S
Stuart Cantsilieris
Researcher at University of Washington
Publications - 14
Citations - 1730
Stuart Cantsilieris is an academic researcher from University of Washington. The author has contributed to research in topics: Segmental duplication & Copy-number variation. The author has an hindex of 10, co-authored 14 publications receiving 1147 citations. Previous affiliations of Stuart Cantsilieris include University of Melbourne.
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Journal ArticleDOI
Multi-platform discovery of haplotype-resolved structural variation in human genomes
Mark Chaisson,Mark Chaisson,Ashley D. Sanders,Xuefang Zhao,Xuefang Zhao,Ankit Malhotra,David Porubsky,David Porubsky,Tobias Rausch,Eugene J. Gardner,Oscar L. Rodriguez,Li Guo,Ryan L. Collins,Xian Fan,Jia Wen,Robert E. Handsaker,Robert E. Handsaker,Susan Fairley,Zev N. Kronenberg,Xiangmeng Kong,Fereydoun Hormozdiari,Dillon Lee,Aaron M. Wenger,Alex Hastie,Danny Antaki,Thomas Anantharaman,Peter A. Audano,Harrison Brand,Stuart Cantsilieris,Han Cao,Eliza Cerveira,Chong Chen,Xintong Chen,Chen-Shan Chin,Zechen Chong,Nelson T. Chuang,Christine C. Lambert,Deanna M. Church,Laura Clarke,Andrew Farrell,Joey Flores,Timur R. Galeev,David U. Gorkin,David U. Gorkin,Madhusudan Gujral,Victor Guryev,William Haynes Heaton,Jonas Korlach,Sushant Kumar,Jee Young Kwon,Ernest T. Lam,Jong Eun Lee,Joyce V. Lee,Wan-Ping Lee,Sau Peng Lee,Shantao Li,Patrick Marks,Karine A. Viaud-Martinez,Sascha Meiers,Katherine M. Munson,Fabio C. P. Navarro,Bradley J. Nelson,Conor Nodzak,Amina Noor,Sofia Kyriazopoulou-Panagiotopoulou,Andy Wing Chun Pang,Yunjiang Qiu,Yunjiang Qiu,Gabriel Rosanio,Mallory Ryan,Adrian M. Stütz,Diana C.J. Spierings,Alistair Ward,Anne Marie E. Welch,Ming Xiao,Wei Xu,Chengsheng Zhang,Qihui Zhu,Xiangqun Zheng-Bradley,Ernesto Lowy,Sergei Yakneen,Steven A. McCarroll,Steven A. McCarroll,Goo Jun,Li Ding,Chong-Lek Koh,Bing Ren,Bing Ren,Paul Flicek,Ken Chen,Mark Gerstein,Pui-Yan Kwok,Peter M. Lansdorp,Peter M. Lansdorp,Peter M. Lansdorp,Gabor T. Marth,Jonathan Sebat,Xinghua Shi,Ali Bashir,Kai Ye,Scott E. Devine,Michael E. Talkowski,Michael E. Talkowski,Ryan E. Mills,Tobias Marschall,Jan O. Korbel,Evan E. Eichler,Charles Lee +107 more
TL;DR: A suite of long-read, short- read, strand-specific sequencing technologies, optical mapping, and variant discovery algorithms are applied to comprehensively analyze three trios to define the full spectrum of human genetic variation in a haplotype-resolved manner.
Journal ArticleDOI
Characterizing the Major Structural Variant Alleles of the Human Genome
Peter A. Audano,Arvis Sulovari,Tina A. Graves-Lindsay,Stuart Cantsilieris,Melanie Sorensen,AnneMarie E. Welch,Max L. Dougherty,Bradley J. Nelson,Ankeeta Shah,Susan K. Dutcher,Wesley C. Warren,Vincent Magrini,Vincent Magrini,Sean McGrath,Yang I. Li,Richard K. Wilson,Richard K. Wilson,Evan E. Eichler +17 more
TL;DR: A ninefold SV bias toward the last 5 Mbp of human chromosomes is reported with nearly 55% of all VNTRs (variable number of tandem repeats) mapping to this portion of the genome.
Journal ArticleDOI
High-resolution comparative analysis of great ape genomes
Zev N. Kronenberg,Ian T. Fiddes,David Gordon,Shwetha C. Murali,Stuart Cantsilieris,Olivia S. Meyerson,Jason G. Underwood,Jason G. Underwood,Bradley J. Nelson,Mark Chaisson,Mark Chaisson,Max L. Dougherty,Katherine M. Munson,Alex Hastie,Mark Diekhans,Fereydoun Hormozdiari,Nicola Lorusso,Kendra Hoekzema,Ruolan Qiu,Karen Clark,Archana Raja,Anne Marie E. Welch,Melanie Sorensen,Carl Baker,Robert S. Fulton,Joel Armstrong,Tina A. Graves-Lindsay,Ahmet M. Denli,Emma R. Hoppe,PingHsun Hsieh,Christopher M. Hill,Andy Wing Chun Pang,Joyce V. Lee,Ernest T. Lam,Susan K. Dutcher,Fred H. Gage,Wesley C. Warren,Jay Shendure,David Haussler,Valerie A. Schneider,Han Cao,Mario Ventura,Richard K. Wilson,Benedict Paten,Alex A. Pollen,Evan E. Eichler +45 more
TL;DR: The improved ape genome assemblies provide the most comprehensive view to date of intermediate-size structural variation and highlight several dozen genes associated withStructural variation and brain-expression differences between humans and chimpanzees.
Journal ArticleDOI
Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly
Tatsiana Aneichyk,Tatsiana Aneichyk,William T. Hendriks,Rachita Yadav,Rachita Yadav,David Shin,Dadi Gao,Dadi Gao,Christine A. Vaine,Ryan L. Collins,Ryan L. Collins,Aloysius Domingo,Benjamin Currall,Alexei Stortchevoi,Trisha Multhaupt-Buell,Ellen B. Penney,Lilian Cruz,Jyotsna Dhakal,Harrison Brand,Carrie Hanscom,Caroline Antolik,Marisela E. Dy,Ashok Ragavendran,Jason G. Underwood,Jason G. Underwood,Stuart Cantsilieris,Katherine M. Munson,Evan E. Eichler,Evan E. Eichler,Patrick Acuna,Criscely L. Go,R. Dominic G. Jamora,Raymond L. Rosales,Deanna M. Church,Stephen R. Williams,Sarah Garcia,Christine Klein,Ulrich Müller,Kirk C. Wilhelmsen,H. T. Marc Timmers,Yechiam Sapir,Brian J. Wainger,Daniel Henderson,Naoto Ito,Neil I. Weisenfeld,David M. Jaffe,Nutan Sharma,Xandra O. Breakefield,Laurie J. Ozelius,D. Cristopher Bragg,Michael E. Talkowski +50 more
TL;DR: The integrated genome and transcriptome assembly technologies suggest an SVA-mediated aberrant transcriptional mechanism associated with XDP and may provide a roadmap for layered technologies and integrated assembly-based analyses for other unsolved Mendelian disorders.
Journal ArticleDOI
The evolution and population diversity of human-specific segmental duplications
Megan Y. Dennis,Megan Y. Dennis,Lana Harshman,Bradley J. Nelson,Osnat Penn,Stuart Cantsilieris,John Huddleston,Francesca Antonacci,Kelsi Penewit,Laura Denman,Archana Raja,Carl Baker,Kenneth M. K. Mark,Maika Malig,Nicolette Janke,Claudia Yadira Espinoza,Holly A.F. Stessman,Xander Nuttle,Kendra Hoekzema,Tina A Lindsay-Graves,Richard K. Wilson,Evan E. Eichler +21 more
TL;DR: It is shown that HSDs are non-randomly organized, associate preferentially with ancestral ape duplications termed ‘core duplicons’ and evolved primarily in an interspersed inverted orientation, candidates for the evolution of human-specific adaptive traits.