J
James Blanchard
Researcher at Tulane University
Publications - 119
Citations - 5958
James Blanchard is an academic researcher from Tulane University. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 37, co-authored 119 publications receiving 5460 citations.
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Journal ArticleDOI
Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques
Xia Jin,Daniel E. Bauer,Sarah Tuttleton,Sharon R Lewin,Agegnehu Gettie,James Blanchard,Craig E. Irwin,Jeffrey T. Safrit,John E. Mittler,Leor S. Weinberger,Leondios G. Kostrikis,Linqi Zhang,Alan S. Perelson,David D. Ho +13 more
TL;DR: It is demonstrated that CD8 cells play a crucial role in suppressing SIV replication in vivo and are examined using an anti-CD8 monoclonal antibody, OKT8F.
Journal ArticleDOI
Distinct pathogenic sequela in rhesus macaques infected with CCR5 or CXCR4 utilizing SHIVs
TL;DR: A critical role of co-receptor utilization in viral pathogenesis is suggested and in vivo infection with chimeric simian-human immunodeficiency virus provides a reliable in vivo model for preclinical examination of HIV-1 vaccines and therapeutic agents in the context of the HIV- 1 envelope protein.
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Mucosal transmission and induction of simian AIDS by CCR5-specific simian/human immunodeficiency virus SHIV(SF162P3).
Janet M. Harouse,Agegnehu Gettie,Tadesse Eshetu,Rei Chin How Tan,Rudolf P. Bohm,James Blanchard,Gary B. Baskin,Cecilia Cheng-Mayer +7 more
TL;DR: The efficient mucosal transmission of a CCR5-specific chimeric simian/human immunodeficiency virus, SHIVSF162P3, is described and this controlled model provides the setting to investigate immunologic responses and putative host-specific susceptibility factors that alter viral transmission and subsequent disease progression.
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Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis.
Deepak Kaushal,Taylor W. Foreman,Uma S. Gautam,Xavier Alvarez,Toidi Adekambi,Toidi Adekambi,Javier Rangel-Moreno,Nadia A. Golden,Ann-Marie Johnson,Bonnie L. Phillips,Muhammad H. Ahsan,Kasi E. Russell-Lodrigue,Lara A. Doyle,Chad J. Roy,Peter J. Didier,James Blanchard,Jyothi Rengarajan,Jyothi Rengarajan,Andrew A. Lackner,Shabaana A. Khader,Smriti Mehra,Smriti Mehra +21 more
TL;DR: It is shown that aerosol immunization of macaques with the Mtb mutant in SigH (MtbΔsigH) results in significant recruitment of inducible bronchus-associated lymphoid tissue (iBALT) as well as CD4+ and CD8+ T cells expressing activation and proliferation markers to the lungs.
Journal ArticleDOI
Th17 Cells Are Preferentially Infected Very Early after Vaginal Transmission of SIV in Macaques.
Daniel J. Stieh,Edgar Matias,Huanbin Xu,Angela J. Fought,James Blanchard,Preston A. Marx,Ronald S. Veazey,Thomas J. Hope +7 more
TL;DR: This analysis identifies Th17-lineage CCR6+ CD4+ T cells as primary targets of SIV during vaginal transmission, which opens new opportunities for interventions to protect these cells and prevent HIV transmission.