Journal ArticleDOI
Chemokines and Cell Migration in Secondary Lymphoid Organs
TLDR
Current understanding of the roles played by chemokines in the functional biology of secondary lymphoid organs will be reviewed and a central role for the chemokine family of molecules has been uncovered.Abstract:
As few as one in 100,000 B and T lymphocytes are specific for a single protein antigen, such as tetanus toxin, yet these cells must come together if an antibody response is to occur. Bringing antigen-presenting cells and rare antigen-specific B and T lymphocytes into physical contact is a principal function of secondary lymphoid organs. In the last few years, details have begun to emerge on the cues that guide cell movements inside lymphoid organs, and a central role for the chemokine family of molecules has been uncovered. Here, current understanding of the roles played by chemokines in the functional biology of secondary lymphoid organs will be reviewed.read more
Citations
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Journal ArticleDOI
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
Lin Zhang,Jose R. Conejo-Garcia,Dionyssios Katsaros,Phyllis A. Gimotty,Marco Massobrio,Giorgia Regnani,Antonis Makrigiannakis,Heidi J. Gray,Katia Schlienger,Michael N. Liebman,Stephen C. Rubin,George Coukos +11 more
TL;DR: The presence of intratumoral T cells correlates with improved clinical outcome in advanced ovarian carcinoma and was associated with increased expression of interferon-gamma, interleukin-2, and lymphocyte-attracting chemokines within the tumor.
Journal ArticleDOI
The Many Roles of Chemokines and Chemokine Receptors in Inflammation
TL;DR: The properties of chemokines and their receptors are discussed and the roles of these chemoattractants in selected clinical disorders are highlighted.
Journal Article
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Philip M. Murphy,Marco Baggiolini,Israel F. Charo,Caroline A. Hébert,Richard Horuk,Kouji Matsushima,Louis H. Miller,Joost J. Oppenheim,Christine A. Power +8 more
TL;DR: A widely accepted receptor nomenclature system is described, ratified by the International Union of Pharmacology, that is facilitating clear communication in this area and updating current concepts of the biology and pharmacology of the chemokine system.
Journal ArticleDOI
Human mesenchymal stem cells modulate B-cell functions
Anna Corcione,Federica Benvenuto,Elisa Ferretti,Debora Giunti,Valentina Cappiello,Francesco Cazzanti,Marco Risso,Francesca Gualandi,Giovanni Luigi Mancardi,Vito Pistoia,Antonio Uccelli +10 more
TL;DR: The results further support the potential therapeutic use of hMSCs in immune-mediated disorders, including those in which B cells play a major role.
Journal ArticleDOI
T-cell function and migration. Two sides of the same coin.
TL;DR: This review will concentrate on the migration of T cells, which are at the heart of most adaptive immune responses, since T cells respond to pathogens only on direct contact with pathogen-derived antigen.
References
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Journal ArticleDOI
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