H
Harry C. Tjondro
Researcher at Macquarie University
Publications - 12
Citations - 472
Harry C. Tjondro is an academic researcher from Macquarie University. The author has contributed to research in topics: Glycosylation & Glycome. The author has an hindex of 7, co-authored 11 publications receiving 360 citations. Previous affiliations of Harry C. Tjondro include Tsinghua University.
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Journal ArticleDOI
Lanosterol reverses protein aggregation in cataracts
Ling Zhao,Xiang-Jun Chen,Jie Zhu,Yi-Bo Xi,Xu Yang,Li-Dan Hu,Hong Ouyang,Sherrina Patel,Xin Jin,Danni Lin,Frances Wu,Ken Flagg,Huimin Cai,Gen Li,Guiqun Cao,Ying Lin,Daniel Chen,Cindy Wen,Christopher Chung,Yandong Wang,Austin Qiu,Emily Yeh,Wenqiu Wang,Xun Hu,Seanna Grob,Ruben Abagyan,Zhiguang Su,Harry C. Tjondro,Xi-Juan Zhao,Hongrong Luo,Rui Hou,J. Jefferson,P. Perry,Weiwei Gao,Igor Kozak,David B. Granet,Yingrui Li,Xiaodong Sun,Jun Wang,Liangfang Zhang,Yizhi Liu,Yong-Bin Yan,Kang Zhang +42 more
TL;DR: In this paper, the authors identify two distinct homozygous LSS missense mutations (W581R and G588S) in two families with extensive congenital cataracts.
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Human protein paucimannosylation: cues from the eukaryotic kingdoms
TL;DR: The literature supports the notion that PMPs are significant, yet still heavily under‐studied biomolecules in human glycobiology that serve essential functions and create structural heterogeneity not dissimilar to other human N‐glycoprotein types.
Journal ArticleDOI
Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase.
Harry C. Tjondro,Julian Ugonotti,Rebeca Kawahara,Sayantani Chatterjee,Ian Loke,Siyun Chen,Fabian Soltermann,Hannes Hinneburg,Benjamin L. Parker,Vignesh Venkatakrishnan,Regis Dieckmann,Oliver C. Grant,Johan Bylund,Alison Rodger,Robert J. Woods,Anna Karlsson-Bengtsson,Anna Karlsson-Bengtsson,Weston B. Struwe,Morten Thaysen-Andersen +18 more
TL;DR: Novel functional roles of MPO glycans are reported, providing new insight into neutrophil-mediated immunity and molecular modelling revealed that hyper-truncated Asn355-glycans positioned in the MPO-ceruloplasmin interface are critical for uninterrupted inhibition.
Journal ArticleDOI
Glycan analysis of human neutrophil granules implicates a maturation-dependent glycosylation machinery.
Vignesh Venkatakrishnan,Regis Dieckmann,Ian Loke,Harry C. Tjondro,Sayantani Chatterjee,Johan Bylund,Morten Thaysen-Andersen,Niclas G. Karlsson,Anna Karlsson-Bengtsson,Anna Karlsson-Bengtsson +9 more
TL;DR: This comprehensive neutrophil granule glycome map, the first of its kind, highlights novel granule-specific glycosylation features and is a crucial first step toward a better understanding of the mechanisms regulating protein glycosYLation during neutrophils granulopoiesis and a more detailed understanding of neutrophIL biology and function.
Journal ArticleDOI
Cataract-causing mutation R233H affects the stabilities of βB1- and βA3/βB1-crystallins with different pH-dependence.
Yi-Bo Xi,Wei-Jie Zhao,Xiao-Tong Zuo,Harry C. Tjondro,Jing Li,An-Bang Dai,Sha Wang,Yong-Bin Yan +7 more
TL;DR: It is proposed that the highly dynamic ion-pairing network contributed to the tradeoff among βB1 solubility, stability, aggregatory propensity and function of protecting βA3.