H
Holly J. Snyder
Researcher at Columbia University
Publications - 6
Citations - 1467
Holly J. Snyder is an academic researcher from Columbia University. The author has contributed to research in topics: Genome-wide association study & Exome sequencing. The author has an hindex of 5, co-authored 5 publications receiving 1120 citations.
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Journal ArticleDOI
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens
Krzysztof Kiryluk,Yifu Li,Francesco Scolari,Simone Sanna-Cherchi,Murim Choi,Miguel Verbitsky,David Fasel,Sneh Lata,Sindhuri Prakash,Samantha Shapiro,Clara Fischman,Holly J. Snyder,Gerald B. Appel,Claudia Izzi,Battista Fabio Viola,Nadia Dallera,Lucia Del Vecchio,Cristina Barlassina,Erika Salvi,Francesca Bertinetto,Antonio Amoroso,Silvana Savoldi,Marcella Rocchietti,Alessandro Amore,Licia Peruzzi,Rosanna Coppo,Maurizio Salvadori,Pietro Ravani,Riccardo Magistroni,Gian Marco Ghiggeri,Gianluca Caridi,Monica Bodria,Francesca Lugani,Landino Allegri,Marco Delsante,Mariarosa Maiorana,Andrea Magnano,Giovanni M. Frascà,Emanuela Boer,Giuliano Boscutti,Claudio Ponticelli,Renzo Mignani,Carmelita Marcantoni,Domenico Di Landro,Domenico Santoro,Antonello Pani,Rosaria Polci,Sandro Feriozzi,Silvana Chicca,Marco Galliani,Maddalena Gigante,Loreto Gesualdo,Pasquale Zamboli,Giovanni Giorgio Battaglia,Maurizio Garozzo,Dita Maixnerova,Vladimir Tesar,Frank Eitner,Thomas Rauen,Jürgen Floege,Tibor Kovács,Judit Nagy,Krzysztof Mucha,Leszek Pączek,Marcin Zaniew,Małgorzata Mizerska-Wasiak,Maria Roszkowska-Blaim,Krzysztof Pawlaczyk,Daniel P. Gale,Jonathan Barratt,Lise Thibaudin,François Berthoux,Guillaume Canaud,Anne Boland,Marie Metzger,Ulf Panzer,Hitoshi Suzuki,Shin Goto,Ichiei Narita,Yasar Caliskan,Jingyuan Xie,Ping Hou,Nan Chen,Hong Zhang,Robert J. Wyatt,Jan Novak,Bruce A. Julian,John Feehally,Bénédicte Stengel,Daniele Cusi,Richard P. Lifton,Ali G. Gharavi +91 more
TL;DR: A genome-wide association study of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry is performed, suggesting a possible role for host–intestinal pathogen interactions in shaping the genetic landscape of IgAN.
Journal ArticleDOI
Diagnostic Utility of Exome Sequencing for Kidney Disease
Emily E. Groopman,Maddalena Marasa,Sophia R. Cameron-Christie,Slavé Petrovski,Vimla Aggarwal,Hila Milo-Rasouly,Yifu Li,Junying Zhang,Jordan G. Nestor,Priya Krithivasan,Wan Yee Lam,Adele Mitrotti,Stacy Piva,Byum Hee Kil,Debanjana Chatterjee,Rachel Reingold,Drew Bradbury,Michael DiVecchia,Holly J. Snyder,Xueru Mu,Karla Mehl,Olivia Balderes,David Fasel,Chunhua Weng,Jai Radhakrishnan,Pietro A. Canetta,Gerald B. Appel,Andrew S. Bomback,Wooin Ahn,Natalie S Uy,Shumyle Alam,David J. Cohen,Russell J. Crew,Geoffrey K. Dube,Maya K. Rao,Sitharthan Kamalakaran,Brett Copeland,Zhong Ren,Joshua Bridgers,Colin D. Malone,Caroline Mebane,Neha Dagaonkar,Bengt Fellström,Carolina Haefliger,Sumit Mohan,Simone Sanna-Cherchi,Krzysztof Kiryluk,Jan Fleckner,Ruth March,Adam Platt,David Goldstein,Ali G. Gharavi +51 more
TL;DR: Exome sequencing in a combined cohort of more than 3000 patients with chronic kidney disease yielded a genetic diagnosis in just under 10% of cases, with genetic findings for medically actionable disorders that would also lead to subspecialty referral and inform renal management.
Journal ArticleDOI
Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis
Krzysztof Kiryluk,Yifu Li,Simone Sanna-Cherchi,Simone Sanna-Cherchi,Mersedeh Rohanizadegan,Hitoshi Suzuki,Frank Eitner,Holly J. Snyder,Murim Choi,Ping Hou,Francesco Scolari,Claudia Izzi,Maddalena Gigante,Loreto Gesualdo,Silvana Savoldi,Antonio Amoroso,Daniele Cusi,Pasquale Zamboli,Bruce A. Julian,Jan Novak,Robert J. Wyatt,Robert J. Wyatt,Krzysztof Mucha,Markus Perola,Markus Perola,Markus Perola,Kati Kristiansson,Alexander Viktorin,Patrik K. E. Magnusson,Gudmar Thorleifsson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Anne Boland,Marie Metzger,Lise Thibaudin,Christoph Wanner,Kitty J Jager,Shin Goto,Dita Maixnerova,Hussein H. Karnib,Judit Nagy,Ulf Panzer,Jingyuan Xie,Nan Chen,Vladimir Tesar,Ichiei Narita,François Berthoux,Juergen Floege,Bénédicte Stengel,Hong Zhang,Richard P. Lifton,Ali G. Gharavi +54 more
TL;DR: Variation at IgAN susceptibility loci correlates with differences in disease prevalence among world populations and inform genetic, biological, and epidemiological investigations of IgAN and permit cross-comparison with other complex traits that share genetic risk loci and geographic patterns with IgAN.
Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis
Krzysztof Kiryluk,Yifu Li,Simone Sanna-Cherchi,Simone Sanna-Cherchi,Mersedeh Rohanizadegan,Hitoshi Suzuki,Frank Eitner,Holly J. Snyder,Murim Choi,Ping Hou,Francesco Scolari,Claudia Izzi,Maddalena Gigante,Loreto Gesualdo,Silvana Savoldi,Antonio Amoroso,Daniele Cusi,Pasquale Zamboli,Bruce A. Julian,Jan Novak,Robert J. Wyatt,Robert J. Wyatt,Krzysztof Mucha,Markus Perola,Markus Perola,Markus Perola,Kati Kristiansson,Alexander Viktorin,Patrik K. E. Magnusson,Gudmar Thorleifsson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Anne Boland,Marie Metzger,Lise Thibaudin,Christoph Wanner,Kitty J Jager,Shin Goto,Dita Maixnerova,Hussein H. Karnib,Judit Nagy,Ulf Panzer,Jingyuan Xie,Nan Chen,Vladimir Tesar,Ichiei Narita,François Berthoux,Juergen Floege,Bénédicte Stengel,Hong Zhang,Richard P. Lifton,Ali G. Gharavi +54 more
TL;DR: In this article, the authors localized five IgAN susceptibility loci on Chr.6p21 (HLA-DQB1/DRB1, PSMB9/TAP1, and DPA1/DPB2 loci), Chr.1q32 (CFHR3/R1 locus), and Chr.22q12 (HORMAD2 locus) and tested association of these loci in eight new independent cohorts of Asian, European, and African-American ancestry.
Journal ArticleDOI
APOL1 Variants Increase Risk for FSGS and HIVAN but Not IgA Nephropathy
Natalia Papeta,Krzysztof Kiryluk,Ami Patel,Roel Sterken,Nilgun Kacak,Holly J. Snyder,Phil H. Imus,Anand N. Mhatre,Anil K. Lawani,Bruce A. Julian,Robert J. Wyatt,Jan Novak,Christina M. Wyatt,Michael W. Ross,Jonathan A. Winston,Mary E. Klotman,David J. Cohen,Gerald B. Appel,Vivette D. D'Agati,Paul E. Klotman,Ali G. Gharavi +20 more
TL;DR: Examination of genetic variants in APOL1 with susceptibility to FSGS and HIVAN among African Americans and crossbred Myh9-haploinsufficient mice with HIV-1 transgenic mice helps to assess the role of MYH9 deficiency in nephropathy.