F
Fergus Shanahan
Researcher at National University of Ireland
Publications - 727
Citations - 59181
Fergus Shanahan is an academic researcher from National University of Ireland. The author has contributed to research in topics: Inflammatory bowel disease & Gut flora. The author has an hindex of 117, co-authored 705 publications receiving 51963 citations. Previous affiliations of Fergus Shanahan include Imperial College London & Mater Misericordiae Hospital.
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Journal ArticleDOI
Enteric neuropathophysiology and inflammatory bowel disease
TL;DR: In this issue of Neurogastroenterology and Motility, Geboes and Collins present an overview of the structural abnormalities of the enteric nervous system in Crohn's disease and ulcerative colitis.
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In vitro replication models for the hepatitis C virus.
P. Sheehy,B. Mullan,Isabelle Moreau,Elizabeth Kenny-Walsh,Fergus Shanahan,Martina F. Scallan,Liam J. Fanning +6 more
TL;DR: The aim of this study is to deal with developments in HCV replication models in a chronological order from the early 1990s to the recent infectious HCV cell culture systems.
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TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells.
Jerzy A. Woznicki,Nisha Saini,Peter Flood,Subhasree Rajaram,Ciaran M. Lee,Panagiota Stamou,Agnieszka Skowyra,Milan Bustamante-Garrido,Karine Regazzoni,Nyree Crawford,Simon S. McDade,Daniel B. Longley,Pedro Aza-Blanc,Fergus Shanahan,Syed Akbar Zulquernain,Jane McCarthy,Silvia Melgar,Bradford L McRae,Kenneth Nally +18 more
TL;DR: In this paper, the authors identified JAK1/2 kinases as the principal and nonredundant drivers of the synergistic killing of human IECs by IFN-γ/TNF-α.
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Fas ligand expressed in colon cancer is not associated with increased apoptosis of tumor cells in vivo
Aileen Houston,F Waldron-Lynch,Michael W. Bennett,Desmond Roche,Gerald C. O'Sullivan,Fergus Shanahan,Joe O'Connell +6 more
TL;DR: The results indicate that colon tumors are insensitive to FasL‐mediated apoptosis in vivo, since FasL expression in tumor nests correlated with diminished infiltration of tumor‐infiltrating lymphocytes (TILs).
Journal ArticleDOI
Fas ligand and Fas receptor are coexpressed in normal human esophageal epithelium: a potential mechanism of apoptotic epithelial turnover.
Michael W. Bennett,Joe O'Connell,Gerald C. O'Sullivan,D. Roche,C. Brady,John Kevin Collins,Fergus Shanahan +6 more
TL;DR: Co-localization of FasL mRNA and protein confirmed that FasL expression is induced in esophageal epithelial cells as they reach terminal differentiation, consistent with a contributory role for Fas-mediated autocrine suicide or paracrine fratricide in the apoptotic turnover of normal esophagal epithelium.