Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Heribert Schunkert,Inke R. König,Sekar Kathiresan,Muredach P. Reilly,Themistocles L. Assimes,Hilma Holm,Michael Preuss,Alexandre F.R. Stewart,Maja Barbalić,Christian Gieger,Devin Absher,Zouhair Aherrahrou,Hooman Allayee,David Altshuler,Sonia S. Anand,Karl Andersen,Jeffrey L. Anderson,Diego Ardissino,Stephen G. Ball,Anthony J. Balmforth,Timothy A. Barnes,Diane M. Becker,Lewis C. Becker,Klaus Berger,Joshua C. Bis,S. Matthijs Boekholdt,Eric Boerwinkle,Peter S. Braund,Morris J. Brown,Mary Susan Burnett,Ian Buysschaert,John F. Carlquist,Li Chen,Sven Cichon,Veryan Codd,Robert W. Davies,George Dedoussis,Abbas Dehghan,Serkalem Demissie,Joseph M. Devaney,Patrick Diemert,Ron Do,Angela Doering,Sandra Eifert,Nour Eddine El Mokhtari,Stephen G. Ellis,Roberto Elosua,James C. Engert,Stephen E. Epstein,Ulf de Faire,Marcus Fischer,Aaron R. Folsom,Jennifer Freyer,Bruna Gigante,Domenico Girelli,Solveig Gretarsdottir,Vilmundur Gudnason,Jeffrey R. Gulcher,Eran Halperin,Naomi Hammond,Stanley L. Hazen,Albert Hofman,Benjamin D. Horne,Thomas Illig,Carlos Iribarren,Gregory T. Jones,J. Wouter Jukema,Michael A. Kaiser,Lee M. Kaplan,John J.P. Kastelein,Kay-Tee Khaw,Joshua W. Knowles,G. Kolovou,Augustine Kong,Reijo Laaksonen,Diether Lambrechts,Karin Leander,Guillaume Lettre,Mingyao Li,Wolfgang Lieb,Christina Loley,Andrew J. Lotery,Pier Mannuccio Mannucci,Seraya Maouche,Nicola Martinelli,Pascal P. McKeown,Christa Meisinger,Thomas Meitinger,Olle Melander,Pier Angelica Merlini,Vincent Mooser,Thomas M. Morgan,Thomas W. Mühleisen,Joseph B. Muhlestein,Thomas Münzel,Kiran Musunuru,Janja Nahrstaedt,Christopher P. Nelson,Markus M. Nöthen,Oliviero Olivieri,Riyaz S. Patel,Christopher Patterson,Annette Peters,Flora Peyvandi,Liming Qu,Arshed A. Quyyumi,Daniel J. Rader,Loukianos S. Rallidis,Catherine M. Rice,Frits R. Rosendaal,Diana Rubin,Veikko Salomaa,M. Lourdes Sampietro,M. S. Sandhu,Eric E. Schadt,Arne Scḧsignfer,Arne Schillert,Stefan Schreiber,Jürgen Schrezenmeir,Stephen M. Schwartz,David S. Siscovick,Mohan U. Sivananthan,Suthesh Sivapalaratnam,Albert V. Smith,Tamara B. Smith,Jaapjan D. Snoep,Nicole Soranzo,John A. Spertus,Klaus Stark,Kathy Stirrups,Monika Stoll,W.H. Wilson Tang,Stephanie Tennstedt,Gudmundur Thorgeirsson,Gudmar Thorleifsson,Maciej Tomaszewski,André G. Uitterlinden,Andre M. van Rij,Benjamin F. Voight,Nicholas J. Wareham,George A. Wells,H.-Erich Wichmann,Philipp S. Wild,Christina Willenborg,Jaqueline C M Witteman,Benjamin J. Wright,Shu Ye,Tanja Zeller,Andreas Ziegler,François Cambien,Alison H. Goodall,L. Adrienne Cupples,Thomas Quertermous,Winfried Mäsignrz,Christian Hengstenberg,Stefan Blankenberg,Willem H. Ouwehand,Alistair S. Hall,Panos Deloukas,John R. Thompson,Kari Stefansson,Robert Roberts,Unnur Thorsteinsdottir,Christopher J. O'Donnell,Ruth McPherson,Jeanette Erdmann,Nilesh J. Samani +166 more
TLDR
This paper performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals.Abstract:
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 - 10'8 and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.read more
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Heart Disease and Stroke Statistics—2013 Update A Report From the American Heart Association
Alan S. Go,Dariush Mozaffarian,Véronique L. Roger,Emelia J. Benjamin,Jarett D. Berry,William B. Borden,Dawn M. Bravata,Shifan Dai,Earl S. Ford,Caroline S. Fox,Sheila Franco,Heather J. Fullerton,Cathleen Gillespie,Susan M. Hailpern,John A. Heit,Virginia J. Howard,Mark D. Huffman,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,David J. Magid,Gregory M. Marcus,Ariane Marelli,David B. Matchar,Darren K. McGuire,Emile R. Mohler,Claudia S. Moy,Michael E. Mussolino,Graham Nichol,Nina P. Paynter,Pamela J. Schreiner,Paul D. Sorlie,Joel Stein,Tanya N. Turan,Salim S. Virani,Nathan D. Wong,Daniel Woo,Melanie B. Turner +39 more
TL;DR: Author(s): Go, Alan S; Mozaffarian, Dariush; Roger, Veronique L; Benjamin, Emelia J; Berry, Jarett D; Borden, William B; Bravata, Dawn M; Dai, Shifan; Ford, Earl S; Fox, Caroline S; Franco, Sheila; Fullerton, Heather J; Gillespie, Cathleen; Hailpern, Susan M; Heit, John A; Howard, Virginia J; Huff
Journal ArticleDOI
Heart Disease and Stroke Statistics—2012 Update A Report From the American Heart Association
Véronique L. Roger,Alan S. Go,Donald M. Lloyd-Jones,Emelia J. Benjamin,Jarett D. Berry,William B. Borden,Dawn M. Bravata,Shifan Dai,Earl S. Ford,Caroline S. Fox,Heather J. Fullerton,Cathleen Gillespie,Susan M. Hailpern,John A. Heit,Virginia J. Howard,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,Diane M. Makuc,Gregory M. Marcus,Ariane Marelli,David B. Matchar,Claudia S. Moy,Dariush Mozaffarian,Michael E. Mussolino,Graham Nichol,Nina P. Paynter,Elsayed Z. Soliman,Paul D. Sorlie,Nona Sotoodehnia,Tanya N. Turan,Salim S. Virani,Nathan D. Wong,Daniel Woo,Melanie B. Turner +36 more
TL;DR: The American Heart Association's 2020 Impact Goals for Cardiovascular Diseases and Disorders are revealed, with a focus on preventing, treating, and preventing heart disease and stroke.
Journal ArticleDOI
LD score regression distinguishes confounding from polygenicity in genome-wide association studies :
Brendan Bulik-Sullivan,Po-Ru Loh,Hilary K. Finucane,Stephan Ripke,Jian Yang,Nick Patterson,Mark J. Daly,Alkes L. Price,Benjamin M. Neale +8 more
TL;DR: It is found that polygenicity accounts for the majority of the inflation in test statistics in many GWAS of large sample size, and the LD Score regression intercept can be used to estimate a more powerful and accurate correction factor than genomic control.
Journal ArticleDOI
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
TL;DR: An adaption of Egger regression can detect some violations of the standard instrumental variable assumptions, and provide an effect estimate which is not subject to these violations, and provides a sensitivity analysis for the robustness of the findings from a Mendelian randomization investigation.
Journal ArticleDOI
The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Danielle Welter,Jacqueline A. L. MacArthur,Joannella Morales,Tony Burdett,Peggy Hall,Heather Junkins,Alan Klemm,Paul Flicek,Teri A. Manolio,Lucia A. Hindorff,Helen Parkinson +10 more
TL;DR: A number of recent improvements to theNHGRI Catalog of Published Genome-Wide Association Studies are presented, including novel ways for users to interact with the Catalog and changes to the curation infrastructure.
References
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
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TL;DR: This paper examined potential sources of missing heritability and proposed research strategies, including and extending beyond current genome-wide association approaches, to illuminate the genetics of complex diseases and enhance its potential to enable effective disease prevention or treatment.
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Heart Disease and Stroke Statistics—2010 Update A Report From the American Heart Association
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A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
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