W
William R. Scott
Researcher at Imperial College London
Publications - 11
Citations - 2002
William R. Scott is an academic researcher from Imperial College London. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 10, co-authored 11 publications receiving 1577 citations. Previous affiliations of William R. Scott include University College London & National Institutes of Health.
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Journal ArticleDOI
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
Simone Wahl,Alexander W. Drong,Benjamin Lehne,Marie Loh,Marie Loh,Marie Loh,William R. Scott,William R. Scott,Sonja Kunze,Pei-Chien Tsai,Janina S. Ried,Weihua Zhang,Weihua Zhang,Youwen Yang,Sili Tan,Giovanni Fiorito,Lude Franke,Simonetta Guarrera,Silva Kasela,Jennifer Kriebel,Rebecca C Richmond,Marco Adamo,Uzma Afzal,Uzma Afzal,Mika Ala-Korpela,Mika Ala-Korpela,Mika Ala-Korpela,Benedetta Albetti,Ole Ammerpohl,Jane F. Apperley,Marian Beekman,Pier Alberto Bertazzi,S. Lucas Black,Christine Blancher,Marc Jan Bonder,Mario Brosch,Maren Carstensen-Kirberg,Anton J. M. de Craen,Simon de Lusignan,Abbas Dehghan,Mohamed Elkalaawy,Krista Fischer,Oscar H. Franco,Tom R. Gaunt,Jochen Hampe,Majid Hashemi,Aaron Isaacs,Andrew Jenkinson,Sujeet Jha,Norihiro Kato,Vittorio Krogh,Michael Laffan,Christa Meisinger,Thomas Meitinger,Zuan Yu Mok,Valeria Motta,Hong Kiat Ng,Zacharoula Nikolakopoulou,Georgios Nteliopoulos,Salvatore Panico,Natalia Pervjakova,Holger Prokisch,Wolfgang Rathmann,Michael Roden,Federica Rota,Michelle Ann Rozario,Johanna K. Sandling,Johanna K. Sandling,Clemens Schafmayer,Katharina Schramm,Reiner Siebert,Reiner Siebert,P. Eline Slagboom,Pasi Soininen,Pasi Soininen,Lisette Stolk,Konstantin Strauch,E-Shyong Tai,Letizia Tarantini,Barbara Thorand,Ettje F. Tigchelaar,Rosario Tumino,André G. Uitterlinden,Cornelia M. van Duijn,Joyce B. J. van Meurs,Paolo Vineis,Ananda R. Wickremasinghe,Cisca Wijmenga,Tsun-Po Yang,Wei Yuan,Wei Yuan,Alexandra Zhernakova,Rachel L. Batterham,George Davey Smith,Panos Deloukas,Panos Deloukas,Panos Deloukas,Bastiaan T. Heijmans,Christian Herder,Albert Hofman,Cecilia M. Lindgren,Cecilia M. Lindgren,Lili Milani,Pim van der Harst,Annette Peters,Thomas Illig,Caroline L Relton,Melanie Waldenberger,Marjo-Riitta Järvelin,Valentina Bollati,Richie Soong,Tim D. Spector,James Scott,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Paul Elliott,Paul Elliott,Jordana T. Bell,Giuseppe Matullo,Christian Gieger,Jaspal S. Kooner,Harald Grallert,John C. Chambers +123 more
TL;DR: In this article, the authors used epigenome-wide association to show that body mass index (BMI), a key measure of adiposity, is associated with widespread changes in DNA methylation.
Journal ArticleDOI
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study.
John C. Chambers,Marie Loh,Marie Loh,Marie Loh,Benjamin Lehne,Alexander W. Drong,Jennifer Kriebel,Valeria Motta,Simone Wahl,Hannah R Elliott,Hannah R Elliott,Federica Rota,William R. Scott,William R. Scott,Weihua Zhang,Weihua Zhang,Sian-Tsung Tan,Sian-Tsung Tan,Gianluca Campanella,Marc Chadeau-Hyam,Loic Yengo,Loic Yengo,Rebecca C Richmond,Martyna Adamowicz-Brice,Uzma Afzal,Uzma Afzal,Kiymet Bozaoglu,Zuan Yu Mok,Hong Kiat Ng,François Pattou,François Pattou,Holger Prokisch,Michelle Ann Rozario,Letizia Tarantini,James Abbott,Mika Ala-Korpela,Benedetta Albetti,Ole Ammerpohl,Pier Alberto Bertazzi,Christine Blancher,R. Caiazzo,R. Caiazzo,John Danesh,Tom R. Gaunt,Simon de Lusignan,Christian Gieger,Thomas Illig,Sujeet Jha,Simon Jones,Jeremy B. M. Jowett,Antti J. Kangas,Anuradhani Kasturiratne,Norihiro Kato,Navaratnam Kotea,Sudhir Kowlessur,Janne Pitkäniemi,Prakash P Punjabi,Danish Saleheen,Danish Saleheen,Clemens Schafmayer,Pasi Soininen,Pasi Soininen,E-Shyong Tai,Barbara Thorand,Jaakko Tuomilehto,Ananda R. Wickremasinghe,Soterios A. Kyrtopoulos,Timothy J. Aitman,Christian Herder,Jochen Hampe,Stéphane Cauchi,Stéphane Cauchi,Caroline L Relton,Philippe Froguel,Richie Soong,Paolo Vineis,Marjo-Riitta Järvelin,James Scott,Harald Grallert,Valentina Bollati,Paul Elliott,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Jaspal S. Kooner +84 more
TL;DR: A nested case-control study of DNA methylation in Indian Asians and Europeans with incident type 2 diabetes who were identified from the 8-year follow-up of 25 372 participants in the London Life Sciences Prospective Population study.
Journal ArticleDOI
A link between FTO, ghrelin, and impaired brain food-cue responsivity
Efthimia Karra,Owen O'Daly,Agharul I. Choudhury,Ahmed Yousseif,Steven Millership,Marianne T. Neary,William R. Scott,Keval Chandarana,Sean Manning,Martin E. Hess,Hiroshi Iwakura,Takashi Akamizu,Queensta Millet,Cigdem Gelegen,Megan E. Drew,Sofia Rahman,Julian J. Emmanuel,Steven Williams,Ulrich Rüther,Jens C. Brüning,Dominic J. Withers,Fernando Zelaya,Rachel L. Batterham +22 more
TL;DR: Functional MRI in normal-weight AA and TT humans found that the FTO genotype modulates the neural responses to food images in homeostatic and brain reward regions, and shows that FTO regulates ghrelin, a key mediator of ingestive behavior.
Journal ArticleDOI
A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome-wide association studies
Benjamin Lehne,Alexander W. Drong,Marie Loh,Marie Loh,Weihua Zhang,Weihua Zhang,William R. Scott,William R. Scott,Sian-Tsung Tan,Sian-Tsung Tan,Uzma Afzal,Uzma Afzal,James Scott,Marjo-Riitta Järvelin,Paul Elliott,Mark I. McCarthy,Mark I. McCarthy,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,John C. Chambers,John C. Chambers,John C. Chambers +22 more
TL;DR: A comprehensive analysis pipeline for epigenome-wide association studies (EWAS) using the Illumina Infinium HumanMethylation450 BeadChip is developed, enabling accurate identification of methylation quantitative trait loci for hypothesis driven follow-up experiments.
Journal ArticleDOI
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Yun J. Sung,Thomas W. Winkler,Lisa de las Fuentes,Amy R. Bentley,Michael R. Brown,Aldi T. Kraja,Karen Schwander,Ioanna Ntalla,Xiuqing Guo,Nora Franceschini,Yingchang Lu,Ching-Yu Cheng,Xueling Sim,Dina Vojinovic,Jonathan Marten,Solomon K. Musani,Changwei Li,Mary F. Feitosa,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Melissa A. Richard,Raymond Noordam,Stella Aslibekyan,Hugues Aschard,Hugues Aschard,Traci M. Bartz,Rajkumar Dorajoo,Yongmei Liu,Alisa K. Manning,Alisa K. Manning,Tuomo Rankinen,Albert V. Smith,Salman M. Tajuddin,Bamidele O. Tayo,Helen R. Warren,Wei Zhao,Yanhua Zhou,Nana Matoba,Tamar Sofer,Maris Alver,Marzyeh Amini,Mathilde Boissel,Jin-Fang Chai,Xu Chen,Jasmin Divers,Ilaria Gandin,Chuan Gao,Franco Giulianini,Anuj Goel,Sarah E. Harris,Fernando Pires Hartwig,Andrea R. V. R. Horimoto,Fang-Chi Hsu,Anne U. Jackson,Mika Kähönen,Anuradhani Kasturiratne,Brigitte Kühnel,Karin Leander,Wen-Jane Lee,Keng-Hung Lin,Jian'an Luan,Colin A. McKenzie,He Meian,Christopher P. Nelson,Christopher P. Nelson,Rainer Rauramaa,Nicole Schupf,Robert A. Scott,Wayne Huey-Herng Sheu,Alena Stančáková,Fumihiko Takeuchi,Peter J. van der Most,Tibor V. Varga,Heming Wang,Yajuan Wang,Erin B. Ware,Stefan Weiss,Wanqing Wen,Lisa R. Yanek,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Saima Afaq,Tamuno Alfred,Najaf Amin,Dan E. Arking,Tin Aung,R. Graham Barr,Lawrence F. Bielak,Eric Boerwinkle,Eric Boerwinkle,Erwin P. Bottinger,Peter S. Braund,Peter S. Braund,Jennifer A. Brody,Ulrich Broeckel,Claudia P. Cabrera,Brian E. Cade,Yu Caizheng,Archie Campbell,Mickaël Canouil,Aravinda Chakravarti,Ganesh Chauhan,Kaare Christensen,Massimiliano Cocca,Francis S. Collins,John M. C. Connell,Renée de Mutsert,H. Janaka de Silva,Stéphanie Debette,Stéphanie Debette,Marcus Dörr,Qing Duan,Charles B. Eaton,Georg Ehret,Georg Ehret,Evangelos Evangelou,Evangelos Evangelou,Jessica D. Faul,Virginia Fisher,Nita G. Forouhi,Oscar H. Franco,Yechiel Friedlander,He Gao,Bruna Gigante,Misa Graff,C. Charles Gu,Dongfeng Gu,Preeti Gupta,Saskia P. Hagenaars,Tamara B. Harris,Jiang He,Sami Heikkinen,Chew-Kiat Heng,Chew-Kiat Heng,Makoto Hirata,Albert Hofman,Barbara V. Howard,Barbara V. Howard,Steven C. Hunt,Steven C. Hunt,Marguerite R. Irvin,Yucheng Jia,Roby Joehanes,Anne E. Justice,Tomohiro Katsuya,Joel D. Kaufman,Nicola D. Kerrison,Chiea Chuen Khor,Chiea Chuen Khor,Woon-Puay Koh,Heikki A. Koistinen,Heikki A. Koistinen,Pirjo Komulainen,Charles Kooperberg,José Eduardo Krieger,Michiaki Kubo,Johanna Kuusisto,Carl D. Langefeld,Claudia Langenberg,Lenore J. Launer,Benjamin Lehne,Cora E. Lewis,Yize Li,Sing Hui Lim,Shiow Lin,Ching-Ti Liu,Jianjun Liu,Jianjun Liu,Jingmin Liu,Kiang Liu,Y Liu,Marie Loh,Marie Loh,Kurt Lohman,Jirong Long,Tin Louie,Reedik Mägi,Anubha Mahajan,Thomas Meitinger,Andres Metspalu,Lili Milani,Yukihide Momozawa,Andrew P. Morris,Andrew P. Morris,Thomas H. Mosley,Peter J. Munson,Alison D. Murray,Mike A. Nalls,Ubaydah Nasri,Jill M. Norris,Kari E. North,Adesola Ogunniyi,Sandosh Padmanabhan,Walter Palmas,Nicholette D. Palmer,James S. Pankow,Nancy L. Pedersen,Annette Peters,Patricia A. Peyser,Ozren Polasek,Olli T. Raitakari,Olli T. Raitakari,Frida Renström,Frida Renström,Treva Rice,Paul M. Ridker,Antonietta Robino,Jennifer G. Robinson,Lynda M. Rose,Igor Rudan,Charumathi Sabanayagam,Babatunde L. Salako,Kevin Sandow,Carsten Oliver Schmidt,Pamela J. Schreiner,William R. Scott,William R. Scott,Sudha Seshadri,Peter S. Sever,Colleen M. Sitlani,Jennifer A. Smith,Harold Snieder,John M. Starr,Konstantin Strauch,Hua Tang,Kent D. Taylor,Yik Ying Teo,Yih Chung Tham,André G. Uitterlinden,Melanie Waldenberger,Lihua Wang,Ya X. Wang,Wen Bin Wei,Christine Williams,Gregory P. Wilson,Mary K. Wojczynski,Jie Yao,Jian-Min Yuan,Alan B. Zonderman,Diane M. Becker,Michael Boehnke,Donald W. Bowden,John C. Chambers,John C. Chambers,Yii-Der Ida Chen,Ulf de Faire,Ian J. Deary,Tõnu Esko,Tõnu Esko,Martin Farrall,Terrence Forrester,Paul W. Franks,Paul W. Franks,Paul W. Franks,Barry I. Freedman,Philippe Froguel,Philippe Froguel,Paolo Gasparini,Paolo Gasparini,Christian Gieger,Bernardo L. Horta,Yi-Jen Hung,Jost B. Jonas,Jost B. Jonas,Norihiro Kato,Jaspal S. Kooner,Jaspal S. Kooner,Markku Laakso,Terho Lehtimäki,Kae-Woei Liang,Kae-Woei Liang,Patrik K. E. Magnusson,Anne B. Newman,Albertine J. Oldehinkel,Alexandre C. Pereira,Alexandre C. Pereira,Susan Redline,Rainer Rettig,Nilesh J. Samani,Nilesh J. Samani,James Scott,Xiao-Ou Shu,Pim van der Harst,Lynne E. Wagenknecht,Nicholas J. Wareham,Hugh Watkins,David R. Weir,Ananda R. Wickremasinghe,Tangchun Wu,Wei Zheng,Yoichiro Kamatani,Cathy C. Laurie,Claude Bouchard,Richard S. Cooper,Michele K. Evans,Vilmundur Gudnason,Sharon L.R. Kardia,Stephen B. Kritchevsky,Daniel Levy,Jeffrey R. O'Connell,Bruce M. Psaty,Bruce M. Psaty,Rob M. van Dam,Mario Sims,Donna K. Arnett,Dennis O. Mook-Kanamori,Tanika N. Kelly,Ervin R. Fox,Caroline Hayward,Myriam Fornage,Charles N. Rotimi,Michael A. Province,Cornelia M. van Duijn,E. Shyong Tai,Tien Yin Wong,Ruth J. F. Loos,Alexander P. Reiner,Jerome I. Rotter,Xiaofeng Zhu,Laura J. Bierut,W. James Gauderman,Mark J. Caulfield,Paul Elliott,Kenneth Rice,Patricia B. Munroe,Alanna C. Morrison,L. Adrienne Cupples,Dabeeru C. Rao,Daniel I. Chasman +329 more
TL;DR: The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits and highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function.