S
Si Lok
Researcher at University of Hong Kong
Publications - 30
Citations - 2942
Si Lok is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Genome & Transcriptome. The author has an hindex of 21, co-authored 30 publications receiving 2624 citations. Previous affiliations of Si Lok include The Centre for Applied Genomics & The Chinese University of Hong Kong.
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Journal ArticleDOI
Increased exonic de novo mutation rate in individuals with schizophrenia
Simon Girard,Julie Gauthier,Anne Noreau,Lan Xiong,Sirui Zhou,Loubna Jouan,Alexandre Dionne-Laporte,Dan Spiegelman,Edouard Henrion,Ousmane Diallo,Pascale Thibodeau,Isabelle Bachand,Jessie Y.J. Bao,Amy Hin Yan Tong,Chi-Ho Lin,Bruno Millet,Bruno Millet,Nematollah Jaafari,Nematollah Jaafari,Ridha Joober,Patrick A. Dion,Si Lok,Marie-Odile Krebs,Guy A. Rouleau,Guy A. Rouleau +24 more
TL;DR: This study sequenced the exomes of 14 schizophrenia probands and their parents to identify 15 de novo mutations (DNMs) in eight probands, which is significantly more than expected considering the previously reported DNM rate.
Journal ArticleDOI
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma
Leilei Chen,Yan Li,Chi Ho Lin,Tim Chan,Tim Chan,Raymond Kwok Kei Chow,Yangyang Song,Ming Liu,Yunfei Yuan,Li Fu,Kar Lok Kong,Lihua Qi,Na Zhang,Amy Hin Yan Tong,Dora L.W. Kwong,Kwan Man,Chung Mau Lo,Si Lok,Daniel G. Tenen,Xin Yuan Guan,Xin Yuan Guan +20 more
TL;DR: This article showed that adenosine-to-inosine (A→I) RNA editing of AZIN1 (encoding antizyme inhibitor 1) is increased in hepatocellular carcinoma (HCC) specimens.
Journal ArticleDOI
Analysis of the bacterial community in a laboratory-scale nitrification reactor and a wastewater treatment plant by 454-pyrosequencing
TL;DR: It was found that the commonly used informatics tool "RDP classifier" may drastically assign Nitrosomonas sequences into a wrong taxonomic unit resulting in underestimation of ammonia-oxidizing bacteria in the bioreactors.
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Chromosomal-level assembly of the Asian seabass genome using long sequence reads and multi-layered scaffolding
Shubha Vij,Heiner Kuhl,Inna S. Kuznetsova,Inna S. Kuznetsova,Aleksey Komissarov,Andrey A. Yurchenko,Peter van Heusden,Siddharth Singh,Natascha May Thevasagayam,Sai Rama Sridatta Prakki,Kathiresan Purushothaman,Jolly M. Saju,Junhui Jiang,Stanley Kimbung Mbandi,Mario Jonas,Amy Hin Yan Tong,Sarah Mwangi,Doreen Lau,Si Yan Ngoh,Woei Chang Liew,Xueyan Shen,Lawrence S. Hon,James P Drake,Matthew Boitano,Richard Hall,Chen-Shan Chin,Ramkumar Lachumanan,Jonas Korlach,Vladimir A. Trifonov,Marsel R. Kabilov,Alexey E. Tupikin,Darrell Green,Simon Moxon,Tyler Garvin,Fritz J. Sedlazeck,Fritz J. Sedlazeck,Gregory Vurture,Gopikrishna Gopalapillai,Vinaya Kumar Katneni,Tansyn Noble,Vinod Scaria,Sridhar Sivasubbu,Dean R. Jerry,Stephen J. O'Brien,Stephen J. O'Brien,Michael C. Schatz,Michael C. Schatz,Tamas Dalmay,Stephen Turner,Si Lok,Alan Christoffels,László Orbán,László Orbán,László Orbán +53 more
TL;DR: The quality of the Asian seabass genome assembly far exceeds that of any other fish species, and will serve as a new standard for fish genomics.
Journal ArticleDOI
Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation
Shaoke Lou,Heung Man Lee,Hao Qin,Jing-Woei Li,Zhibo Gao,Xin Liu,Landon L Chan,Vincent Kl Lam,Wing-Yee So,Ying Wang,Si Lok,Jun Wang,Ronald Cw Ma,Stephen Kwok-Wing Tsui,Juliana C.N. Chan,Ting-Fung Chan,Kevin Y. Yip +16 more
TL;DR: An integrated analysis of whole-genome bisulfite sequencing and RNA sequencing data from human samples and cell lines finds that while promoter methylation inversely correlates with gene expression as generally observed, the repressive effect is clear only on genes with a very high DNA methylation level.