J
Jason G. Cyster
Researcher at University of California, San Francisco
Publications - 214
Citations - 46949
Jason G. Cyster is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: B cell & Germinal center. The author has an hindex of 106, co-authored 199 publications receiving 42370 citations. Previous affiliations of Jason G. Cyster include London Research Institute & Howard Hughes Medical Institute.
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Journal ArticleDOI
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Mehrdad Matloubian,Charles G. Lo,Guy Cinamon,Matthew J. Lesneski,Ying Xu,Volker Brinkmann,Maria L. Allende,Richard L. Proia,Jason G. Cyster +8 more
TL;DR: It is established that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs.
Journal ArticleDOI
A chemokine-driven positive feedback loop organizes lymphoid follicles
K M Ansel,Vu N. Ngo,P. L. Hyman,Sanjiv A. Luther,Reinhold Förster,Jonathon D. Sedgwick,Jeffrey L. Browning,Martin Lipp,Jason G. Cyster +8 more
TL;DR: It is established that B-lymphocyte chemoattractant (BLC/BCA1) and its receptor, CXCR5, are needed for B-cell homing to follicles in lymph nodes as well as in spleen, and that BLC is required for the development of most lymph nodes and Peyer's patches.
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Chemokines and Cell Migration in Secondary Lymphoid Organs
TL;DR: Current understanding of the roles played by chemokines in the functional biology of secondary lymphoid organs will be reviewed and a central role for the chemokine family of molecules has been uncovered.
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CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
Lawrence R. Shiow,David B. Rosen,Naděžda Brdičková,Ying Xu,Jinping An,Lewis L. Lanier,Jason G. Cyster,Mehrdad Matloubian +7 more
TL;DR: Treatment with the IFN-α/β inducer polyinosine polycytidylic acid inhibited egress by a mechanism that was partly lymphocyte-intrinsic, and observations indicate that CD69 forms a complex with and negatively regulates S1P1 and that it functions downstream ofIFN- α/β, and possibly other activating stimuli, to promote lymphocyte retention in lymphoid organs.
Journal ArticleDOI
A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
Michael D. Gunn,Kirsten Tangemann,Carmen Tam,Jason G. Cyster,Steven D. Rosen,Lewis T. Williams +5 more
TL;DR: SLC is the first chemokine demonstrated to have the characteristics required to mediate homing of lymphocytes to secondary lymphoid organs and the expression of SLC in lymphatic endothelium suggests that the migration of lymphocyte from tissues into efferent lymphatics may be an active process mediated by this molecule.