Eric J. Topol

TL;DR: In this paper, the authors assessed the outcome of patients with acute myocardial infarction (MI) and bundle branch block in the thrombolytic era and reported high mortality rates and poor overall prognosis.

TL;DR: Treatment with clopidogrel results in a significant decrease in the need for rehospitalization for ischemic events or bleeding compared with aspirin, and this meaningful end point tracks well with other, more traditional measures of outcome and has incremental value beyond such end points.

TL;DR: The GRAVITAS trial is the first large-scale clinical trial designed to examine whether adjustment of clopidogrel therapy on the basis of platelet function testing using a point-of-care assay safely improves outcomes after PCI with DES.

TL;DR: This editorial describes a quantitative paradigm for remodeling analyses: as arterial plaque or neointima forms in an artery, it is accompanied by luminal encroachment, artery expansion or gradations of either and is generally defined as any arterial size change (enlargement or contraction), independent or dependent of neointimal thickening.

TL;DR: Thrombolysis patency was preferable to angioplasty patency after thromboeltic therapy in acute myocardial infarction, but both were associated with the same low in-hospital and long-term mortality rates, suggesting that rescue angiopLasty is beneficial in some patients with failure of infarct-related artery recanalization after thROMbolytic therapy.