다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

https://www.massey.ac.nz/~ychisti/Biodiesel.pdf

Biodiesel from microalgae.

https://www.cti2000.it/Bionett/BioD-1999-101%20Biodiesel%20production%20review.pdf

Biodiesel production : a review

Interferon-gamma (IFN-gamma) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN-gamma ligand, receptor, signal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophage function during infection. The current model for IFN-gamma signal transduction is discussed, as well as signal regulation and factors conferring signal specificity. Cellular effects of IFN-gamma are described, including up-regulation of pathogen recognition, antigen processing and presentation, the antiviral state, inhibition of cellular proliferation and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking. In addition, integration of signaling and response with other cytokines and pathogen-associated molecular patterns, such as tumor necrosis factor-alpha, interleukin-4, type I IFNs, and lipopolysaccharide are discussed.

https://jlb.onlinelibrary.wiley.com/doi/epdf/10.1189/jlb.0603252

Interferon-γ: an overview of signals, mechanisms and functions

Microalgae represent an exceptionally diverse but highly specialized group of micro-organisms adapted to various ecological habitats. Many microalgae have the ability to produce substantial amounts (e.g. 20-50% dry cell weight) of triacylglycerols (TAG) as a storage lipid under photo-oxidative stress or other adverse environmental conditions. Fatty acids, the building blocks for TAGs and all other cellular lipids, are synthesized in the chloroplast using a single set of enzymes, of which acetyl CoA carboxylase (ACCase) is key in regulating fatty acid synthesis rates. However, the expression of genes involved in fatty acid synthesis is poorly understood in microalgae. Synthesis and sequestration of TAG into cytosolic lipid bodies appear to be a protective mechanism by which algal cells cope with stress conditions, but little is known about regulation of TAG formation at the molecular and cellular level. While the concept of using microalgae as an alternative and renewable source of lipid-rich biomass feedstock for biofuels has been explored over the past few decades, a scalable, commercially viable system has yet to emerge. Today, the production of algal oil is primarily confined to high-value specialty oils with nutritional value, rather than commodity oils for biofuel. This review provides a brief summary of the current knowledge on oleaginous algae and their fatty acid and TAG biosynthesis, algal model systems and genomic approaches to a better understanding of TAG production, and a historical perspective and path forward for microalgae-based biofuel research and commercialization.

https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1365-313X.2008.03492.x

Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances

A prospective study of infants under 1 y of age, ventilated for severe viral bronchiolitis, was carried out in four paediatric intensive care units in order to study surfactant activity and composition in this condition. Lung lavage fluid from 24 infants with bronchiolitis, 19 with bronchiolitis and sepsis or cardiac failure and 12 controls were analysed by the “click test” for surfactant activity and for phospholipids. Surfactant activity was present in all controls, but in only 2 of the 24 infants with bronchiolitis alone. The presence of phosphatidylglycerol correlated perfectly with the click test, suggesting that reduced activity is due to changes in surfactant lipid composition. In those with bronchiolitis plus coexisting disease, surfactant activity and phosphatidylglycerol were absent in only half. Surfactant activity and phosphatidylglycerol re-appeared by extubation. Severe viral bronchiolitis is associated with an absence of surfactant activity and PG, which resolves by clinical recovery. Infants with coexisting conditions are not always surfactant deficient. Surfactant administration is likely to be beneficial, but requires a selective approach. □Bronchiolitis, lung surfactant, phosphatidylglycerol

Abnormal surfactant composition and activity in severe bronchiolitis.

Lipids are one of the major subcellular components, and play numerous essential functions. As well as their physiological roles, oils stored in biomass are useful commodities for a variety of biotechnological applications including food, chemical feedstocks, and fuel. Due to their agronomic as well as economic and societal importance, lipids have historically been subjected to intensive studies. Major current efforts are to increase the energy density of cell biomass, and/or create designer oils suitable for specific applications. This chapter covers some basic aspects of what one needs to know about lipids: definition, structure, function, metabolism and focus is also given on the development of modern lipid analytical tools and major current engineering approaches for biotechnological applications. This introductory chapter is intended to serve as a primer for all subsequent chapters in this book outlining current development in specific areas of lipids and their metabolism.

Lipids: From Chemical Structures, Biosynthesis, and Analyses to Industrial Applications

When [14C]diacylgalactosylglycerol was added to isolated pea or lettuce chloroplasts linolenate synthesis was seen. The desaturation of [14C]linoleate in diacylgalactosylglycerol to [14C]linolenate was stimulated by the addition of a soluble protein fraction containing lipid-exchange activity. Other [14C]acyl lipids were ineffective, except that [14C]phosphatidylcholine in the presence of UDP-galactose and sn-glycerol 3-phosphate could also supply [14C]linoleate for desaturation. These results are consistent with a role of diacylgalactosylglycerol in linolenate synthesis, as indirectly suggested by labelling experiments.

Desaturation of linoleic acid from exogenous lipids by isolated chloroplasts.

Lipid synthesis by germinating soya bean

Lipid metabolism and environmental effects on this process have been studied in the marine brown algae Fucus vesiculosus and Ascophyllum nodosum. These algae showed very similar patterns of lipid metabolism during 24 h incubations. Labelling from [1-C-14]acetate showed the major labelled lipids to be the beta-alanine ether lipid and the neutral lipid fraction in both algae. Of the glycolipids, only sulphoquinovosyldiacylglycerol was well labelled and the phosphoglycerides were all poorly labelled. The major labelled fatty acids were palmitate and oleate, again in both algae, although Fucus vesiculosus also showed significant labelling of stearate and behenate. Although the amount of fatty acid labelling increased with time, the proportion of label in palmitate and oleate remained approximately constant. Very long chain fatty acids (arachidic, behenic) were increasingly labelled with time. Lowered incubation temperatures decreased labelling of the saturated fatty acids. Cu2+ increased the proportion of oleate labelled in both algae, and of linoleate in Fucus vesiculosus. This cation decreased the percentage labelling of stearate and myristate in Ascophyllum nodosum. Lipid metabolism in Ascophyllum nodosum was more sensitive to raised Cu2+ levels than in Fucus vesiculosus.

John L. Harwood

Papers

Abnormal surfactant composition and activity in severe bronchiolitis.

Lipids: From Chemical Structures, Biosynthesis, and Analyses to Industrial Applications

Desaturation of linoleic acid from exogenous lipids by isolated chloroplasts.

Lipid synthesis by germinating soya bean

Lipid Metabolism in the Brown Marine Algae Fucus vesiculosus and Ascophyllum nodosum