James Blanchard

TL;DR: It is demonstrated that CD8 cells play a crucial role in suppressing SIV replication in vivo and are examined using an anti-CD8 monoclonal antibody, OKT8F.

TL;DR: A critical role of co-receptor utilization in viral pathogenesis is suggested and in vivo infection with chimeric simian-human immunodeficiency virus provides a reliable in vivo model for preclinical examination of HIV-1 vaccines and therapeutic agents in the context of the HIV- 1 envelope protein.

TL;DR: The efficient mucosal transmission of a CCR5-specific chimeric simian/human immunodeficiency virus, SHIVSF162P3, is described and this controlled model provides the setting to investigate immunologic responses and putative host-specific susceptibility factors that alter viral transmission and subsequent disease progression.

TL;DR: It is shown that aerosol immunization of macaques with the Mtb mutant in SigH (MtbΔsigH) results in significant recruitment of inducible bronchus-associated lymphoid tissue (iBALT) as well as CD4+ and CD8+ T cells expressing activation and proliferation markers to the lungs.

TL;DR: This analysis identifies Th17-lineage CCR6+ CD4+ T cells as primary targets of SIV during vaginal transmission, which opens new opportunities for interventions to protect these cells and prevent HIV transmission.