M
Maddalena Gigante
Researcher at University of Foggia
Publications - 44
Citations - 2593
Maddalena Gigante is an academic researcher from University of Foggia. The author has contributed to research in topics: Nephrin & Mutation. The author has an hindex of 22, co-authored 43 publications receiving 2164 citations. Previous affiliations of Maddalena Gigante include University of Bari & University of Turin.
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Journal ArticleDOI
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens
Krzysztof Kiryluk,Yifu Li,Francesco Scolari,Simone Sanna-Cherchi,Murim Choi,Miguel Verbitsky,David Fasel,Sneh Lata,Sindhuri Prakash,Samantha Shapiro,Clara Fischman,Holly J. Snyder,Gerald B. Appel,Claudia Izzi,Battista Fabio Viola,Nadia Dallera,Lucia Del Vecchio,Cristina Barlassina,Erika Salvi,Francesca Bertinetto,Antonio Amoroso,Silvana Savoldi,Marcella Rocchietti,Alessandro Amore,Licia Peruzzi,Rosanna Coppo,Maurizio Salvadori,Pietro Ravani,Riccardo Magistroni,Gian Marco Ghiggeri,Gianluca Caridi,Monica Bodria,Francesca Lugani,Landino Allegri,Marco Delsante,Mariarosa Maiorana,Andrea Magnano,Giovanni M. Frascà,Emanuela Boer,Giuliano Boscutti,Claudio Ponticelli,Renzo Mignani,Carmelita Marcantoni,Domenico Di Landro,Domenico Santoro,Antonello Pani,Rosaria Polci,Sandro Feriozzi,Silvana Chicca,Marco Galliani,Maddalena Gigante,Loreto Gesualdo,Pasquale Zamboli,Giovanni Giorgio Battaglia,Maurizio Garozzo,Dita Maixnerova,Vladimir Tesar,Frank Eitner,Thomas Rauen,Jürgen Floege,Tibor Kovács,Judit Nagy,Krzysztof Mucha,Leszek Pączek,Marcin Zaniew,Małgorzata Mizerska-Wasiak,Maria Roszkowska-Blaim,Krzysztof Pawlaczyk,Daniel P. Gale,Jonathan Barratt,Lise Thibaudin,François Berthoux,Guillaume Canaud,Anne Boland,Marie Metzger,Ulf Panzer,Hitoshi Suzuki,Shin Goto,Ichiei Narita,Yasar Caliskan,Jingyuan Xie,Ping Hou,Nan Chen,Hong Zhang,Robert J. Wyatt,Jan Novak,Bruce A. Julian,John Feehally,Bénédicte Stengel,Daniele Cusi,Richard P. Lifton,Ali G. Gharavi +91 more
TL;DR: A genome-wide association study of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry is performed, suggesting a possible role for host–intestinal pathogen interactions in shaping the genetic landscape of IgAN.
Journal ArticleDOI
Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis
Krzysztof Kiryluk,Yifu Li,Simone Sanna-Cherchi,Simone Sanna-Cherchi,Mersedeh Rohanizadegan,Hitoshi Suzuki,Frank Eitner,Holly J. Snyder,Murim Choi,Ping Hou,Francesco Scolari,Claudia Izzi,Maddalena Gigante,Loreto Gesualdo,Silvana Savoldi,Antonio Amoroso,Daniele Cusi,Pasquale Zamboli,Bruce A. Julian,Jan Novak,Robert J. Wyatt,Robert J. Wyatt,Krzysztof Mucha,Markus Perola,Markus Perola,Markus Perola,Kati Kristiansson,Alexander Viktorin,Patrik K. E. Magnusson,Gudmar Thorleifsson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Anne Boland,Marie Metzger,Lise Thibaudin,Christoph Wanner,Kitty J Jager,Shin Goto,Dita Maixnerova,Hussein H. Karnib,Judit Nagy,Ulf Panzer,Jingyuan Xie,Nan Chen,Vladimir Tesar,Ichiei Narita,François Berthoux,Juergen Floege,Bénédicte Stengel,Hong Zhang,Richard P. Lifton,Ali G. Gharavi +54 more
TL;DR: Variation at IgAN susceptibility loci correlates with differences in disease prevalence among world populations and inform genetic, biological, and epidemiological investigations of IgAN and permit cross-comparison with other complex traits that share genetic risk loci and geographic patterns with IgAN.
Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis
Krzysztof Kiryluk,Yifu Li,Simone Sanna-Cherchi,Simone Sanna-Cherchi,Mersedeh Rohanizadegan,Hitoshi Suzuki,Frank Eitner,Holly J. Snyder,Murim Choi,Ping Hou,Francesco Scolari,Claudia Izzi,Maddalena Gigante,Loreto Gesualdo,Silvana Savoldi,Antonio Amoroso,Daniele Cusi,Pasquale Zamboli,Bruce A. Julian,Jan Novak,Robert J. Wyatt,Robert J. Wyatt,Krzysztof Mucha,Markus Perola,Markus Perola,Markus Perola,Kati Kristiansson,Alexander Viktorin,Patrik K. E. Magnusson,Gudmar Thorleifsson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Anne Boland,Marie Metzger,Lise Thibaudin,Christoph Wanner,Kitty J Jager,Shin Goto,Dita Maixnerova,Hussein H. Karnib,Judit Nagy,Ulf Panzer,Jingyuan Xie,Nan Chen,Vladimir Tesar,Ichiei Narita,François Berthoux,Juergen Floege,Bénédicte Stengel,Hong Zhang,Richard P. Lifton,Ali G. Gharavi +54 more
TL;DR: In this article, the authors localized five IgAN susceptibility loci on Chr.6p21 (HLA-DQB1/DRB1, PSMB9/TAP1, and DPA1/DPB2 loci), Chr.1q32 (CFHR3/R1 locus), and Chr.22q12 (HORMAD2 locus) and tested association of these loci in eight new independent cohorts of Asian, European, and African-American ancestry.
Journal ArticleDOI
Copy-Number Disorders Are a Common Cause of Congenital Kidney Malformations
Simone Sanna-Cherchi,Krzysztof Kiryluk,Katelyn Elizabeth Burgess,Monica Bodria,Matthew G. Sampson,Dexter Hadley,Shannon N. Nees,Miguel Verbitsky,Brittany J. Perry,Roel Sterken,Vladimir J Lozanovski,Anna Materna-Kiryluk,Cristina Barlassina,Akshata Kini,Valentina Corbani,Alba Carrea,Danio Somenzi,Corrado Murtas,Nadica Ristoska-Bojkovska,Claudia Izzi,Beatrice Bianco,Marcin Zaniew,Hana Flögelová,Patricia L. Weng,Nilgun Kacak,Stefania Giberti,Maddalena Gigante,Adela Arapović,Kristina Drnasin,Gianluca Caridi,Simona Curioni,Franca Allegri,Anita Ammenti,Stefania Ferretti,Vinicio Goj,Luca Bernardo,Vaidehi Jobanputra,Wendy K. Chung,Richard P. Lifton,Stephen Sanders,Matthew W. State,Lorraine N. Clark,Marijan Saraga,Sandosh Padmanabhan,Anna F. Dominiczak,Tatiana Foroud,Loreto Gesualdo,Zoran Gucev,Landino Allegri,Anna Latos-Bielenska,Daniele Cusi,Francesco Scolari,Velibor Tasic,Hakon Hakonarson,Gian Marco Ghiggeri,Ali G. Gharavi +55 more
TL;DR: The majority of the known CNV disorders detected in the RHD cohort have previous associations with developmental delay or neuropsychiatric diseases and should be considered in this population for the diagnosis of their specific genomic disorders and for the evaluation of the potential for developmental delay.
Journal ArticleDOI
The Molecular Basis of Lecithin:Cholesterol Acyltransferase Deficiency Syndromes: A Comprehensive Study of Molecular and Biochemical Findings in 13 Unrelated Italian Families
Laura Calabresi,Livia Pisciotta,Anna Costantin,Ilaria Frigerio,Ivano Eberini,Paola Alessandrini,Marcello Arca,Gabriele Bittolo Bon,Giuliano Boscutti,Busnach G,Giovanni M. Frascà,Loreto Gesualdo,Maddalena Gigante,Graziana Lupattelli,Anna Montali,Stefano Pizzolitto,Ivana Rabbone,M. Rolleri,Giacomo Ruotolo,Tiziana Sampietro,Adalberto Sessa,Gaetano Vaudo,Alfredo Cantafora,Fabrizio Veglia,Sebastiano Calandra,Stefano Bertolini,Guido Franceschini +26 more
TL;DR: In a large series of subjects carrying mutations in the LCAT gene, the inheritance of a mutated LCAT genotype causes a gene–dose-dependent alteration in the plasma lipid/lipoprotein profile, which is remarkably similar between subjects classified as FLD or FED.