O
Oliver G. Denton
Researcher at Cardiff University
Publications - 5
Citations - 371
Oliver G. Denton is an academic researcher from Cardiff University. The author has contributed to research in topics: Lynch syndrome & Cancer. The author has an hindex of 2, co-authored 4 publications receiving 161 citations.
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Journal ArticleDOI
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Mev Dominguez-Valentin,Julian R. Sampson,Toni T. Seppälä,Sanne W. ten Broeke,John-Paul Plazzer,Sigve Nakken,Christoph Engel,Stefan Aretz,Mark A. Jenkins,Lone Sunde,Lone Sunde,Inge Bernstein,Gabriel Capellá,Francesc Balaguer,Huw D. Thomas,D. Gareth Evans,D. Gareth Evans,John Burn,Marc S. Greenblatt,Eivind Hovig,Wouter H. de Vos tot Nederveen Cappel,Rolf H. Sijmons,Lucio Bertario,Maria Grazia Tibiletti,Giulia Martina Cavestro,Annika Lindblom,Adriana Della Valle,Francisco López-Köstner,Nathan Gluck,Lior H. Katz,Karl Heinimann,Carlos A. Vaccaro,Reinhard Büttner,Heike Görgens,Elke Holinski-Feder,Monika Morak,Stefanie Holzapfel,Robert Hüneburg,Magnus von Knebel Doeberitz,Magnus von Knebel Doeberitz,Markus Loeffler,Nils Rahner,Hans K. Schackert,Verena Steinke-Lange,Wolff Schmiegel,Deepak Vangala,Kirsi Pylvänäinen,Laura Renkonen-Sinisalo,Laura Renkonen-Sinisalo,John L. Hopper,Aung Ko Win,Robert W. Haile,Noralane M. Lindor,Steven Gallinger,Loic Le Marchand,Polly A. Newcomb,Jane C. Figueiredo,Stephen N. Thibodeau,Karin Wadt,Christina Therkildsen,Henrik Okkels,Zohreh Ketabi,Leticia Moreira,Ariadna Sánchez,Miquel Serra-Burriel,Marta Pineda,Matilde Navarro,Ignacio Blanco,Kate Green,Fiona Lalloo,Emma J Crosbie,James Hill,Oliver G. Denton,Ian M. Frayling,Einar Andreas Rødland,Hans F. A. Vasen,Miriam Mints,Florencia Neffa,Patricia Esperon,Karin Alvarez,Revital Kariv,Guy Rosner,Tamara Alejandra Piñero,María Laura Gonzalez,Pablo Kalfayan,Douglas Tjandra,Ingrid Winship,Ingrid Winship,Finlay A. Macrae,Finlay A. Macrae,Gabriela Möslein,Jukka-Pekka Mecklin,Maartje Nielsen,Pål Møller,Pål Møller +94 more
TL;DR: Management guidelines for Lynch syndrome may require revision in light of these different gene and gender-specific risks and the good prognosis for the most commonly associated cancers.
Journal ArticleDOI
Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
Mev Dominguez-Valentin,Emma J Crosbie,Christoph Engel,Stefan Aretz,Stefan Aretz,Finlay A. Macrae,Finlay A. Macrae,Ingrid Winship,Ingrid Winship,Gabriel Capellá,Huw Thomas,Sigve Nakken,Eivind Hovig,Maartje Nielsen,Rolf H. Sijmons,Lucio Bertario,Bernardo Bonanni,Maria Grazia Tibiletti,Giulia Martina Cavestro,Miriam Mints,Nathan Gluck,Lior H. Katz,Karl Heinimann,Carlos A. Vaccaro,Kate Green,Fiona Lalloo,James Hill,Wolff Schmiegel,Deepak Vangala,Claudia Perne,Claudia Perne,Hans Georg Strauß,Johanna Tecklenburg,Elke Holinski-Feder,Verena Steinke-Lange,Jukka-Pekka Mecklin,John-Paul Plazzer,Marta Pineda,Matilde Navarro,Joan Vidal,Revital Kariv,Guy Rosner,Tamara Alejandra Piñero,María Laura Gonzalez,Pablo Kalfayan,Neil A J Ryan,Sanne W. ten Broeke,Mark A. Jenkins,Lone Sunde,Lone Sunde,Inge Bernstein,John Burn,Marc S. Greenblatt,Wouter H. de Vos tot Nederveen Cappel,Adriana Della Valle,Francisco Lopez-Koestner,Karin Alvarez,Reinhard Büttner,Heike Görgens,Monika Morak,Stefanie Holzapfel,Robert Hüneburg,Magnus von Knebel Doeberitz,Magnus von Knebel Doeberitz,Markus Loeffler,Nils Rahner,Jürgen Weitz,Kirsi Pylvänäinen,Laura Renkonen-Sinisalo,Anna Lepistö,Annika Auranen,John L. Hopper,Aung Ko Win,Robert W. Haile,Noralane M. Lindor,Steven Gallinger,Loic Le Marchand,Polly A. Newcomb,Jane C. Figueiredo,Stephen N. Thibodeau,Christina Therkildsen,Henrik Okkels,Zohreh Ketabi,Oliver G. Denton,Einar Andreas Rødland,Hans F. A. Vasen,Florencia Neffa,Patricia Esperon,Douglas Tjandra,Douglas Tjandra,Gabriela Möslein,Julian R. Sampson,D. Gareth Evans,D. Gareth Evans,Toni T. Seppälä,Toni T. Seppälä,Pål Møller +96 more
TL;DR: Findings may aid decision making for women with LS who are considering RRS and little benefit is gained by performing RRS before 40 years of age and premenopausal BSO in path_MSH6 and path_PMS2 heterozygotes has no measurable benefit for mortality.
Journal ArticleDOI
Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
Toni T. Seppälä,Mev Dominguez-Valentin,Emma J Crosbie,Christoph Engel,Stefan Aretz,Finlay A. Macrae,Finlay A. Macrae,Ingrid Winship,Ingrid Winship,Gabriel Capellá,Huw Thomas,Eivind Hovig,Maartje Nielsen,Rolf H. Sijmons,Lucio Bertario,Bernardo Bonanni,Maria Grazia Tibiletti,Giulia Martina Cavestro,Miriam Mints,Nathan Gluck,Nathan Gluck,Lior H. Katz,Karl Heinimann,Carlos A. Vaccaro,Kate Green,Fiona Lalloo,James Hill,Wolff Schmiegel,Deepak Vangala,Claudia Perne,Hans Georg Strauß,Johanna Tecklenburg,Elke Holinski-Feder,Verena Steinke-Lange,Jukka-Pekka Mecklin,John-Paul Plazzer,Marta Pineda,Matilde Navarro,Joan B. Vida,Revital Kariv,Guy Rosner,Tamara Alejandra Piñero,Walter Hernán Pavicic,Pablo Kalfayan,Sanne W. ten Broeke,Mark A. Jenkins,Lone Sunde,Inge Bernstein,John Burn,Marc S. Greenblatt,Wouter H. de Vos tot Nederveen Cappel,Adriana Della Valle,Francisco Lopez-Koestner,Karin Alvarez,Reinhard Büttner,Heike Görgens,Monika Morak,Stefanie Holzapfel,Robert Hüneburg,Magnus von Knebel Doeberitz,Markus Loeffler,Silke Redler,Jürgen Weitz,Kirsi Pylvänäinen,Laura Renkonen-Sinisalo,Anna Lepistö,John L. Hopper,Aung Ko Win,Noralane M. Lindor,Steven Gallinger,Loic Le Marchand,Polly A. Newcomb,Jane C. Figueiredo,Stephen N. Thibodeau,Christina Therkildsen,Karin Wadt,Marian J.E. Mourits,Zohreh Ketabi,Oliver G. Denton,Einar Andreas Rødland,Hans F. A. Vasen,Florencia Neffa,Patricia Esperon,Douglas Tjandra,Gabriela Möslein,Erik Rokkones,Julian R. Sampson,D. G. Evans,Pål Møller +88 more
TL;DR: In this article, the authors report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants.
Journal ArticleDOI
Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database (Genetics in Medicine, (2020), 22, 1, (15-25), 10.1038/s41436-019-0596-9)
Mev Dominguez-Valentin,Julian R. Sampson,Toni T. Seppälä,Sanne W. ten Broeke,John-Paul Plazzer,Sigve Nakken,Christoph Engel,Stefan Aretz,Mark A. Jenkins,Lone Sunde,Inge Bernstein,Gabriel Capellá,Francesc Balaguer,Huw Thomas,D. Gareth Evans,John Burn,Marc S. Greenblatt,Eivind Hovig,Wouter H. de Vos tot Nederveen Cappel,Rolf H. Sijmons,Lucio Bertario,Maria Grazia Tibiletti,Giulia Martina Cavestro,Annika Lindblom,Adriana Della Valle,Francisco López-Köstner,Nathan Gluck,Lior H. Katz,Karl Heinimann,Carlos A. Vaccaro,Reinhard Büttner,Heike Görgens,Elke Holinski-Feder,Monika Morak,Stefanie Holzapfel,Robert Hüneburg,Magnus von Knebel Doeberitz,Magnus von Knebel Doeberitz,Markus Loeffler,Nils Rahner,Hans K. Schackert,Verena Steinke-Lange,Wolff Schmiegel,Deepak Vangala,Kirsi Pylvänäinen,Laura Renkonen-Sinisalo,John L. Hopper,Aung Ko Win,Robert W. Haile,Noralane M. Lindor,Steven Gallinger,Loic Le Marchand,Polly A. Newcomb,Jane C. Figueiredo,Stephen N. Thibodeau,Karin Wadt,Christina Therkildsen,Henrik Okkels,Zohreh Ketabi,Leticia Moreira,Ariadna Sánchez,Miquel Serra-Burriel,Marta Pineda,Matilde Navarro,Ignacio Blanco,Kate Green,Fiona Lalloo,Emma J Crosbie,James Hill,Oliver G. Denton,Ian M. Frayling,Einar Andreas Rødland,Hans F. A. Vasen,Miriam Mints,Florencia Neffa,Patricia Esperon,Karin Alvarez,Revital Kariv,Guy Rosner,Tamara Alejandra Piñero,María Laura Gonzalez,Pablo Kalfayan,Douglas Tjandra,Ingrid Winship,Ingrid Winship,Finlay A. Macrae,Finlay A. Macrae,Gabriela Möslein,Jukka-Pekka Mecklin,Maartje Nielsen,Pål Møller +90 more
TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Journal ArticleDOI
Validation of the novel Deep Reality Viewer (DRV) 3D digital stereo viewer in otology surgery
TL;DR: In this paper , the Deep Reality Viewer (DRV) was evaluated in the field of otology surgery and compared to both a 2D monitor and the gold standard of microscopy.