Kristiina Rajamäki

TL;DR: The data suggest that acidic environment represents a novel endogenous danger signal alerting the innate immunity, and may contribute to inflammation in acidosis-associated pathologies such as atherosclerosis and post-ischemic inflammatory responses.

TL;DR: SAA can induce the expression of pro–IL-1β and activation of the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway and may promote the production of IL-1 β in tissues during systemic inflammation.

TL;DR: Findings provide insight into the interplay between epigenetic modulators and transcription factor activity in hematological neoplasia, but do not confirm the putative role of TET2 in atherosclerosis.

TL;DR: The p38&dgr; mitogen-activated protein kinase was identified as a novel regulator of NLRP3 inflammasome activation in primary human macrophages, and thus, represents a potential target for modulation of atherosclerotic inflammation.

TL;DR: In this article, the authors comprehensively characterize IBD-associated tumorigenesis integrating multiple high-throughput approaches, and compare the results with in-house data sets from sCRCs.