F
Fergus Shanahan
Researcher at National University of Ireland
Publications - 727
Citations - 59181
Fergus Shanahan is an academic researcher from National University of Ireland. The author has contributed to research in topics: Inflammatory bowel disease & Gut flora. The author has an hindex of 117, co-authored 705 publications receiving 51963 citations. Previous affiliations of Fergus Shanahan include Imperial College London & Mater Misericordiae Hospital.
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Journal ArticleDOI
Correlation of probiotic Lactobacillus salivarius growth phase with its cell wall-associated proteome
Peter Kelly,Patricia B. Maguire,Mary Bennett,Desmond J. Fitzgerald,Richard Edwards,Bernd Thiede,Achim Treumann,J. Kevin Collins,Gerald C. O'Sullivan,Fergus Shanahan,Colum P. Dunne +10 more
TL;DR: Data suggest that at least some of the beneficial attributes of probiotic lactobacilli, and in particular this strain, may be due to nonpathogenic mimicry of pathogens and potentially be mediated through a form of attenuated virulence.
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Mast cell heterogeneity.
TL;DR: The development of techniques to purify isolated mast cell subpopulations will facilitate future analysis of the biochemical basis of the functional heterogeneity of mast cells, since mucosal mast cells differ from connective tissue mast cells in their response to a variety of physiologically occurring regulatory peptides.
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Fas ligand mediates immune privilege and not inflammation in human colon cancer, irrespective of TGF-β expression
TL;DR: Results suggest that tumour-expressed FasL is inhibitory rather than stimulatory towards antitumour immune responses, and whether TGF-β1 regulates FasL function.
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Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model.
Siobhain M. O'Mahony,A. S B Chua,Eamonn Martin Quigley,Gerard Clarke,Fergus Shanahan,P. W. N. Keeling,Timothy G. Dinan +6 more
TL;DR: Altered central serotonin responses are found in both IBS and in an animal model, and an increased turnover of 5HT was found in the brainstem together with a trend toward increased activity of the SERT gene.
Journal ArticleDOI
Micrometastases in bone marrow of patients undergoing “curative” surgery for gastrointestinal cancer
Gerald C. O'Sullivan,J. Kevin Collins,Fiona O'Brien,Bernie Crowley,Karen Murphy,Gary Lee,Fergus Shanahan +6 more
TL;DR: Flow cytometric assessment of bone marrow is a reliable, objective, and quantitative method of detecting micrometastatic deposits found in a substantial subset of patients undergoing surgery for gastrointestinal adenocarcinomas.