F
Fergus Shanahan
Researcher at National University of Ireland
Publications - 727
Citations - 59181
Fergus Shanahan is an academic researcher from National University of Ireland. The author has contributed to research in topics: Inflammatory bowel disease & Gut flora. The author has an hindex of 117, co-authored 705 publications receiving 51963 citations. Previous affiliations of Fergus Shanahan include Imperial College London & Mater Misericordiae Hospital.
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Journal ArticleDOI
The gut microbiota—a clinical perspective on lessons learned
TL;DR: The microbiota is both a target for drug therapy and a repository for drug discovery, and its secrets promise the realization of personalized medicine and nutrition, and will change and improve conventional dietary management.
Journal ArticleDOI
Bacterial bile salt hydrolase in host metabolism: Potential for influencing gastrointestinal microbe-host crosstalk
TL;DR: It is demonstrated that gastrointestinal expression of BSH results in local bile acid deconjugation with concomitant alterations in lipid and cholesterol metabolism, signaling functions and weight gain.
Journal ArticleDOI
IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.
Shane E. Russell,Rachel M. Horan,Rachel M. Horan,Anna M. Stefanska,Anna M. Stefanska,Alyssa Carey,Gemma Leon,Gemma Leon,M Aguilera,D Statovci,Tara Moran,Tara Moran,Padraic G. Fallon,Padraic G. Fallon,Fergus Shanahan,Elizabeth Brint,Silvia Melgar,Seamus Hussey,Seamus Hussey,Patrick T. Walsh,Patrick T. Walsh +20 more
TL;DR: It is demonstrated that expression levels of IL-36α are specifically elevated in the colonic mucosa of ulcerative colitis patients, and it is indicated that the IL- 36R pathway may represent a novel target for therapeutic intervention in IBD.
Journal ArticleDOI
Seasonality of vitamin D status and bone turnover in patients with Crohn's disease.
D. McCarthy,Paula Duggan,M. O’Brien,Mairead Kiely,Jane McCarthy,Fergus Shanahan,Kevin D. Cashman +6 more
TL;DR: This study highlights the importance of knowing vitamin D status during summertime and whether a seasonal variation exists in bone turnover in patients with Crohn's disease.
Journal ArticleDOI
Gut microbiota alterations associated with reduced bone mineral density in older adults.
Mrinmoy Das,Owen Cronin,Owen Cronin,David Keohane,Edel M Cormac,Helena Nugent,Michelle Nugent,Catherine B Molloy,Paul W. O'Toole,Fergus Shanahan,Michael G. Molloy,Ian B. Jeffery +11 more
TL;DR: Reduced BMD in osteopenia and osteoporosis is associated with an altered microbiota, which may be useful as biomarkers or therapeutic targets in individuals at high risk of reductions in BMD.