J
James Hill
Researcher at University of Manchester
Publications - 220
Citations - 8506
James Hill is an academic researcher from University of Manchester. The author has contributed to research in topics: Lynch syndrome & Cancer. The author has an hindex of 47, co-authored 216 publications receiving 6837 citations. Previous affiliations of James Hill include Vanderbilt University & Morehouse College.
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Journal ArticleDOI
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
Pål Møller,Toni T. Seppälä,Inge Bernstein,Inge Bernstein,Elke Holinski-Feder,Paulo Sala,D. Gareth Evans,D. Gareth Evans,Annika Lindblom,Finlay A. Macrae,Finlay A. Macrae,Ignacio Blanco,Rolf H. Sijmons,Jacqueline Jeffries,Hans F. A. Vasen,John Burn,Sigve Nakken,Eivind Hovig,Einar Andreas Rødland,Kukatharmini Tharmaratnam,Wouter H. de Vos tot Nederveen Cappel,James Hill,Juul T. Wijnen,Mark A. Jenkins,Kate Green,Kate Green,Fiona Lalloo,Fiona Lalloo,Lone Sunde,Miriam Mints,Lucio Bertario,Marta Pineda,Matilde Navarro,Monika Morak,Laura Renkonen-Sinisalo,Laura Renkonen-Sinisalo,Mev Dominguez Valentin,Ian M. Frayling,John-Paul Plazzer,Kirsi Pylvänäinen,Maurizio Genuardi,Jukka-Pekka Mecklin,Gabriela Moeslein,Julian R. Sampson,Gabriel Capellá +44 more
TL;DR: Carriers of different path_MMR variants exhibit distinct patterns of cancer risk and survival as they age, and risk estimates for counselling and planning of surveillance and treatment should be tailored to each patient’s age, gender and path-MMR variant.
Journal ArticleDOI
A predictive model for local recurrence after transanal endoscopic microsurgery for rectal cancer.
Simon P. Bach,James Hill,John R. T. Monson,J. N. L. Simson,L. Lane,Arend E. H. Merrie,Bryan F. Warren,N. J. McC. Mortensen +7 more
TL;DR: The outcome of local excision of early rectal cancer using transanal endoscopic microsurgery (TEM) lacks consensus and patients need local treatments that are oncologically equivalent to radical surgery but safer and functionally superior.
Journal ArticleDOI
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Mev Dominguez-Valentin,Julian R. Sampson,Toni T. Seppälä,Sanne W. ten Broeke,John-Paul Plazzer,Sigve Nakken,Christoph Engel,Stefan Aretz,Mark A. Jenkins,Lone Sunde,Lone Sunde,Inge Bernstein,Gabriel Capellá,Francesc Balaguer,Huw D. Thomas,D. Gareth Evans,D. Gareth Evans,John Burn,Marc S. Greenblatt,Eivind Hovig,Wouter H. de Vos tot Nederveen Cappel,Rolf H. Sijmons,Lucio Bertario,Maria Grazia Tibiletti,Giulia Martina Cavestro,Annika Lindblom,Adriana Della Valle,Francisco López-Köstner,Nathan Gluck,Lior H. Katz,Karl Heinimann,Carlos A. Vaccaro,Reinhard Büttner,Heike Görgens,Elke Holinski-Feder,Monika Morak,Stefanie Holzapfel,Robert Hüneburg,Magnus von Knebel Doeberitz,Magnus von Knebel Doeberitz,Markus Loeffler,Nils Rahner,Hans K. Schackert,Verena Steinke-Lange,Wolff Schmiegel,Deepak Vangala,Kirsi Pylvänäinen,Laura Renkonen-Sinisalo,Laura Renkonen-Sinisalo,John L. Hopper,Aung Ko Win,Robert W. Haile,Noralane M. Lindor,Steven Gallinger,Loic Le Marchand,Polly A. Newcomb,Jane C. Figueiredo,Stephen N. Thibodeau,Karin Wadt,Christina Therkildsen,Henrik Okkels,Zohreh Ketabi,Leticia Moreira,Ariadna Sánchez,Miquel Serra-Burriel,Marta Pineda,Matilde Navarro,Ignacio Blanco,Kate Green,Fiona Lalloo,Emma J Crosbie,James Hill,Oliver G. Denton,Ian M. Frayling,Einar Andreas Rødland,Hans F. A. Vasen,Miriam Mints,Florencia Neffa,Patricia Esperon,Karin Alvarez,Revital Kariv,Guy Rosner,Tamara Alejandra Piñero,María Laura Gonzalez,Pablo Kalfayan,Douglas Tjandra,Ingrid Winship,Ingrid Winship,Finlay A. Macrae,Finlay A. Macrae,Gabriela Möslein,Jukka-Pekka Mecklin,Maartje Nielsen,Pål Møller,Pål Møller +94 more
TL;DR: Management guidelines for Lynch syndrome may require revision in light of these different gene and gender-specific risks and the good prognosis for the most commonly associated cancers.
Journal ArticleDOI
Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: the pilot phase of a randomised controlled trial
D. A. Agbamu,N. Day,C. J. Walsh,C. W. Hendrickse,G. Langman,A. Pallan,A. Lowe,J. Ostrowski,M. Steward,M. Callaway,Stephen Falk,Michael Thomas,N. Wong,J. Hartley,A. W. MacDonald,D. Blunt,P. Cohen,P. Dawson,Charles Lowdell,D. Furniss,R. Gupta,R. D. Taraporewalla,Michael Braun,N. Cruickshank,S. Muzaffar,David J. Smith,F. Daniel,J. Denson,Stephen H D Jackson,K. Sleigh,E. Kweka,H. J. Pearson,M. Peters,Rajarshi Roy,G. Kurien,J. Robinson,Jonathan Wadsley,D. White,M. J. Lamparelli,J. Mikel,R. Osborne,P. Taylor,I. C. Ilesley,Brendan J. Moran,H. O'Neill,Charlotte Rees,A. Buxton,J. Harrison,D. Scullion,J. Hyde,D. Ilsley,U. Raja,Corran Roberts,M. Crabtree,J. Orrell,Sarah Smith,Rubin Soomal,James Hill,G. Howarth,S. Lee,R. Church,A. Hartley,C. Holland,A. K. Thompson,Rob Glynne-Jones,J. Livingstone,P. Richman,M. Train,C. Barlow,P. Burn,J. Geraghty,C. J. Vickery,J. Walther,Simon Aird Grumett,S. A.M. Mangalika,M. Qaiyum,Geraint T. Williams,R. Borgstein,John Bridgewater,L. Meleagros,J. A. Rees,S. J. Needham,Jacob G. Scott,A. Anathhanam,J. Brittenden,C. Macklin,Daniel Swinson,J. Alexander,Tamas Hickish,R. W. Talbot,D. Tarver,O. Lalude,W. Partridge,V. Sundaresan,D. Cowlishaw,A. Higginson,S. R. Muthuramalingam,D. P. O'Leary,B. T. Ismail,Dion Morton,A. Page,N. Steven,Phillipe Taniere,J. Gutmann,J. Huang,Sherif Raouf,I. T. Saeed,W. K. Dunn,Vanessa Potter,J. H. Scholefield,A. Zaitoun,D. Eason,G. Stenhouse,K. G. Walker,A. J. Watson,D. Whillis,B. Fozard,J. McCutcheon,S. Snape,Richard J. Ellis,W. Faux,G. Maskell,J. Mathew,J. R.G. Bell,A Mayer,O. A. Ogunbiyi,J. Watkins,C. Bronder,D. Eaton,N. Mapstone,Angela E Taylor,Gina Brown,David Cunningham,Paris P. Tekkis,A C Wotherspoon,D. Barber,M. Dobson,M. Pitt,N. Scot,S. Susnerwala,David Ferry,Andrew J. Hall,A. Kawesha,A. Sherif,Graham Branagan,S. Cook,Clifton D. Fuller,T. Iveson,R. Donovan,D. Peake,S. M. Ahmad,A. Coup,A. Hamid,D. Pai,A. C. Bateman,Andrew Bateman,R. M. Blaquiere,P. Nichols,M. J. Dworkin,S. Jain,A. Malhotra,B. Pravee,D. Tsang,K. Hopkins,E. Loveday,Anne Pullyblank,N. Rooney,A. Chiphang,S. Dundas,A. S. Myint,M. Zeiderman,N. Beharry,Caroline Finlayson,R. Hagger,F. Lofts,D. M. Melville,Paul J. Finan,Nigel Scott,Matthew T. Seymour,D. Tolan,Jurjees Hasan,V. Howarth,Samir Mehta,M. Saeed,Fiona Campbell,M. L. Hughes,P. Rooney,F. Adab,I. Britton,Carolyn S. Hall,C. Phelan,A. Moss,N. Pranesh,D. Shareef,J. Whalley,Rizvana Ahmad,Sujal R. Desai,S. Ramesh,C. Ramsey,S. Amin,J. Hampton,Joanne Hornbuckle,P. Kitsanta,A. L. Desai,Marcia Hall,M. Thyveetil,A. Baxter,David Farrugia,S. P. Lake,Tracy E Roberts,G. T. Smith,M. Charig,T. Burdge,P. Chandran,C. Corr,Simon Gollins,S. Pritchard,M. Scott,S. Sukumar,A. Clarke,J. Haselden,N. Woodcock,A. Maw,C. Bale,E. Favill,M. Clwyd,W. Atkinson,M. Gupta,H. Burnett,S. Hayes,N. Lees +230 more
TL;DR: The FOxTROT trial aims to investigate the feasibility, safety, and efficacy of preoperative chemotherapy for colon cancer, and to establish whether the encouraging pathological responses seen with preoperative therapy translates into improved long-term oncological outcome.
Journal ArticleDOI
The beneficial plant growth-promoting association of Rhizobium leguminosarum bv. trifolii with rice roots
Youssef G. Yanni,R. Rizk,Faiza K. Abd El-Fattah,Andrea Squartini,Viviana Corich,Alessio Giacomini,Frans J. de Bruijn,J. L. W. Rademaker,Jaime Maya-Flores,Peggy Ostrom,Maria Vega-Hernandez,Rawle I. Hollingsworth,Eustoquio Martínez-Molina,Pedro F. Mateos,Encarna Velázquez,Judith Wopereis,Eric W. Triplett,Mercedes Umali-Garcia,Juliet A. Anarna,B. G. Rolfe,Jadish K. Ladha,James Hill,Rajni Mujoo,Perry K.W. Ng,Frank B. Dazzo +24 more
TL;DR: His paper summarizes a multinational collaborative project to search for natural, intimate associations between rhizobia and rice, assess their impact on plant growth, and exploit those combinations that can enhance grain yield with less dependence on inputs of nitrogen (N) fertilizer.