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Katleen De Preter
Researcher at Ghent University
Publications - 161
Citations - 24504
Katleen De Preter is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & Gene. The author has an hindex of 41, co-authored 150 publications receiving 21878 citations. Previous affiliations of Katleen De Preter include Katholieke Universiteit Leuven & Ghent University Hospital.
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Journal ArticleDOI
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
Jo Vandesompele,Katleen De Preter,Filip Pattyn,Bruce Poppe,Nadine Van Roy,Anne De Paepe,Franki Speleman +6 more
TL;DR: The normalization strategy presented here is a prerequisite for accurate RT-PCR expression profiling, which opens up the possibility of studying the biological relevance of small expression differences.
Journal ArticleDOI
Mutational dynamics between primary and relapse neuroblastomas
Alexander Schramm,Johannes Köster,Johannes Köster,Yassen Assenov,Kristina Althoff,Martin Peifer,E Mahlow,Andrea Odersky,Daniela Beisser,Corinna Ernst,Anton G. Henssen,Anton G. Henssen,Anton G. Henssen,Harald Stephan,Christopher Schröder,Lukas C. Heukamp,Anne Engesser,Yvonne Kahlert,Jessica Theissen,Barbara Hero,Frederik Roels,Janine Altmüller,Peter Nürnberg,Kathy Astrahantseff,Christian Gloeckner,Katleen De Preter,Christoph Plass,Sangkyun Lee,Holger N. Lode,Kai Oliver Henrich,Moritz Gartlgruber,Frank Speleman,Peter Schmezer,Frank Westermann,Sven Rahmann,Sven Rahmann,Matthias Fischer,Angelika Eggert,Angelika Eggert,Johannes H. Schulte,Johannes H. Schulte,Johannes H. Schulte +41 more
TL;DR: The mutational burden significantly increased in relapsing tumors, accompanied by altered mutational signatures and reduced subclonal heterogeneity and global allele frequencies at relapse indicated clonal mutation selection during disease progression.
Journal ArticleDOI
Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification
Sara De Brouwer,Katleen De Preter,Candy Kumps,Piotr Zabrocki,Michaël Porcu,Ellen M. Westerhout,Arjan Lakeman,Jo Vandesompele,Jasmien Hoebeeck,Tom Van Maerken,Anne De Paepe,Genevieve Laureys,Johannes H. Schulte,Alexander Schramm,Caroline Van den Broecke,Joëlle Vermeulen,Nadine Van Roy,Klaus Beiske,Marleen Renard,Rosa Noguera,Olivier Delattre,Isabelle Janoueix-Lerosey,Per Kogner,Tommy Martinsson,Akira Nakagawara,Miki Ohira,Huib N. Caron,Angelika Eggert,Jan Cools,Rogier Versteeg,Frank Speleman +30 more
TL;DR: A meta-analysis of 709 neuroblastoma tumors to determine their frequency and mutation spectrum in relation to genomic and clinical parameters, and studied the prognostic significance of ALK copy number and expression found Chromosome 2p gains were associated with a significantly increased ALK expression, which was also correlated with poor survival.
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Evaluation of qPCR curve analysis methods for reliable biomarker discovery: bias, resolution, precision, and implications.
Jan M. Ruijter,Michael W. Pfaffl,Sheng Zhao,Andrej N. Spiess,Gregory J. Boggy,Jochen Blom,Robert G. Rutledge,Davide Sisti,Antoon Lievens,Katleen De Preter,Stefaan Derveaux,Jan Hellemans,Jo Vandesompele +12 more
TL;DR: Developing a framework for robust and unbiased assessment of curve analysis performance whereby various publicly available curve analysis methods were thoroughly compared using a previously published large clinical data set is aimed at.
Journal ArticleDOI
Quantification of MYCN, DDX1, and NAG Gene Copy Number in Neuroblastoma Using a Real-Time Quantitative PCR Assay
Katleen De Preter,Frank Speleman,Valérie Combaret,John Lunec,Genevieve Laureys,Bert H.J. Eussen,Nadine Francotte,Julian Board,Andrew D.J. Pearson,Anne De Paepe,Nadine Van Roy,Jo Vandesompele +11 more
TL;DR: A real-time quantitative PCR assay is developed and evaluated as an alternative for time-consuming Southern blot analysis (SB), and as a second independent technique in parallel with fluorescence in situ hybridization (FISH) analysis, which pointed out that DDX1 and NAG amplification has no additional adverse effect on prognosis.