E
Eric J. Topol
Researcher at Scripps Health
Publications - 1406
Citations - 162373
Eric J. Topol is an academic researcher from Scripps Health. The author has contributed to research in topics: Myocardial infarction & Angioplasty. The author has an hindex of 193, co-authored 1373 publications receiving 151025 citations. Previous affiliations of Eric J. Topol include Loyola University Chicago & Cleveland Clinic.
Papers
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Journal ArticleDOI
Administration of Recombinant P-Selectin Glycoprotein Ligand Fc Fusion Protein Suppresses Inflammation and Neointimal Formation in Zucker Diabetic Rat Model
Zhongmin Zhou,Marc S. Penn,Farhad Forudi,Xiaorong Zhou,Khaldoun G. Tarakji,Eric J. Topol,A. Michael Lincoff,Kai Wang +7 more
TL;DR: Reduction of P-selectin–mediated leukocyte activation with the use of recombinant P- selectin–soluble glycoprotein ligand-Ig decreases the inflammatory response and limits neointimal formation after balloon injury in diabetes.
Journal ArticleDOI
Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease
TL;DR: In this article, salient issues to facilitate research in coronary artery disease and acute myocardial infarction genotyping have been reviewed, in part owing to the difficulties in defining cases and controls.
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Molecular Autopsy for Sudden Death in the Young: Is Data Aggregation the Key?
Manuel Rueda,Jennifer L. Wagner,Tierney Phillips,Sarah E. Topol,Evan D. Muse,Evan D. Muse,Jonathan R. Lucas,Glenn N. Wagner,Eric J. Topol,Eric J. Topol,Ali Torkamani +10 more
TL;DR: Half of the cases clinically diagnosed as sudden infant death syndrome had an increased ratio of heteroplasmic variants, and that the variants were also present in the mothers, and it is believed that community-based data aggregation and sharing will eventually lead to an improved classification of variants.
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Minimizing the risk of inappropriately administering thrombolytic therapy (Thrombolysis and Angioplasty in Myocardial Infarction [TAMI] study group)
Gregory D. Chapman,E. Magnus Ohman,Eric J. Topol,Richard J. Candela,Dean J. Kereiakes,Joseph Samaha,Eric Berrios,Karen S. Pieper,Sharon Y. Young,Robert M. Califf +9 more
TL;DR: A simple algorithm with specific criteria was used for diagnosing acute myocardial infarction and administering thrombolytic therapy in several clinical settings, and led to a low rate of misdiagnosis.
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Effect of abciximab on the pattern of reperfusion in patients with acute myocardial infarction treated with primary angioplasty
Sorin J. Brener,Lawrence A Barr,Lawrence A Barr,J. E. B. Burchenal,J. E. B. Burchenal,Katherine E. Wolski,Katherine E. Wolski,Mark B. Effron,Eric J. Topol,Eric J. Topol +9 more
TL;DR: Abciximab significantly reduced the time-to-peak creatine kinase without affecting enzymatic infarct size, suggesting a beneficial effect on the pattern and speed of reperfusion.