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Karol Nass
Researcher at Paul Scherrer Institute
Publications - 83
Citations - 8229
Karol Nass is an academic researcher from Paul Scherrer Institute. The author has contributed to research in topics: Femtosecond & Laser. The author has an hindex of 32, co-authored 74 publications receiving 7116 citations. Previous affiliations of Karol Nass include Max Planck Society & University of Hamburg.
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Journal ArticleDOI
Femtosecond X-ray protein nanocrystallography
Henry N. Chapman,Petra Fromme,Anton Barty,Thomas A. White,Richard A. Kirian,Andrew Aquila,Mark S. Hunter,Joachim Schulz,Daniel P. DePonte,Uwe Weierstall,R. Bruce Doak,Filipe R. N. C. Maia,Andrew V. Martin,Ilme Schlichting,Lukas Lomb,Nicola Coppola,Robert L. Shoeman,Sascha W. Epp,Robert Hartmann,Daniel Rolles,Artem Rudenko,Lutz Foucar,Nils Kimmel,Georg Weidenspointner,Peter Holl,Mengning Liang,Miriam Barthelmess,Carl Caleman,Sébastien Boutet,Michael J. Bogan,Jacek Krzywinski,Christoph Bostedt,Saša Bajt,Lars Gumprecht,Benedikt Rudek,Benjamin Erk,Carlo Schmidt,André Hömke,Christian Reich,Daniel Pietschner,Lothar Strüder,Günter Hauser,H. Gorke,Joachim Ullrich,Sven Herrmann,Gerhard Schaller,Florian Schopper,Heike Soltau,Kai-Uwe Kühnel,Marc Messerschmidt,John D. Bozek,Stefan P. Hau-Riege,Matthias Frank,Christina Y. Hampton,Raymond G. Sierra,Dmitri Starodub,Garth J. Williams,Janos Hajdu,Nicusor Timneanu,M. Marvin Seibert,M. Marvin Seibert,Jakob Andreasson,Andrea Rocker,Olof Jönsson,Martin Svenda,Stephan Stern,Karol Nass,Robert Andritschke,Claus Dieter Schröter,Faton Krasniqi,Mario Bott,Kevin Schmidt,Xiaoyu Wang,Ingo Grotjohann,James M. Holton,Thomas R. M. Barends,Richard Neutze,Stefano Marchesini,Raimund Fromme,Sebastian Schorb,Daniela Rupp,M. Adolph,Tais Gorkhover,Inger Andersson,Helmut Hirsemann,Guillaume Potdevin,Heinz Graafsma,Björn Nilsson,John C. H. Spence +88 more
TL;DR: This work offers a new approach to structure determination of macromolecules that do not yield crystals of sufficient size for studies using conventional radiation sources or are particularly sensitive to radiation damage, by using pulses briefer than the timescale of most damage processes.
Journal ArticleDOI
High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography
Sébastien Boutet,Lukas Lomb,Garth J. Williams,Thomas R. M. Barends,Andrew Aquila,R. Bruce Doak,Uwe Weierstall,Daniel P. DePonte,Jan Steinbrener,Robert L. Shoeman,Marc Messerschmidt,Anton Barty,Thomas A. White,Stephan Kassemeyer,Richard A. Kirian,M. Marvin Seibert,Paul A. Montanez,C.J. Kenney,Ryan Herbst,P. Hart,J. Pines,Gunther Haller,Sol M. Gruner,Hugh T. Philipp,Mark W. Tate,Marianne Hromalik,Lucas J. Koerner,Niels van Bakel,John Morse,W. Ghonsalves,David Arnlund,Michael J. Bogan,Carl Caleman,Raimund Fromme,Christina Y. Hampton,Mark S. Hunter,Linda C. Johansson,Gergely Katona,Christopher Kupitz,Mengning Liang,Andrew V. Martin,Karol Nass,Lars Redecke,Lars Redecke,Francesco Stellato,Nicusor Timneanu,Dingjie Wang,Nadia A. Zatsepin,Donald W. Schafer,James Defever,Richard Neutze,Petra Fromme,John C. H. Spence,Henry N. Chapman,Ilme Schlichting +54 more
TL;DR: Serial femtosecond crystallography (SFX) is applied using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals of the well-characterized model protein lysozyme, demonstrating the immediate relevance of SFX for analyzing the structure of the large group of difficult-to-crystallize molecules.
Journal ArticleDOI
Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser
Lars Redecke,Lars Redecke,Karol Nass,Daniel P. DePonte,Thomas A. White,Dirk Rehders,Anton Barty,Francesco Stellato,Mengning Liang,Thomas R. M. Barends,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,M. Marvin Seibert,Andrew Aquila,David Arnlund,Saša Bajt,Torsten Barth,Michael J. Bogan,Carl Caleman,Tzu-Chiao Chao,R. Bruce Doak,Holger Fleckenstein,Matthias Frank,Raimund Fromme,Lorenzo Galli,Ingo Grotjohann,Mark S. Hunter,Linda C. Johansson,Stephan Kassemeyer,Gergely Katona,Richard A. Kirian,Rudolf Koopmann,Chris Kupitz,Lukas Lomb,Andrew V. Martin,Stefan Mogk,Richard Neutze,Robert L. Shoeman,Jan Steinbrener,Nicusor Timneanu,Dingjie Wang,Uwe Weierstall,Nadia A. Zatsepin,John C. H. Spence,Petra Fromme,Ilme Schlichting,Michael Duszenko,Christian Betzel,Henry N. Chapman +49 more
TL;DR: The structure reveals the mechanism of native TbCatB inhibition and demonstrates that new biomolecular information can be obtained by the “diffraction-before-destruction” approach of x-ray free-electron lasers from hundreds of thousands of individual microcrystals.
Journal ArticleDOI
Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser.
Christopher Kupitz,Shibom Basu,Ingo Grotjohann,Raimund Fromme,Nadia A. Zatsepin,Kimberly N. Rendek,Mark S. Hunter,Mark S. Hunter,Robert L. Shoeman,Thomas A. White,Dingjie Wang,Daniel James,Jay-How Yang,Danielle E. Cobb,Brenda Reeder,Raymond G. Sierra,Haiguang Liu,Anton Barty,Andrew Aquila,Daniel P. DePonte,Richard A. Kirian,Sadia Bari,Jesse J. Bergkamp,Kenneth R. Beyerlein,Michael J. Bogan,Carl Caleman,Tzu-Chiao Chao,Tzu-Chiao Chao,Chelsie E. Conrad,Katherine M. Davis,Holger Fleckenstein,Lorenzo Galli,Stefan P. Hau-Riege,Stephan Kassemeyer,Hartawan Laksmono,Mengning Liang,Lukas Lomb,Stefano Marchesini,Andrew V. Martin,Marc Messerschmidt,Despina Milathianaki,Karol Nass,Alexandra Ros,Shatabdi Roy-Chowdhury,Kevin Schmidt,M. Marvin Seibert,M. Marvin Seibert,Jan Steinbrener,Francesco Stellato,Lifen Yan,Chun Hong Yoon,Thomas A. Moore,Ana L. Moore,Yulia Pushkar,Garth J. Williams,Sébastien Boutet,R. Bruce Doak,Uwe Weierstall,Matthias Frank,Henry N. Chapman,John C. H. Spence,Petra Fromme +61 more
TL;DR: Time resolved experiments on PSII nano/microcrystals from Thermosynechococcus elongatus performed with the recently developed technique of serial femtosecond crystallography provide evidence that PSII undergoes significant conformational changes at the electron acceptor side and at the Mn4CaO5 core of the OEC.
Journal ArticleDOI
CrystFEL: a software suite for snapshot serial crystallography
Thomas A. White,Richard A. Kirian,Andrew V. Martin,Andrew Aquila,Karol Nass,Anton Barty,Henry N. Chapman +6 more
TL;DR: In order to address the specific needs of the emerging technique of `serial femtosecond crystallography', in which structural information is obtained from small crystals illuminated by an X-ray free-electron laser, a new software suite has been created.