F
Fergus Shanahan
Researcher at National University of Ireland
Publications - 727
Citations - 59181
Fergus Shanahan is an academic researcher from National University of Ireland. The author has contributed to research in topics: Inflammatory bowel disease & Gut flora. The author has an hindex of 117, co-authored 705 publications receiving 51963 citations. Previous affiliations of Fergus Shanahan include Imperial College London & Mater Misericordiae Hospital.
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Journal ArticleDOI
Clostridium difficile carriage in adult cystic fibrosis (CF); implications for patients with CF and the potential for transmission of nosocomial infection.
D.G. Burke,M.J. Harrison,C. Fleming,M. Mccarthy,C. Shortt,Imran Sulaiman,Desmond M. Murphy,Joseph A. Eustace,Fergus Shanahan,Colin Hill,Catherine Stanton,Mary C. Rea,R.P. Ross,Barry J. Plant +13 more
TL;DR: A high prevalence of hypervirulent, toxigenic strains of C. difficile is demonstrated in asymptomatic patients with CF, highlighting the potential role of asymPTomatic Patients with CF in nosocomial transmission of the bacillus.
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Differential regulation of Toll-like receptor signalling in spleen and Peyer's patch dendritic cells.
TL;DR: Differential regulation of TLR signalling was also evident in bacteria‐conditioned bone‐marrow‐derived cells indicating that bacterial signalling may be a mechanism for inducing altered gene regulation in PP DCs.
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Differential intestinal M-cell gene expression response to gut commensals.
TL;DR: It is demonstrated that M cells have the ability to discriminate between different commensal bacteria and modify subsequent immune responses and Translocation of bacteria and M‐cell gene expression responses were confirmed in murine M cells following bacterial challenge in vivo.
Journal ArticleDOI
Digestion of epithelial tight junction proteins by the commensal Clostridium perfringens
Mihaela Pruteanu,Fergus Shanahan +1 more
TL;DR: It is concluded that C. perfringens culture supernatant mediates digestion of epithelial cell junctional proteins, which is likely to enable access to the extracellular matrix components by the paracellular pathway.
Journal ArticleDOI
Enhanced peripheral blood T-cell cytotoxicity in inflammatory bowel disease.
Fergus Shanahan,Bernard Leman,Richard L. Deem,Adrene Niederlehner,Michael Brogan,Stephan R. Targan +5 more
TL;DR: Peripheral blood lymphocytes from patients with Crohn's disease exhibited significantly enhanced levels of anti-CD3-triggered T-cell cytotoxicity, providing indirect evidence for increased activity of a subpopulation of cytotoxic T cells in inflammatory bowel disease.