F
Fergus Shanahan
Researcher at National University of Ireland
Publications - 727
Citations - 59181
Fergus Shanahan is an academic researcher from National University of Ireland. The author has contributed to research in topics: Inflammatory bowel disease & Gut flora. The author has an hindex of 117, co-authored 705 publications receiving 51963 citations. Previous affiliations of Fergus Shanahan include Imperial College London & Mater Misericordiae Hospital.
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Journal ArticleDOI
Mechanisms of Adherence of a Probiotic Lactobacillus Strain during and after in vivo Assessment in Ulcerative Colitis Patients
Colum P. Dunne,Peter Kelly,Sile O'Halloran,Declan Soden,Mary Bennett,Terttu Vilpponen-Salmela,Barry Kiely,Liam O'Mahony,J. Kevin Collins,Gerald C. O'Sullivan,Fergus Shanahan +10 more
TL;DR: It is found that the bacteria adhered at higher levels to differentiated rather than undifferentiated epithelial monolayers; and that stationary phase lactobacilli were found to adhere to eukaryotic HT-29 and Caco-2 epithelial cells at greater levels than log phase bacterial cells.
Journal ArticleDOI
Concomitant Exposure to Ovalbumin and Endotoxin Augments Airway Inflammation but Not Airway Hyperresponsiveness in a Murine Model of Asthma
John Mac Sharry,Karim H. Shalaby,Cinzia L. Marchica,Soroor Farahnak,Tien Chieh-Li,Susan Lapthorne,Salman T. Qureshi,Fergus Shanahan,James G. Martin +8 more
TL;DR: Contaminating LPS is not required for induction of airway hyperresponsiveness but amplifies the Th2 inflammatory response and is a critical mediator of the neutrophil, Th1 and T regulatory cell responses to OVA.
Journal ArticleDOI
Probiotic bacteria and pathogenic bacteria ellicit differential cytokine responses from dendrictic cells
Liam O'Mahony,Y. Zong,Samin K. Sharma,Richard Aranda,Gerald C. O'Sullivan,John Kevin Collins,Fergus Shanahan +6 more
Journal ArticleDOI
The sphingosine-1-phosphate analogue FTY720 impairs mucosal immunity and clearance of the enteric pathogen Citrobacter rodentium.
Carola T. Murphy,Lindsay J. Hall,Grainne Hurley,Aoife Quinlan,John MacSharry,Fergus Shanahan,Kenneth Nally,Silvia Melgar +7 more
TL;DR: Gene expression analysis demonstrated that FTY720-treated infected mice had an impaired innate immune response and a blunted mucosal adaptive immune response, including Th1 cytokines, as well as significantly lower numbers of colonic dendritic cells, macrophages, and T cells.