F
Fergus Shanahan
Researcher at National University of Ireland
Publications - 727
Citations - 59181
Fergus Shanahan is an academic researcher from National University of Ireland. The author has contributed to research in topics: Inflammatory bowel disease & Gut flora. The author has an hindex of 117, co-authored 705 publications receiving 51963 citations. Previous affiliations of Fergus Shanahan include Imperial College London & Mater Misericordiae Hospital.
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Journal ArticleDOI
Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection
Jillian R.M. Brown,Burkhardt Flemer,Susan A. Joyce,Akbar Zulquernain,Donal Sheehan,Fergus Shanahan,Paul W. O'Toole +6 more
TL;DR: A consistent metabolic signature was identified in the post-transplant microbiota, with reduced primary bile acids and substantial restoration of secondary bile acid production capacity, in C. difficile infection.
Journal ArticleDOI
Anti-Neutrophil Cytoplasmic Antibodies in Ulcerative Colitis
Richard H. Duerr,Richard H. Duerr,Stephan R. Targan,Stephan R. Targan,Carol J. Landers,Carol J. Landers,Lloyd R. Sutherland,Lloyd R. Sutherland,Fergus Shanahan,Fergus Shanahan +9 more
TL;DR: In this paper, the specificity of anti-neutrophil cytoplasmic antibodies for ulcerative colitis as compared with other colitides and diarrheal illnesses was determined.
Journal ArticleDOI
The fas counterattack : a molecular mechanism of tumor immune privilege
TL;DR: A 'Fas counterattack" mechanism of immune escape has emerged in colon, melanoma, and liver cancer cells, which are Fas-resistant but express FasL, where it mediates immune privilege by inducing apoptosis in infiltrating proinflammatory immunocytes.
Journal ArticleDOI
Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis.
Joe O'Connell,Michael W. Bennett,Kenneth Nally,Gerald C. O'Sullivan,John Kevin Collins,Fergus Shanahan +5 more
TL;DR: Results indicate that IFN‐γ increases the sensitivity of colonic epithelial cells to diverse apoptotic stimuli in concert, via upregulation of caspase‐1.
Journal ArticleDOI
Host-flora interactions in inflammatory bowel disease.
TL;DR: An overview of host-flora interactions in inflammatory bowel disease, in which there is increasing acceptance of the importance of gene–environment interactions, and particularly host–flora dialogue in the gut.