Hanna K. Isotalus

TL;DR: In response to recommendations to redefine statistical significance to P ≤ 0.005, it is proposed that researchers should transparently report and justify all choices they make when designing a study, including the alpha level.

TL;DR: It is suggested that the deficit of maintenance capacity and manipulation accuracy in PD patients is not primarily a dopaminergic one and supports a potential “overdosing” of intact manipulation mechanisms in healthy older adults by levodopa.

TL;DR: T2 heterogeneity can identify subtle changes in microstructural integrity of brain tissue in MCI and predict cognitive decline over a year, and a new model is described that considers the competing effects of factors that both increase and decrease T2.

TL;DR: It is found that levodopa did not affect the overall accuracy of choices, nor the relative expression of positively or negatively reinforced values, which contradicts several studies and suggests that overall dopamine levels may not play a role in the choice performance for values learned through reinforcement learning in older adults.

TL;DR: A non-dopaminergic deficit of maintenance capacity and manipulation accuracy in PD patients, and a potential “overdosing” of intact manipulation mechanisms in healthy older adults by levodopa are suggested.