F
Florian Gothe
Researcher at Ludwig Maximilian University of Munich
Publications - 31
Citations - 817
Florian Gothe is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 18 publications receiving 309 citations. Previous affiliations of Florian Gothe include Boston Children's Hospital & Newcastle University.
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Journal ArticleDOI
Single-cell multi-omics analysis of the immune response in COVID-19.
Emily Stephenson,Gary Reynolds,Rachel A. Botting,Fernando J Calero-Nieto,Michael D Morgan,Michael D Morgan,Zewen K. Tuong,Zewen K. Tuong,Karsten Bach,Karsten Bach,Waradon Sungnak,Kaylee B Worlock,Masahiro Yoshida,Natsuhiko Kumasaka,Katarzyna D. Kania,Justin Engelbert,Bayanne Olabi,Jarmila Stremenova Spegarova,Nicola K. Wilson,Nicole Mende,Laura Jardine,Louis C.S. Gardner,Issac Goh,Dave Horsfall,Jim McGrath,Simone Webb,Michael W. Mather,Rik G.H. Lindeboom,Emma Dann,Ni Huang,Krzysztof Polanski,Elena Prigmore,Florian Gothe,Florian Gothe,Jonathan M. Scott,Rebecca Payne,Kenneth F Baker,Kenneth F Baker,Aidan T Hanrath,Aidan T Hanrath,Ina Schim van der Loeff,Andrew Barr,Amada Sanchez-Gonzalez,Laura Bergamaschi,Federica Mescia,Josephine Barnes,Eliz Kilich,Angus de Wilton,A Saigal,Aarash Saleh,Sam M. Janes,Sam M. Janes,Claire Smith,Nusayhah Gopee,Caroline Wilson,Caroline Wilson,Paul Coupland,Jonathan Coxhead +57 more
TL;DR: In this article, the authors performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19.
Journal ArticleDOI
Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency.
Romain Lévy,Romain Lévy,Romain Lévy,Satoshi Okada,Satoshi Okada,Vivien Béziat,Vivien Béziat,Kunihiko Moriya,Kunihiko Moriya,Caini Liu,Louis Yi Ann Chai,Louis Yi Ann Chai,Mélanie Migaud,Mélanie Migaud,Fabian Hauck,Amein Al Ali,Cyril Cyrus,Chittibabu Vatte,Turkan Patiroglu,Ekrem Unal,Marie Ferneiny,Nobuyuki Hyakuna,Serdar Nepesov,Matías Oleastro,Aydan Ikinciogullari,Figen Dogu,Takaki Asano,Osamu Ohara,Ling Yun,Ling Yun,Erika Della Mina,Erika Della Mina,Didier Bronnimann,Didier Bronnimann,Yuval Itan,Florian Gothe,Jacinta Bustamante,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Natalia Tahuil,Caner Aytekin,Aicha Salhi,Saleh Al Muhsen,Masao Kobayashi,Julie Toubiana,Laurent Abel,Laurent Abel,Laurent Abel,Xiaoxia Li,Yildiz Camcioglu,Fatih Celmeli,Christoph Klein,Suzan A AlKhater,Jean-Laurent Casanova,Anne Puel,Anne Puel,Anne Puel +57 more
TL;DR: Twenty-one patients from 12 unrelated kindreds, homozygous for 12 different mutant alleles that underlie AR IL-17RA deficiency are reported, including this first patient.
Journal ArticleDOI
Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2.
Christopher J A Duncan,Christopher J A Duncan,Benjamin J. Thompson,Rui Chen,Gillian I. Rice,Florian Gothe,Florian Gothe,Dan F. Young,Simon C. Lovell,Victoria G. Shuttleworth,Vicky Brocklebank,Bronte M. Corner,Andrew J. Skelton,Vincent Bondet,Jonathan Coxhead,Darragh Duffy,Cécile Fourrage,John H. Livingston,Julija Pavaine,Julija Pavaine,Edmund Cheesman,Stephania Bitetti,Angela Grainger,Meghan Acres,Barbara A. Innes,Aneta Mikulasova,Ruyue Sun,Rafiqul Hussain,Ronnie Wright,Ronnie Wright,Robert Wynn,Mohammed Zarhrate,Leo A. H. Zeef,Katrina M Wood,Stephen M. Hughes,Claire L. Harris,Karin R. Engelhardt,Yanick J. Crow,Yanick J. Crow,Richard E. Randall,David J. Kavanagh,David J. Kavanagh,Sophie Hambleton,Sophie Hambleton,Tracy A Briggs,Tracy A Briggs +45 more
TL;DR: Observations reveal an essential in vivo function of STAT2 in the regulation of human IFNα/β signaling, providing concrete evidence of the serious pathological consequences of unrestrained IFN α/β activity and supporting efforts to target this pathway therapeutically in IFN-associated disease.
Journal ArticleDOI
The expansion of human T-bet high CD21 low B cells is T cell dependent
Baerbel Keller,Valentina Strohmeier,Valentina Strohmeier,Ina Harder,Susanne Unger,Kathryn Payne,Geoffroy Andrieux,Geoffroy Andrieux,Melanie Boerries,Melanie Boerries,Peter Tobias Felixberger,Jonathan J. M. Landry,Alexandra Nieters,Anne Rensing-Ehl,Ulrich Salzer,Natalie Frede,Susanne Usadel,Roland Elling,Carsten Speckmann,Ina Hainmann,Elizabeth Ralph,Kimberly Gilmour,Marjolein Wentink,Mirjam van der Burg,Hye Sun Kuehn,Sergio D. Rosenzweig,Uwe Kölsch,Horst von Bernuth,Petra Kaiser-Labusch,Florian Gothe,Florian Gothe,Sophie Hambleton,Sophie Hambleton,Alexandru Vlagea,Ana Garcia Garcia,Ana Garcia Garcia,Laia Alsina,Gašper Markelj,Tadej Avcin,Julia Vasconcelos,Margarida Guedes,Jing-Ya Ding,Cheng-Lung Ku,Cheng-Lung Ku,Bella Shadur,Bella Shadur,Bella Shadur,Danielle T. Avery,Nils Venhoff,Jens Thiel,Heiko Becker,Lucía Victoria Erazo-Borrás,Claudia M. Trujillo-Vargas,José Luis Franco,Claire Fieschi,Satoshi Okada,Paul Gray,Gulbu Uzel,Jean-Laurent Casanova,Manfred Fliegauf,Bodo Grimbacher,Hermann Eibel,Stephan Ehl,Reinhard E. Voll,Marta Rizzi,Polina Stepensky,Vladimir Benes,Cindy S. Ma,Cindy S. Ma,Claudia Bossen,Stuart G. Tangye,Stuart G. Tangye,Klaus Warnatz +72 more
TL;DR: In this article, the authors show that the accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic activation of the adaptive immune system in certain infections and autoimmune disorders.
Journal ArticleDOI
Categorizing diffuse parenchymal lung disease in children
Matthias Griese,A. Irnstetter,Meike Hengst,Helen Burmester,Felicitas Nagel,Jan Ripper,Maria Feilcke,Ingo Pawlita,Florian Gothe,Matthias Kappler,Andrea Schams,Traudl Wesselak,Daniela Rauch,Thomas Wittmann,Peter Lohse,Frank Brasch,Carolin Kröner +16 more
TL;DR: This study provides a suitable workflow and hand-on rules for the categorization of pediatric DPLD and potential pitfalls were identified and a foundation was laid for the development of consensus-based, international categorization guidelines.