim D. Spector,Ruth J. F. Loos,Dorret I. Boomsma,Vincent Mooser,Leena Peltonen,Leena Peltonen,Kari Stefansson,Cornelia M. van Duijn,Paolo Vineis,Wolfgang H. Sommer,Jaspal S. Kooner,Rainer Spanagel,Ulrike Heberlein,Marjo-Riitta Järvelin,Paul Elliott +122 more
TL;DR: A genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption among 12 population-based samples of European ancestry finds a genotype-specific expression of AUTS2 in 96 human prefrontal cortex samples and finds a regulator of alcohol consumption.
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Gunter Schumann,Lachlan J. M. Coin,Anbarasu Lourdusamy,Pimphen Charoen,Karen H. Berger,David Stacey,Sylvane Desrivières,Fazil Aliev,Anokhi Ali Khan,Najaf Amin,Yurii S. Aulchenko,Georgy Bakalkin,Stephan J. L. Bakker,Beverley Balkau,Joline W.J. Beulens,Ainhoa Bilbao,Rudolf A. de Boer,Delphine Beury,Michiel L. Bots,Elemi J. Breetvelt,Stéphane Cauchi,Christine Cavalcanti-Proença,John C. Chambers,Toni-Kim Clarke,Norbert Dahmen,Eco J. C. de Geus,Danielle M. Dick,Francesca Ducci,Alanna C. Easton,Howard J. Edenberg,Tonu Esk,Alberto Fernández-Medarde,Tatiana Foroud,Nelson B. Freimer,Jean-Antoine Girault,Diederick E. Grobbee,Simonetta Guarrera,Daniel F. Gudbjartsson,Anna-Liisa Hartikainen,Andrew Heath,Victor Hesselbrock,Albert Hofman,Jouke-Jan Hottenga,Matti Isohanni,Jaakko Kaprio,Kay-Tee Khaw,Brigitte Kuehnel,Jaana Laitinen,Stéphane Lobbens,Jian'an Luan,Massimo Mangino,Matthieu Maroteaux,Giuseppe Matullo,Mark I. McCarthy,Christian Mueller,Gerjan Navis,Mattijs E. Numans,Alejandro Núñez,Dale R. Nyholt,Charlotte Onland-Moret,Ben A. Oostra,Paul F. O'Reilly,Miklós Palkovits,Brenda W.J.H. Penninx,Silvia Polidoro,Anneli Pouta,Inga Prokopenko,Fulvio Ricceri,Eugenio Santos,Johannes H. Smit,Nicole Soranzo,Kijoung Song,Ulla Sovio,Michael Stumvoll,Ida Surakk,Thorgeir E. Thorgeirsson,Unnur Thorsteinsdottir,Claire Troakes,Thorarinn Tyrfingsson,Anke Toenjes,Cuno S.P.M. Uiterwaal,André G. Uitterlinden,Pim van der Harst,Yvonne T. van der Schouw,Oliver Staehlin,Nicole Vogelzangs,Peter Vollenweider,Gérard Waeber,Nicholas J. Wareham,Dawn M. Waterworth,John Whitfield,Erich Wichmann,Gonneke Willemsen,Jacqueline C.M. Witteman,Xin Yuan,Guangju Zhai,Jing Hua Zhao,Weihua Zhang,Nicholas G. Martin,Andres Metspalu,Angela Doering,James F. Scott,Tim D. Spector,Ruth J. F. Loos,Dorret I. Boomsma,Vincent Mooser,Leena Peltonen,Kari Stefansson,Cornelia M. van Duijn,Paolo Vineis,Wolfgang H. Sommer,Jaspal S. Kooner,Rainer Spanagel,Ulrike Heberlein,Marjo-Riitta Järvelin,Paul Elliott +115 more
Journal ArticleDOI
An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol.
Amy W. Lasek,Jana P. Lim,Christopher L. Kliethermes,Karen H. Berger,Geoff Joslyn,Gerry Brush,Liquan Xue,Margaret Robertson,Monica S. Moore,Karen Vranizan,Stephan W. Morris,Marc A. Schuckit,Raymond L. White,Ulrike Heberlein +13 more
TL;DR: The results suggest that Alk plays an evolutionary conserved role in ethanol-related behaviors and may be a novel candidate gene conferring risk for AUDs as well as a potential target for pharmacological intervention.
Journal ArticleDOI
Happyhour, a Ste20 Family Kinase, Implicates EGFR Signaling in Ethanol-Induced Behaviors
Ammon B. Corl,Karen H. Berger,Galit Ophir-Shohat,Julie Gesch,Jeffrey A. Simms,Selena E. Bartlett,Ulrike Heberlein +6 more
TL;DR: Genetic and biochemical experiments revealed that the epidermal growth factor (EGF)-signaling pathway regulates ethanol sensitivity in Drosophila and that Hppy functions as an inhibitor of the pathway.
Journal ArticleDOI
Rapid and chronic: two distinct forms of ethanol tolerance in Drosophila.
TL;DR: The utility of Drosophila, with its accessibility to genetic, molecular, and behavioral analyses, as a model organism to study tolerance development in response to different ethanol-exposure regimens, is explored.