L
Laurent F. Hennequin
Researcher at Nestlé
Publications - 11
Citations - 131
Laurent F. Hennequin is an academic researcher from Nestlé. The author has contributed to research in topics: Squaramide & Dendritic cell. The author has an hindex of 6, co-authored 11 publications receiving 93 citations.
Papers
More filters
Journal ArticleDOI
A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils
Baptiste Janela,Amit Patel,Mai Chan Lau,Chi Ching Goh,Rasha Msallam,Wan Ting Kong,Michael G. Fehlings,Sandra Hubert,Josephine Lum,Yannick Simoni,Benoit Malleret,Benoit Malleret,Francesca Zolezzi,Francesca Zolezzi,Jinmiao Chen,Michael Poidinger,Ansuman T. Satpathy,Carlos G. Briseño,Christian Wohn,Bernard Malissen,Kenneth M. Murphy,Alexander A. Maini,Leen Vanhoutte,Martin Guilliams,Emmanuel Vial,Laurent F. Hennequin,Evan W. Newell,Lai Guan Ng,Philippe Musette,Simon Yona,Feriel Hacini-Rachinel,Florent Ginhoux +31 more
TL;DR: Skin cDC1s are essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation as well as in a model of bacterial insult in human skin.
Journal ArticleDOI
Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis.
Jean-Guy Boiteau,Gilles Ouvry,Jean-Marie Arlabosse,Stéphanie Astri,Audrey Beillard,Yushma Bhurruth-Alcor,Laetitia Bonnary,Claire Bouix-Peter,Karine Bouquet,Marilyne Bourotte,Isabelle Cardinaud,Catherine Comino,Benoit Deprez,Denis Duvert,Angélique Feret,Feriel Hacini-Rachinel,Craig S. Harris,Anne-Pascale Luzy,Arnaud Mathieu,Corinne Millois,Nicolas Orsini,Jonathan Pascau,Artur Pinto,David Piwnica,Gaëlle Polge,Arnaud Reitz,Kevin Reverse,Nicolas Rodeville,Patricia Rossio,Delphine Spiesse,Samuel Tabet,Nathalie Taquet,Loïc Tomas,Emmanuel Vial,Laurent F. Hennequin +34 more
TL;DR: The discovery of clinical candidate 26a is presented, showing robust in vivo activity in an oxazolone-mediated inflammation model and efficiently developed to yield the API in 47% overall yield.
Journal ArticleDOI
Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.
Jean-François Fournier,Yushma Bhurruth-Alcor,Branislav Musicki,Jerome Aubert,Michèle Aurelly,Claire Bouix-Peter,Karinne Bouquet,Laurent Chantalat,Marion Delorme,Bénédicte Drean,Gwenaëlle Duvert,Nicolas Fleury-Brégeot,Blanche Gauthier,Karine Grisendi,Craig S. Harris,Laurent F. Hennequin,T. Isabet,Florence Joly,Guillaume Lafitte,Corinne Millois,Rémy Morgentin,Jonathan Pascau,David Piwnica,Yves Rival,Catherine Soulet,Etienne Thoreau,Loïc Tomas +26 more
TL;DR: A series of squaramide-based hydroxamic acids were designed, synthesized and evaluated against human HDAC enzyme, and leads with improved solubility and metabolic profiles were shown to be class I, IIB and IV selective.
Journal ArticleDOI
Discovery and Characterization of CD12681, a Potent RORγ Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis.
Gilles Ouvry,Nicolas Atrux-Tallau,Franck Bihl,Aline Bondu,Claire Bouix-Peter,Isabelle Carlavan,Olivier Christin,Marie-Josée Cuadrado,Claire Defoin-Platel,Sophie Deret,Denis Duvert,Christophe Feret,Mathieu Forissier,Jean-François Fournier,David Froude,Feriel Hacini-Rachinel,Craig S. Harris,Catherine Hervouet,Hélène Huguet,Guillaume Lafitte,Anne-Pascale Luzy,Branislav Musicki,Danielle Orfila,Benjamin Ozello,Coralie Pascau,Jonathan Pascau,Veronique Parnet,Guillaume Peluchon,Romain Pierre,David Piwnica,Catherine Raffin,Patricia Rossio,Delphine Spiesse,Nathalie Taquet,Etienne Thoreau,Rodolphe Vatinel,Emmanuel Vial,Laurent F. Hennequin +37 more
TL;DR: The efforts to identify a potent RORγ inverse agonist compatible with topical application for the treatment of skin diseases culminated in the discovery of N‐(2,4‐dimethylphenyl)‐N‐isobutyl‐2‐oxo‐1‐[(tetrahydro‐2H‐pyran‐4‐yl)methyl]‐2,3‐dihydro •1H‐benzo‐5‐sulfonamide.
Journal ArticleDOI
Sulfoximines as potent RORγ inverse agonists.
Gilles Ouvry,Franck Bihl,Claire Bouix-Peter,Olivier Christin,Claire Defoin-Platel,Sophie Deret,Christophe Feret,David Froude,Feriel Hacini-Rachinel,Craig S. Harris,Catherine Hervouet,Guillaume Lafitte,Anne-Pascale Luzy,Branislav Musicki,Danielle Orfila,Veronique Parnet,Coralie Pascau,Jonathan Pascau,Romain Pierre,Catherine Raffin,Patricia Rossio,Delphine Spiesse,Nathalie Taquet,Etienne Thoreau,Rodolphe Vatinel,Emmanuel Vial,Laurent F. Hennequin +26 more
TL;DR: SAR of the replacement of the hydroxymethyl group found on known modulators is presented, leading to the identification of sulfoximine derivatives as potent modulators with pharmacological activity in the in vivo mouse Imiquimod psoriasis model.