Jingyuan Xie

TL;DR: A genome-wide association study of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry is performed, suggesting a possible role for host–intestinal pathogen interactions in shaping the genetic landscape of IgAN.

TL;DR: The data indicate that IgAN patients with higher systolic blood pressure, lower eGFR, hemoglobin, and albumin levels at baseline are at a greatest risk of progression to ESRD, and a 4-variable equation of a clinical risk score for disease progression is developed.

TL;DR: Patients with anemia were more likely to have one or more comorbidities and severe COVID‐19 illness, and healthcare professionals should be more sensitive to the hemoglobin levels of CO VID‐19 patients on admission.

TL;DR: The findings highlight an unusual genetic architecture of MN, with four loci and their interactions accounting for nearly one-third of the disease risk.

TL;DR: A quantitative GWAS for serum levels of galactose-deficient IgA1 (Gd-IgA1) in 2,633 subjects of European and East Asian ancestry and discovered two genome-wide significant loci, in C1GALT1 and C1gALT1C1, which encode molecular partners essential for enzymatic O-glycosylation of IgA 1.