E
Eric J. Topol
Researcher at Scripps Health
Publications - 1406
Citations - 162373
Eric J. Topol is an academic researcher from Scripps Health. The author has contributed to research in topics: Myocardial infarction & Angioplasty. The author has an hindex of 193, co-authored 1373 publications receiving 151025 citations. Previous affiliations of Eric J. Topol include Loyola University Chicago & Cleveland Clinic.
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Long-term mortality of patients with acute myocardial infarction in the United States and Canada: comparison of patients enrolled in Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO)-I.
Padma Kaul,Paul W. Armstrong,Wei Ching Chang,C. David Naylor,Christopher B. Granger,Kerry L. Lee,Eric D. Peterson,Robert M. Califf,Eric J. Topol,Daniel B. Mark +9 more
TL;DR: The results suggest, for the first time, that the more conservative pattern of care with regard to early revascularization in Canada for ST-segment elevation acute myocardial infarction may have a detrimental effect on long-term survival.
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Extent of ST-segment depression and cardiac events in non-ST-segment elevation acute coronary syndromes.
Stefano Savonitto,Mauricio G. Cohen,Alessandro Politi,Michael P. Hudson,David F. Kong,Yao Huang,Karen S. Pieper,Francesco Mauri,Galen S. Wagner,Robert M. Califf,Eric J. Topol,Christopher B. Granger +11 more
TL;DR: In patients with NSTE ACS, the sum of ST-segment depression in all ECG leads is a powerful predictor of all-cause mortality at 30 days, independent of clinical variables and correlates with the extent and severity of coronary artery disease.
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Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb
Karen P. Alexander,Eric D. Peterson,Christopher B. Granger,A.Cecilia Casas,Frans Van de Werf,Paul W. Armstrong,Alan D. Guerci,Eric J. Topol,Robert M. Califf +8 more
TL;DR: There is significant room for improvement in the use of recommended drugs in patients with non-ST elevation acute coronary syndromes, and medication use that more closely follows recommendations could reduce mortality in this population.
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Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals
Vikas Bansal,Johann Gassenhuber,Tierney Phillips,Glenn Oliveira,Rebecca Harbaugh,Nikki Villarasa,Eric J. Topol,Thomas Seufferlein,Bernhard O. Boehm,Bernhard O. Boehm,Bernhard O. Boehm +10 more
TL;DR: The results confirm that MODY is under-diagnosed, particularly in individuals presenting with early onset diabetes and clinically labeled as type 2 diabetes; thus, sequencing of all monogenic diabetes genes should be routinely considered in such individuals.
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Reduction in Myocardial Infarct Size by Basic Fibroblast Growth Factor After Temporary Coronary Occlusion in a Canine Model
Mark C.G Horrigan,Andrew I. MacIsaac,Francesca A. Nicolini,D. G. Vince,Pauline Lee,Stephen G. Ellis,Eric J. Topol +6 more
TL;DR: The data suggest that bFGF mediates myocardial salvage independently of angiogenesis and that reperfusion after infarction may attenuate the stimulus for neovascularization.