F
Fergus Shanahan
Researcher at National University of Ireland
Publications - 727
Citations - 59181
Fergus Shanahan is an academic researcher from National University of Ireland. The author has contributed to research in topics: Inflammatory bowel disease & Gut flora. The author has an hindex of 117, co-authored 705 publications receiving 51963 citations. Previous affiliations of Fergus Shanahan include Imperial College London & Mater Misericordiae Hospital.
Papers
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Journal ArticleDOI
Interactions between Medications and the Gut Microbiome in Inflammatory Bowel Disease
TL;DR: While treatments accounted for a relatively small proportion of the geographic contribution to microbiome variance between Irish and Canadian participants, additive effects from multiple medications contributed significantly to microbiome differences between UC and CD.
Journal ArticleDOI
1058 Tryptophan Catabolism in Irritable Bowel Syndrome: Relationship to Cytokines, Severity and Psychiatric Co-Morbidity
Peter Fitzgerald,Gerard Clarke,Paul Scully,John F. Cryan,Fergus Shanahan,Eamonn Martin Quigley,Eugene M Cassidy,Timothy G. Dinan +7 more
TL;DR: The results indicate an increased sensitivity to IFN-γ in the regulation of tryptophan catabolism in IBS, which may predispose to the increased rate of Kyn production observed in severe IBS cases and to the high co-morbidity with depressive and anxiety disorders in this group.
Patent
Use of salivary lactobacillus
TL;DR: A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans as discussed by the authors, which is useful in the prophylaxis and/or treatment of undesirable inflammatory activity.
Journal ArticleDOI
Non-linkage of a T-Cell Receptor γ Chain Microsatellite (D7S485) to Rheumatoid Arthritis in Multiplex Families
Michael F. McDermott,Christine Hsu,Michael G. Molloy,B. Mulcahy,M Phelan,Fergus Shanahan,Fergal O'Gara,Claire Adams,Laurence A. Rubin,Daniel O. Clegg,Dee Husebye,Christopher I. Amos,Ryk Ward,Danie lL. Kastner +13 more
TL;DR: There was no evidence for segregation of TCRG genes with RA in affected siblings and significantly negative lod scores were obtained from linkage analyses using both autosomal dominant and recessive models of inheritance.
Journal ArticleDOI
The nonindustrialised microbiome in a modern world.
TL;DR: In this paper , the authors explore the underlying mechanisms of the differences between industrialised and non-industrialised populations and explore the potential benefits of nonindustrialised microbiome in a modern world, particularly in view of contrasting epidemiological risks of acquiring chronic inflammatory and metabolic disorders.