J
Jianming Jiang
Researcher at National University of Singapore
Publications - 28
Citations - 6426
Jianming Jiang is an academic researcher from National University of Singapore. The author has contributed to research in topics: Induced pluripotent stem cell & Homeobox protein NANOG. The author has an hindex of 18, co-authored 27 publications receiving 5910 citations. Previous affiliations of Jianming Jiang include Peking Union Medical College & University Health System.
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Journal ArticleDOI
Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells
Xi Chen,Han Xu,Ping Yuan,Fang Fang,Fang Fang,Mikael Huss,Vinsensius B. Vega,Eleanor Wong,Yuriy L. Orlov,Weiwei Zhang,Weiwei Zhang,Jianming Jiang,Jianming Jiang,Yuin-Han Loh,Yuin-Han Loh,Hock Chuan Yeo,Zhen Xuan Yeo,Vipin Narang,Kunde R Govindarajan,Bernard Leong,Atif Shahab,Yijun Ruan,Guillaume Bourque,Wing-Kin Sung,Neil D. Clarke,Chia-Lin Wei,Huck-Hui Ng,Huck-Hui Ng +27 more
TL;DR: This study uses chromatin immunoprecipitation coupled with ultra-high-throughput DNA sequencing to map the locations of TF-binding sites and identifies important features of the transcriptional regulatory networks that define ES-cell identity.
Journal ArticleDOI
De novo mutations in histone-modifying genes in congenital heart disease
Samir Zaidi,Murim Choi,Hiroko Wakimoto,Lijiang Ma,Jianming Jiang,John D. Overton,Angela Romano-Adesman,Robert D. Bjornson,Roger E. Breitbart,Kerry K. Brown,Nicholas Carriero,Yee Him Cheung,John E. Deanfield,Steve Depalma,Khalid Adnan Mohamed A. Fakhro,Joseph T. Glessner,Hakon Hakonarson,Michael J. Italia,Jonathan R. Kaltman,Juan Pablo Kaski,Richard B. Kim,Jennie Kline,Teresa Lee,Jeremy Leipzig,Alexander Lopez,Shrikant Mane,Laura E. Mitchell,Jane W. Newburger,Michael Parfenov,Itsik Pe'er,George A. Porter,Amy E. Roberts,Ravi Sachidanandam,Stephen Sanders,Howard S. Seiden,Mathew W. State,Sai Lakshmi Subramanian,Irina Tikhonova,Wei Wang,Wei Wang,Dorothy Warburton,Peter White,Ismee A. Williams,Hongyu Zhao,Jonathan G. Seidman,Martina Brueckner,Wendy K. Chung,Bruce D. Gelb,Elizabeth Goldmuntz,Christine E. Seidman,Richard P. Lifton +50 more
TL;DR: Comparing the incidence of de novo mutations in severe CHD cases and controls by analysing exome sequencing of parent–offspring trios suggests that several hundreds of genes collectively contribute to approximately 10% of severeCHD.
Journal ArticleDOI
A core Klf circuitry regulates self-renewal of embryonic stem cells
Jianming Jiang,Yun-Shen Chan,Yun-Shen Chan,Yuin-Han Loh,Yuin-Han Loh,Jun Cai,Guo-Qing Tong,Guo-Qing Tong,Ching-Aeng Lim,Ching-Aeng Lim,Paul Robson,Paul Robson,Sheng Zhong,Huck-Hui Ng,Huck-Hui Ng +14 more
TL;DR: This study provides new insight into how the core Klf circuitry integrates into the Nanog transcriptional network to specify gene expression that is unique to ES cells.
Journal ArticleDOI
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb
Bo Feng,Jianming Jiang,Jianming Jiang,Petra Kraus,Jia-Hui Ng,Jian-Chien Dominic Heng,Jian-Chien Dominic Heng,Yun-Shen Chan,Yun-Shen Chan,Lai-Ping Yaw,Weiwei Zhang,Weiwei Zhang,Yuin-Han Loh,Yuin-Han Loh,Jianyong Han,Vinsensius B. Vega,Valere Cacheux-Rataboul,Bing Lim,Bing Lim,Thomas Lufkin,Huck-Hui Ng,Huck-Hui Ng +21 more
TL;DR: This work shows that the orphan nuclear receptor Esrrb functions in conjunction with Oct4 and Sox2 to mediate reprogramming of mouse embryonic fibroblasts (MEFs) to iPS cells, and indicates that it is possible to reprogram MEFs without exogenous Klf transcription factors and link a nuclear receptor to somatic cell reprograming.
Journal ArticleDOI
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.
Jian-Chien Dominic Heng,Bo Feng,Jianyong Han,Jianming Jiang,Petra Kraus,Jia-Hui Ng,Yuriy L. Orlov,Mikael Huss,Lin Yang,Thomas Lufkin,Thomas Lufkin,Bing Lim,Bing Lim,Huck-Hui Ng,Huck-Hui Ng +14 more
TL;DR: It is shown that the orphan nuclear receptor Nr5a2 (also known as Lrh-1) can replace Oct4 in the derivation of iPSCs from mouse somatic cells, and it can also enhance reprogramming efficiency.