다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Although gold is the subject of one of the most ancient themes of investigation in science, its renaissance now leads to an exponentially increasing number of publications, especially in the context of emerging nanoscience and nanotechnology with nanoparticles and self-assembled monolayers (SAMs). We will limit the present review to gold nanoparticles (AuNPs), also called gold colloids. AuNPs are the most stable metal nanoparticles, and they present fascinating aspects such as their assembly of multiple types involving materials science, the behavior of the individual particles, size-related electronic, magnetic and optical properties (quantum size effect), and their applications to catalysis and biology. Their promises are in these fields as well as in the bottom-up approach of nanotechnology, and they will be key materials and building block in the 21st century. Whereas the extraction of gold started in the 5th millennium B.C. near Varna (Bulgaria) and reached 10 tons per year in Egypt around 1200-1300 B.C. when the marvelous statue of Touthankamon was constructed, it is probable that “soluble” gold appeared around the 5th or 4th century B.C. in Egypt and China. In antiquity, materials were used in an ecological sense for both aesthetic and curative purposes. Colloidal gold was used to make ruby glass 293 Chem. Rev. 2004, 104, 293−346

Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.

J. Appl. Cryst.の発刊に際して

Since the discovery of mechanically exfoliated graphene in 2004, research on ultrathin two-dimensional (2D) nanomaterials has grown exponentially in the fields of condensed matter physics, material science, chemistry, and nanotechnology. Highlighting their compelling physical, chemical, electronic, and optical properties, as well as their various potential applications, in this Review, we summarize the state-of-art progress on the ultrathin 2D nanomaterials with a particular emphasis on their recent advances. First, we introduce the unique advances on ultrathin 2D nanomaterials, followed by the description of their composition and crystal structures. The assortments of their synthetic methods are then summarized, including insights on their advantages and limitations, alongside some recommendations on suitable characterization techniques. We also discuss in detail the utilization of these ultrathin 2D nanomaterials for wide ranges of potential applications among the electronics/optoelectronics, electrocat...

Recent Advances in Ultrathin Two-Dimensional Nanomaterials

We report a case of “colonic type” adenocarcinoma of the appendix in a 35-year-old man. The preoperative diagnosis was acute appendicitis and emergent appendectomy was performed. Appendiceal cancer was diagnosed pathologically, and the stump was found to be positive for cancer. Right hemicolectomy was undertaken as a secondary procedure after the first operation due to the involvement of the cecum and lymph nodes. The histopathological diagnosis was well and moderately differentiated adenocarcinoma of the appendix. After the operation, the patient underwent chemotherapy. He has survived for 30 months after the colonic resection without any signs of recurrence.

/pdf/colonic-type-adenocarcinoma-of-the-appendix-report-of-a-case-3onm1v8c8n.pdf

Colonic Type Adenocarcinoma of the Appendix: Report of a Case and Review of Japanese Literature

Impedance Studies on Synergistic Inhibition Effect of Amines and Potassium Iodide on Iron Corrosion in 1N-H2SO4

Background/Aim: The Von Hippel-Lindau (VHL) gene encodes a protein (pVHL) that plays an important role in proteasome degradation of hypoxia inducible factor α (HIFα) through E3 activation. Accumulation of HIFα by loss of functional pVHL promotes tumorigenesis, thus, VHL has tumor suppressor gene capability in clear cell renal cell carcinoma (ccRCC). VHL is the most frequently mutated gene in ccRCC. The complete loss of VHL is mainly achieved by loss of chromosome 3p, which has a VHL coding region in combination with mutation or hypermethylation of the remaining copy of VHL. Given the risk of constitutional chromosome 3 translocation for RCC, it is important to detect the translocation and understand the mechanism underlying the development of multifocal ccRCC. Case Report: A 67-year-old female patient diagnosed with multifocal RCC underwent robot-assisted partial nephrectomy (RAPN) for three kidney tumors. A cancer gene panel test using next generation sequencing (NGS) detected differential VHL mutations (c.533T>G; p.L178R, c.465_466insTA; p.T157Ifs*3, c.343C>A; p.H115N), while VHL mutation was not detected in peripheral blood DNA. A tendency toward copy number loss of genes on der(3) was also detected in all tumors, but not in the germline one. A karyotype analysis revealed a germline translocation between 3 and 6, t(3;6)(q12;q14). Conclusion: Chromosome 3 translocation and loss of derivative chromosome containing 3p and subsequent somatic differential VHL mutations in this case strongly support the previously proposed three-step model to explain the development of familial conventional ccRCC.

Derivative Chromosome 3 Loss from t(3;6)(q12;q14) Followed by Differential VHL Mutations Underlie Multifocal ccRCC

Hybridisation chain reaction-based visualisation and screening for lncRNA profiles in clear-cell renal-cell carcinoma

as a promising method for this purpose.' Recently, the usefulness of a corner-cube array as a convenient and simple means for this purpose has also been reported.' In the latter method, however, the conjugation of the wave front is accomplished essentially only within each corner-cube element. Hence smooth conjugation over a large aperture cannot be realized, and the range of applications is restricted. In this paper a new phase conjugator with fairly simple construction that can be applied to large aperture wave front is proposed. In this system each element of a corner-cube array is controlled independently by the corresponding PMN actuator. Hence it may be considered as a COAT system whose elements consist of corner cubes instead of plane mirror^.^ Piston control of each element realizes continuation of the generated wave front over the aperture. Roughly speaking, if the number of the elements of the conventional COAT is N, about fielements are enough to get the same quality of conjugated wave front in the new system. The setup for the experiments is shown in Fig. 1. Some results are shown in Fig. 2. In this case we can see clearly that the corner-cube array COAT corrects the distorted wave front, while the conventional mirror COAT fails to do so. The details of the numerical analyses and further experimental results will be given at the conference.

Hiroshi Nishihara

Papers

Colonic Type Adenocarcinoma of the Appendix: Report of a Case and Review of Japanese Literature

Impedance Studies on Synergistic Inhibition Effect of Amines and Potassium Iodide on Iron Corrosion in 1N-H2SO4

Derivative Chromosome 3 Loss from t(3;6)(q12;q14) Followed by Differential VHL Mutations Underlie Multifocal ccRCC

Hybridisation chain reaction-based visualisation and screening for lncRNA profiles in clear-cell renal-cell carcinoma

Optical-fiber high-resolution LDV for pulsatile blood flows