F
Fergus Shanahan
Researcher at National University of Ireland
Publications - 727
Citations - 59181
Fergus Shanahan is an academic researcher from National University of Ireland. The author has contributed to research in topics: Inflammatory bowel disease & Gut flora. The author has an hindex of 117, co-authored 705 publications receiving 51963 citations. Previous affiliations of Fergus Shanahan include Imperial College London & Mater Misericordiae Hospital.
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Journal ArticleDOI
Bacterial DNA within granulomas of patients with Crohn's disease--detection by laser capture microdissection and PCR.
Paul Ryan,Raymond Kelly,Garry Lee,J. Kevin Collins,Gerald C. O'Sullivan,Joe O'Connell,Fergus Shanahan +6 more
TL;DR: E. coli DNA may be detected more frequently in Crohn'sgranulomas than in other non-Crohn's bowel granulomas, which may indicate a tendency for lumenal bacteria to colonize inflamed tissue, or may be due to increased uptake of bacterial DNA by gut antigen presenting cells.
Journal ArticleDOI
Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues
Rebecca Wall,R. Paul Ross,Fergus Shanahan,Liam O'Mahony,Caitlin O'Mahony,M. Coakley,Orla M. Hart,Peadar G. Lawlor,Eamonn Martin Quigley,Barry Kiely,Gerald F. Fitzgerald,Catherine Stanton +11 more
TL;DR: These results are consistent with the concept that the metabolome is a composite of host and microbe metabolic activity and that the influence of the microbiota on host fatty acid composition can be manipulated by oral administration of CLA-producing microorganisms.
Journal ArticleDOI
Basic aspects and pharmacology of probiotics: an overview of pharmacokinetics, mechanisms of action and side-effects.
Philippe Marteau,Fergus Shanahan +1 more
TL;DR: Although the safety of commercial probiotics is excellent, this aspect of the pharmacology should be studied in more detail, especially in immunocompromised hosts.
Journal Article
Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis.
B. Mulcahy,F. Waldron-Lynch,Michael F. McDermott,Claire Adams,Christopher I. Amos,D. K. Zhu,Ryk Ward,Daniel O. Clegg,Fergus Shanahan,Michael G. Molloy,Fergal O'Gara +10 more
TL;DR: The TNF-LT region appears to influence susceptibility to RA, distinct from HLA-DR, and was investigated as a possible susceptibility locus for rheumatoid arthritis.
Journal ArticleDOI
Human methanogen diversity and incidence in healthy and diseased colonic groups using mcrA gene analysis.
TL;DR: The mcrA gene serves as a useful biomarker for meethanogen detection in the human gut and the varying trends of methanogen incidence in thehuman gut could serve as important indicators of intestinal function.